(Q39044453)

8 September 2017

Restriction of the conformational dynamics of the cyclic acyldepsipeptide antibiotics improves their antibacterial activity (English)

1 reference

8 September 2017

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24422534%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

author name string

Daniel W Carney

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24422534%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Karl R Schmitz

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24422534%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Jonathan V Truong

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24422534%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Jason K Sello

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24422534%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

language of work or name

English

0 references

publication date

24 January 2014

1 reference

Journal of the American Chemical Society

8 September 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24422534%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

volume

136

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24422534%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24422534%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

page(s)

1922-1929

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24422534%20AND%20SRC:MED&resulttype=core&format=json

Activated ClpP kills persisters and eradicates a chronic biofilm infection

31 May 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

Proteases in Mycobacterium tuberculosis pathogenesis: potential as drug targets

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

Getting in shape: controlling peptide bioactivity and bioavailability using conformational constraints

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

Bacterial proteolytic complexes as therapeutic targets

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

ClpP: a structurally dynamic protease regulated by AAA+ proteins

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

Methyl effects on protein-ligand binding

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

Antibiotic acyldepsipeptides activate ClpP peptidase to degrade the cell division protein FtsZ

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

Acyl depsipeptide (ADEP) resistance in Streptomyces

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

The methylation effect in medicinal chemistry.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

AAA+ proteases: ATP-fueled machines of protein destruction

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

Acyldepsipeptide antibiotics induce the formation of a structured axial channel in ClpP: A model for the ClpX/ClpA-bound state of ClpP.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

ClpP: a distinctive family of cylindrical energy-dependent serine proteases

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

ATP-dependent proteases of bacteria: recognition logic and operating principles

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

Dysregulation of bacterial proteolytic machinery by a new class of antibiotics

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

The ClpP protease of Streptococcus pneumoniae modulates virulence gene expression and protects against fatal pneumococcal challenge

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

Effect of heat shock and mutations in ClpL and ClpP on virulence gene expression in Streptococcus pneumoniae

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

Global transcriptional analysis of clpP mutations of type 2 Streptococcus pneumoniae and their effects on physiology and virulence

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

Molecular properties that influence the oral bioavailability of drug candidates

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

Effects of protein stability and structure on substrate processing by the ClpXP unfolding and degradation machine

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

Unfolding and internalization of proteins by the ATP-dependent proteases ClpXP and ClpAP.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

Lowering the entropic barrier for binding conformationally flexible inhibitors to enzymes

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

The ClpXP and ClpAP proteases degrade proteins with carboxy-terminal peptide tails added by the SsrA-tagging system

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

The structure of ClpP at 2.3 A resolution suggests a model for ATP-dependent proteolysis

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

Endopeptidase Clp: ATP-dependent Clp protease from Escherichia coli

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

Validation of the essential ClpP protease in Mycobacterium tuberculosis as a novel drug target

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

Distinct static and dynamic interactions control ATPase-peptidase communication in a AAA+ protease

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

Global virulence regulation in Staphylococcus aureus: pinpointing the roles of ClpP and ClpX in the sar/agr regulatory network

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

Control of substrate gating and translocation into ClpP by channel residues and ClpX binding.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

Protein quality control: triage by chaperones and proteases

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

Antibacterial activity of and resistance to small molecule inhibitors of the ClpP peptidase

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

Enopeptin A, a novel depsipeptide antibiotic with anti-bacteriophage activity

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

Activators of cylindrical proteases as antimicrobials: identification and development of small molecule activators of ClpP protease

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

Diversity-oriented synthesis of cyclic acyldepsipeptides leads to the discovery of a potent antibacterial agent

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

Structurally refined beta-lactones as potent inhibitors of devastating bacterial virulence factors.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

Beta-lactones as specific inhibitors of ClpP attenuate the production of extracellular virulence factors of Staphylococcus aureus

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

Conformational flexibility, internal hydrogen bonding, and passive membrane permeability: successful in silico prediction of the relative permeabilities of cyclic peptides

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

Crystal structure at 1.9A of E. coli ClpP with a peptide covalently bound at the active site.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

Testing the conformational hypothesis of passive membrane permeability using synthetic cyclic peptide diastereomers.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

Rebuilt AAA + motors reveal operating principles for ATP-fuelled machines

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

Communication between ClpX and ClpP during substrate processing and degradation

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

Alternative roles of ClpX and ClpP in Staphylococcus aureus stress tolerance and virulence

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

Dynamics of substrate denaturation and translocation by the ClpXP degradation machine

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

The ClpP serine protease is essential for the intracellular parasitism and virulence of Listeria monocytogenes

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004210

Conformational constraint in protein ligand design and the inconsistency of binding entropy

21 August 2018

1 reference

12 December 2020

Medicinal chemistry optimization of acyldepsipeptides of the enopeptin class antibiotics.

1 reference

12 December 2020

Deuterium exchange as an indicator of hydrogen bond donors and acceptors

1 reference

12 December 2020

Crystal structure determination of Escherichia coli ClpP starting from an EM-derived mask

1 reference

12 December 2020

Effect of Conformational Flexibility and Solvation on Receptor-Ligand Binding Free Energies

1 reference

12 December 2020

Investigation of the configurational stabilities of chiral isocyanoacetates in multicomponent reactions

1 reference

12 December 2020

Ligand preorganization may be accompanied by entropic penalties in protein-ligand interactions

1 reference

12 December 2020

Identifiers

DOI

10.1021/JA410385C

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24422534%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24422534%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

PubMed publication ID

24422534

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24422534%20AND%20SRC:MED&resulttype=core&format=json