(Q34448353)

English

Ecto-nucleotidase activities of promastigotes from Leishmania (Viannia) braziliensis relates to parasite infectivity and disease clinical outcome

scientific article

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Ecto-nucleotidase activities of promastigotes from Leishmania (Viannia) braziliensis relates to parasite infectivity and disease clinical outcome (English)

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

1 reference

based on heuristic

inferred from title

Tiago D Serafim

object named as

Tiago D Serafim

4

0 references

author name string

Pauline M Leite

1

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Rodrigo S Gomes

2

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Amanda B Figueiredo

3

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Wagner L Tafuri

5

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Carolina C de Souza

6

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Sandra A L Moura

7

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Juliana L R Fietto

8

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Maria N Melo

9

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Fátima Ribeiro-Dias

10

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Milton A P Oliveira

11

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Ana Rabello

12

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Luís C C Afonso

13

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

language of work or name

0 references

publication date

11 October 2012

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

PLoS Neglected Tropical Diseases

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

10

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

e1850

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

copyright license

Creative Commons Attribution 4.0 International

11 October 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

Adenosine and immune imbalance in visceral leishmaniasis: the possible role of ectonucleotidases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

6 July 2018

Reappraisal of the immunopathogenesis of disseminated leishmaniasis: in situ and systemic immune response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

6 July 2018

Leishmania-macrophage interactions: insights into the redox biology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

6 July 2018

Leishmania RNA virus controls the severity of mucocutaneous leishmaniasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

6 July 2018

Insulin-like growth factor-I induced and constitutive arginase activity differs among isolates of Leishmania derived from patients with diverse clinical forms of Leishmania braziliensis infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

6 July 2018

The -2518bp promoter polymorphism at CCL2/MCP1 influences susceptibility to mucosal but not localized cutaneous leishmaniasis in Brazil

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

6 July 2018

Adenosine: an immune modulator of inflammatory bowel diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

6 July 2018

A(2B) adenosine receptors in immunity and inflammation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

6 July 2018

Influence of Ecto-nucleoside triphosphate diphosphohydrolase activity on Trypanosoma cruzi infectivity and virulence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

6 July 2018

Functional dichotomy of dendritic cells following interaction with Leishmania braziliensis: infected cells produce high levels of TNF-alpha, whereas bystander dendritic cells are activated to promote T cell responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

6 July 2018

Demonstration and partial characterization of ecto-ATPase in Balamuthia mandrillaris and its possible role in the host-cell interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

6 July 2018

Effects of CXCL10 on dendritic cell and CD4+ T-cell functions during Leishmania amazonensis infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

6 July 2018

Purine and pyrimidine receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

6 July 2018

Resistance of Leishmania (Leishmania) amazonensis and Leishmania (Viannia) braziliensis to nitric oxide correlates with disease severity in Tegumentary Leishmaniasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

6 July 2018

Leishmania pifanoi amastigotes avoid macrophage production of superoxide by inducing heme degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

6 July 2018

Decreased in situ expression of interleukin-10 receptor is correlated with the exacerbated inflammatory and cytotoxic responses observed in mucosal leishmaniasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

6 July 2018

A zymographic study of metalloprotease activities in extracts and extracellular secretions of Leishmania (Viannia) braziliensis strains.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

6 July 2018

Heterogeneity in extracellular nucleotide hydrolysis among clinical isolates of Trichomonas vaginalis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

6 July 2018

Distinct Leishmania braziliensis isolates induce different paces of chemokine expression patterns.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

6 July 2018

Ecto-ATPases of clinical and non-clinical isolates of Acanthamoeba

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

6 July 2018

Alerting and tuning the immune response by extracellular nucleotides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

6 July 2018

Up-regulation of Th1-type responses in mucosal leishmaniasis patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

6 July 2018

Ecto-ATPases in protozoa parasites: looking for a function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

6 July 2018

The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

6 July 2018

Role of peroxynitrite in macrophage microbicidal mechanisms in vivo revealed by protein nitration and hydroxylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

6 July 2018

Site-directed mutagenesis of human nucleoside triphosphate diphosphohydrolase 3: the importance of residues in the apyrase conserved regions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

6 July 2018

Extracellular ATP induces a distorted maturation of dendritic cells and inhibits their capacity to initiate Th1 responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

6 July 2018

The role of nitric oxide in innate immunity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

6 July 2018

Ectonucleotide diphosphohydrolase activities in Entamoeba histolytica

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

6 July 2018

An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

6 July 2018

Leishmania, macrophages and complement: a tale of subversion and exploitation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

6 July 2018

Regulation of the expression of nitric oxide synthase and leishmanicidal activity by glycoconjugates of Leishmania lipophosphoglycan in murine macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

6 July 2018

Immune responses associated with susceptibility of C57BL/10 mice to Leishmania amazonensis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

6 July 2018

Nitrate biosynthesis in man

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

6 July 2018

A limiting dilution assay for quantifying Leishmania major in tissues of infected mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

6 July 2018

Immunopathology of American cutaneous leishmaniasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

