(Q34221202)

31 July 2017

Antibiotic acyldepsipeptides activate ClpP peptidase to degrade the cell division protein FtsZ (English)

1 reference

31 July 2017

0 references

Peter Sass

1

0 references

author name string

Michaele Josten

2

1 reference

31 July 2017

Kirsten Famulla

3

1 reference

31 July 2017

Guido Schiffer

4

1 reference

31 July 2017

Hans-Georg Sahl

5

1 reference

31 July 2017

Leendert Hamoen

6

1 reference

31 July 2017

Heike Brötz-Oesterhelt

7

1 reference

31 July 2017

language of work or name

English

0 references

publication date

3 October 2011

1 reference

Proceedings of the National Academy of Sciences of the United States of America

31 July 2017

1 reference

31 July 2017

108

1 reference

31 July 2017

42

1 reference

31 July 2017

17474-17479

1 reference

describes a project that uses

31 July 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3198362/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Acyldepsipeptide antibiotics induce the formation of a structured axial channel in ClpP: A model for the ClpX/ClpA-bound state of ClpP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198362

Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198362

The 10 x '20 Initiative: pursuing a global commitment to develop 10 new antibacterial drugs by 2020.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198362

The antibacterial cell division inhibitor PC190723 is an FtsZ polymer-stabilizing agent that induces filament assembly and condensation.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198362

Reduced vancomycin susceptibility in Staphylococcus aureus, including vancomycin-intermediate and heterogeneous vancomycin-intermediate strains: resistance mechanisms, laboratory detection, and clinical implications

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198362

The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198362

Adapting the machine: adaptor proteins for Hsp100/Clp and AAA+ proteases

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198362

ClpXP protease degrades the cytoskeletal protein, FtsZ, and modulates FtsZ polymer dynamics

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198362

Characterisation of a Staphylococcus aureus strain with progressive loss of susceptibility to vancomycin and daptomycin during therapy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198362

ClpX inhibits FtsZ assembly in a manner that does not require its ATP hydrolysis-dependent chaperone activity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198362

Emergence of extensively drug-resistant and pandrug-resistant Gram-negative bacilli in Europe

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198362

Dynamic control of the DNA replication initiation protein DnaA by Soj/ParA

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198362

An inhibitor of FtsZ with potent and selective anti-staphylococcal activity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198362

Pathogenesis of methicillin-resistant Staphylococcus aureus infection

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198362

Clp ATPases and ClpP proteolytic complexes regulate vital biological processes in low GC, Gram-positive bacteria

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198362

Lytic activity of recombinant bacteriophage phi11 and phi12 endolysins on whole cells and biofilms of Staphylococcus aureus.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198362

Dysregulation of bacterial proteolytic machinery by a new class of antibiotics

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198362

The ClpX chaperone modulates assembly of the tubulin-like protein FtsZ.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198362

Recruitment of penicillin-binding protein PBP2 to the division site of Staphylococcus aureus is dependent on its transpeptidation substrates

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198362

Tubulin and FtsZ form a distinct family of GTPases

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198362

Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198362

Changes in the epidemiology of methicillin-resistant Staphylococcus aureus in intensive care units in US hospitals, 1992-2003.

28 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1110385108

Linezolid resistance in a clinical isolate of Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1110385108

Postgenomic strategies in antibacterial drug discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1110385108

Molecular chaperones and protein quality control

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1110385108

Two-step assembly dynamics of the Bacillus subtilis divisome

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1110385108

Bacterial cell division: assembly, maintenance and disassembly of the Z ring

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1110385108

Crystal structure of the bacterial cell-division protein FtsZ

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1110385108

ClpP of Bacillus subtilis is required for competence development, motility, degradative enzyme synthesis, growth at high temperature and sporulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1110385108

The chromosome partitioning proteins Soj (ParA) and Spo0J (ParB) contribute to accurate chromosome partitioning, separation of replicated sister origins, and regulation of replication initiation in Bacillus subtilis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1110385108

Stress induction of the Bacillus subtilis clpP gene encoding a homologue of the proteolytic component of the Clp protease and the involvement of ClpP and ClpX in stress tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1110385108

Loss-of-function mutations in yjbD result in ClpX- and ClpP-independent competence development of Bacillus subtilis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1110385108

The interplay of ClpXP with the cell division machinery in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1110385108

Multiple effects of benzamide antibiotics on FtsZ function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1110385108

Identification and characterization of the first class of potent bacterial acetyl-CoA carboxylase inhibitors with antibacterial activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1110385108

Competence in Bacillus subtilis is controlled by regulated proteolysis of a transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1110385108

Two-week inhalation toxicity of polymeric diphenylmethane-4, 4'-diisocyanate (PMDI) in rats: analysis of biochemical and morphological markers of early pulmonary response

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21969594

12 December 2020

inferred from PubMed ID database lookup

The FtsZ protein of Bacillus subtilis is localized at the division site and has GTPase activity that is dependent upon FtsZ concentration

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21969594

12 December 2020

inferred from PubMed ID database lookup

Medicinal chemistry optimization of acyldepsipeptides of the enopeptin class antibiotics.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21969594

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1073/PNAS.1110385108

1 reference

31 July 2017

0 references

1 reference

31 July 2017

1 reference