(Q47811083)

5 February 2018

title

Identification and characterization of the first class of potent bacterial acetyl-CoA carboxylase inhibitors with antibacterial activity (English)

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5 February 2018

author name string

Christoph Freiberg

1

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5 February 2018

Nina A Brunner

2

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5 February 2018

Guido Schiffer

3

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5 February 2018

Thomas Lampe

4

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5 February 2018

Jens Pohlmann

5

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5 February 2018

Michael Brands

6

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5 February 2018

Martin Raabe

7

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5 February 2018

Dieter Häbich

8

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5 February 2018

Karl Ziegelbauer

9

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5 February 2018

language of work or name

English

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publication date

2 April 2004

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5 February 2018

Journal of Biological Chemistry

number of pages

8

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based on heuristic

inferred from page(s)

published in

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5 February 2018

volume

279

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5 February 2018

issue

25

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5 February 2018

page(s)

26066-26073

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5 February 2018

Animal fatty acid synthase: functional mapping and cloning and expression of the domain I constituent activities

cites work

1 reference

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Escherichia coli as a model for the regulation of dissociable (type II) fatty acid biosynthesis

21 January 2018

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Bacterial fatty acid biosynthesis: targets for antibacterial drug discovery

21 January 2018

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Lipid biosynthesis as a target for antibacterial agents

21 January 2018

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Bacterial fatty-acid biosynthesis: a genomics-driven target for antibacterial drug discovery

21 January 2018

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Triclosan targets lipid synthesis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M402989200

Broad spectrum antimicrobial biocides target the FabI component of fatty acid synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402989200

Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M402989200

Response of Bacillus subtilis to cerulenin and acquisition of resistance

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M402989200

Identification, substrate specificity, and inhibition of the Streptococcus pneumoniae beta-ketoacyl-acyl carrier protein synthase III (FabH).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402989200

First X-ray cocrystal structure of a bacterial FabH condensing enzyme and a small molecule inhibitor achieved using rational design and homology modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402989200

Purification, characterization, and identification of novel inhibitors of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M402989200

Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI)

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M402989200

Discovery of a novel and potent class of FabI-directed antibacterial agents

21 January 2018

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Indole Naphthyridinones as Inhibitors of Bacterial Enoyl-ACP Reductases FabI and FabK

21 January 2018

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Inhibition of Escherichia coli acetyl coenzyme A carboxylase by acyl-acyl carrier protein

21 January 2018

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FapR, a Bacterial Transcription Factor Involved in Global Regulation of Membrane Lipid Biosynthesis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M402989200

Multi-subunit acetyl-CoA carboxylases

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M402989200

Stabilization of an acetyl-coenzyme a carboxylase complex from Pseudomonas citronellolis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402989200

A bisubstrate analog inhibitor of the carboxyltransferase component of acetyl-CoA carboxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402989200

The subcellular localization of acetyl-CoA carboxylase 2

21 January 2018

1 reference

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Insertion of inverted Ter sites into the terminus region of the Escherichia coli chromosome delays completion of DNA replication and disrupts the cell cycle.

21 January 2018

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Overexpression and kinetic characterization of the carboxyltransferase component of acetyl-CoA carboxylase.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M402989200

Regulation of fatty acid elongation and initiation by acyl-acyl carrier protein in Escherichia coli.

21 January 2018

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M402989200

Carboxyltransferase component of acetyl-CoA carboxylase from Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402989200

YkrB is the main peptide deformylase in Bacillus subtilis, a eubacterium containing two functional peptide deformylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402989200

Erratum: A triclosan-resistant bacterial enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402989200

21 January 2018

Identifiers

DOI

10.1074/JBC.M402989200

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5 February 2018

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5 February 2018