6 July 2018

Leishmania amazonensis: characterization of an ecto-3'-nucleotidase activity and its possible role in virulence.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

27 October 2018

Immune and inflammatory responses to Leishmania amazonensis isolated from different clinical forms of human leishmaniasis in CBA mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

27 October 2018

Extracellular nucleotide metabolism in Leishmania: influence of adenosine in the establishment of infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

27 October 2018

Giardia lamblia: biochemical characterization of an ecto-ATPase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

27 October 2018

The 'danger' sensors that STOP the immune response: the A2 adenosine receptors?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

27 October 2018

Immune response induced by New World Leishmania species in C57BL/6 mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

27 October 2018

An alternative immunohistochemical method for detecting Leishmania amastigotes in paraffin-embedded canine tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

27 October 2018

Antigen specific correlations of cellular immune responses in human leishmaniasis suggests mechanisms for immunoregulation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

27 October 2018

A Mg-dependent ecto-ATPase is increased in the infective stages of Trypanosoma cruzi

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

27 October 2018

Characterization and immunolocalization of an NTP diphosphohydrolase of Trypanosoma cruzi

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

27 October 2018

Ecto-ATPase activity on the surface of Trypanosoma cruzi and its possible role in the parasite?host cell interaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

27 October 2018

Adenosine slows migration of dendritic cells but does not affect other aspects of dendritic cell maturation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

27 October 2018

Adenosine affects expression of membrane molecules, cytokine and chemokine release, and the T-cell stimulatory capacity of human dendritic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

27 October 2018

Characterization of an ecto-ATPase of Tritrichomonas foetus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

27 October 2018

A Mg-dependent ecto-ATPase in Leishmania amazonensis and its possible role in adenosine acquisition and virulence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

27 October 2018

A natural model of Leishmania major infection reveals a prolonged "silent" phase of parasite amplification in the skin before the onset of lesion formation and immunity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

27 October 2018

Effects of 4,4'-diisothyocyanatostilbene-2,2'-disulfonic acid on Trypanosoma cruzi proliferation and Ca(2+) homeostasis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

27 October 2018

Site-directed mutagenesis of a human brain ecto-apyrase: evidence that the E-type ATPases are related to the actin/heat shock 70/sugar kinase superfamily.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469556

27 October 2018

A microcolorimetric method for the determination of inorganic phosphorus

1 reference

https://pubmed.ncbi.nlm.nih.gov/23071853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dendritic cells as host cells for the promastigote and amastigote stages of Leishmania amazonensis: the role of opsonins in parasite uptake and dendritic cell maturation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23071853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leishmania chagasi: An ecto-3′-nucleotidase activity modulated by inorganic phosphate and its possible involvement in parasite–macrophage interaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/23071853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumour necrosis factor (TNF alpha) in leishmaniasis. I. TNF alpha mediates host protection against cutaneous leishmaniasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23071853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Basis for substrate specificity of the Toxoplasma gondii nucleoside triphosphate hydrolase

1 reference

https://pubmed.ncbi.nlm.nih.gov/23071853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trypanosoma brucei brucei: biochemical characterization of ecto-nucleoside triphosphate diphosphohydrolase activities

1 reference

https://pubmed.ncbi.nlm.nih.gov/23071853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/23071853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of protein-modifying reagents on ecto-apyrase from rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/23071853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leishmania amazonensisimpairs DC function by inhibiting CD40 expression via A2Badenosine receptor activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23071853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purine metabolism in Leishmania donovani and Leishmania braziliensis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23071853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human mucosal leishmaniasis: Neutrophils infiltrate areas of tissue damage that express high levels of Th17-related cytokines

1 reference

https://pubmed.ncbi.nlm.nih.gov/23071853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MMP-9 activity is induced by Leishmania braziliensis infection and correlates with mucosal leishmaniasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23071853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human cutaneous lieshmania in a mouse macrophage line: propagation and isolation of intracellular parasites

1 reference

https://pubmed.ncbi.nlm.nih.gov/23071853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Local immunological factors associated with recurrence of mucosal leishmaniasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23071853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leishmania amazonensis: Biological and biochemical characterization of ecto-nucleoside triphosphate diphosphohydrolase activities

1 reference

https://pubmed.ncbi.nlm.nih.gov/23071853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The influence of ecto-nucleotidases on Leishmania amazonensis infection and immune response in C57B/6 mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23071853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leishmania braziliensis isolates differing at the genome level display distinctive features in BALB/c mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23071853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site-directed mutagenesis of human endothelial cell ecto-ADPase/soluble CD39: requirement of glutamate 174 and serine 218 for enzyme activity and inhibition of platelet recruitment

1 reference

https://pubmed.ncbi.nlm.nih.gov/23071853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A study of the differential respiratory burst activity elicited by promastigotes and amastigotes of Leishmania donovani in murine resident peritoneal macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/23071853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Production of nitric oxide and superoxide by activated macrophages and killing of Leishmania major

1 reference

https://pubmed.ncbi.nlm.nih.gov/23071853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PNTD.0001850

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q34448353&oldid=2033550184"