(Q34444163)

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Diapocynin, a dimer of the NADPH oxidase inhibitor apocynin, reduces ROS production and prevents force loss in eccentrically contracting dystrophic muscle

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25329652%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

Diapocynin, a dimer of the NADPH oxidase inhibitor apocynin, reduces ROS production and prevents force loss in eccentrically contracting dystrophic muscle (English)

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25329652%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

Hesham M Ismail

1

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21 February 2020

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21 February 2020

Leonardo Scapozza

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Leonardo Scapozza

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21 February 2020

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Olivier M Dorchies

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21 February 2020

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17 October 2014

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21 February 2020

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21 February 2020

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21 February 2020

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21 February 2020

e110708

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21 February 2020

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17 October 2014

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0 references

Inhibition of iPLA2 β and of stretch-activated channels by doxorubicin alters dystrophic muscle function.

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A model of interaction between nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and apocynin analogues by docking method

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X-ROS signaling in the heart and skeletal muscle: stretch-dependent local ROS regulates [Ca²⁺]i

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Contribution of oxidative stress to pathology in diaphragm and limb muscles with Duchenne muscular dystrophy

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Anti-inflammatory and neuroprotective effects of an orally active apocynin derivative in pre-clinical models of Parkinson's disease

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Studies of mitochondrial and nonmitochondrial sources implicate nicotinamide adenine dinucleotide phosphate oxidase(s) in the increased skeletal muscle superoxide generation that occurs during contractile activity

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Microtubules underlie dysfunction in duchenne muscular dystrophy.

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The NADPH oxidase family and its inhibitors.

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Pre-clinical drug tests in the mdx mouse as a model of dystrophinopathies: an overview

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Quantitative evaluation of the beneficial effects in the mdx mouse of epigallocatechin gallate, an antioxidant polyphenol from green tea.

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Reactive oxygen species in skeletal muscle signaling.

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6 July 2018

Bromoenol lactone inhibits voltage-gated Ca2+ and transient receptor potential canonical channels

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NADPH oxidase inhibitors: a patent review

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6 July 2018

Skeletal muscle NADPH oxidase is increased and triggers stretch-induced damage in the mdx mouse

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6 July 2018

Increased catalase expression improves muscle function in mdx mice

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6 July 2018

Comparative pharmacology of chemically distinct NADPH oxidase inhibitors

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6 July 2018

Phospholipase A2-derived lysophosphatidylcholine triggers Ca2+ entry in dystrophic skeletal muscle fibers.

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6 July 2018

Reciprocal amplification of ROS and Ca(2+) signals in stressed mdx dystrophic skeletal muscle fibers.

1 reference

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6 July 2018

Apocynin: molecular aptitudes

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6 July 2018

Dystrophin-deficient cardiomyopathy in mouse: expression of Nox4 and Lox are associated with fibrosis and altered functional parameters in the heart

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6 July 2018

Dose formulation and analysis of diapocynin

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6 July 2018

Bioavailability of apocynin through its conversion to glycoconjugate but not to diapocynin

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6 July 2018

The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology

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The role of free radicals in the pathophysiology of muscular dystrophy

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Diphenyleneiodonium inhibits the cell redox metabolism and induces oxidative stress

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6 July 2018

Role of superoxide as a signaling molecule.

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Molecular pathophysiology and targeted therapeutics for muscular dystrophy

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6 July 2018

Invited Review: redox modulation of skeletal muscle contraction: what we know and what we don't

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Dystrophin protects the sarcolemma from stresses developed during muscle contraction

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6 July 2018

Complete cloning of the duchenne muscular dystrophy (DMD) cDNA and preliminary genomic organization of the DMD gene in normal and affected individuals

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N-Acetylcysteine ameliorates skeletal muscle pathophysiology in mdx mice

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21 January 2018

Green tea extract and its major polyphenol (-)-epigallocatechin gallate improve muscle function in a mouse model for Duchenne muscular dystrophy.

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21 January 2018

Skeletal muscle sarcoplasmic reticulum contains a NADH-dependent oxidase that generates superoxide.

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Apocynin inhibits NADPH oxidase in phagocytes but stimulates ROS production in non-phagocytic cells

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21 January 2018

Diapocynin versus apocynin as pretranscriptional inhibitors of NADPH oxidase and cytokine production by peripheral blood mononuclear cells

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21 January 2018

Streptomycin reduces stretch-induced membrane permeability in muscles from mdx mice.

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Inhibition of NADPH oxidase activation in endothelial cells by ortho-methoxy-substituted catechols

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Pro-oxidant activity of apocynin radical.

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Involvement of calcium-independent phospholipase A2 in hydrogen peroxide-induced accumulation of free fatty acids in human U937 cells

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Effects of stretch-activated channel blockers on [Ca2+]i and muscle damage in the mdx mouse.

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Antioxidant activity and phenolic compounds in selected herbs

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Direct scavenging of nitric oxide and superoxide by green tea.

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Metabolic activation of natural phenols into selective oxidative burst agonists by activated human neutrophils

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12 December 2020

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The reactivity of ortho-methoxy-substituted catechol radicals with sulfhydryl groups: contribution for the comprehension of the mechanism of inhibition of NADPH oxidase by apocynin

1 reference

https://pubmed.ncbi.nlm.nih.gov/25329652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phospholipase A2 activity in dystrophinopathies

1 reference

https://pubmed.ncbi.nlm.nih.gov/25329652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional role of store-operated and stretch-activated channels in murine adult skeletal muscle fibres

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ca2+-independent phospholipase A2 enhances store-operated Ca2+ entry in dystrophic skeletal muscle fibers

1 reference

https://pubmed.ncbi.nlm.nih.gov/25329652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Green tea extract decreases muscle necrosis in mdx mice and protects against reactive oxygen species

1 reference

https://pubmed.ncbi.nlm.nih.gov/25329652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Scavenging mechanisms of (-)-epigallocatechin gallate and (-)-epicatechin gallate on peroxyl radicals and formation of superoxide during the inhibitory action

1 reference

https://pubmed.ncbi.nlm.nih.gov/25329652

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based on heuristic

inferred from PubMed ID database lookup

Melatonin improves muscle function of the dystrophic mdx5Cv mouse, a model for Duchenne muscular dystrophy

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1371/JOURNAL.PONE.0110708

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25329652%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

2014PLoSO...9k0708I

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25329652%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25329652%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

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