(Q34448684)

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Interleukin-1β produced in response to islet autoantigen presentation differentiates T-helper 17 cells at the expense of regulatory T-cells: Implications for the timing of tolerizing immunotherapy

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Europe PubMed Central

PubMed publication ID

2 August 2017

Interleukin-1β produced in response to islet autoantigen presentation differentiates T-helper 17 cells at the expense of regulatory T-cells: Implications for the timing of tolerizing immunotherapy (English)

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Europe PubMed Central

PubMed publication ID

2 August 2017

1 reference

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Brendan O'Sullivan

object named as

Brendan O'Sullivan

3

0 references

object named as

Sanjoy Paul

6

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Raymond J Steptoe

object named as

Raymond Steptoe

10

0 references

object named as

Ranjeny Thomas

11

0 references

author name string

Sebastien Bertin-Maghit

1

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Dimeng Pang

2

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Shannon Best

4

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Emily Duggan

5

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Helen Thomas

7

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Thomas W H Kay

8

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Europe PubMed Central

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2 August 2017

Leonard C Harrison

9

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Europe PubMed Central

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2 August 2017

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27 October 2010

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Europe PubMed Central

PubMed publication ID

2 August 2017

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

60

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Europe PubMed Central

PubMed publication ID

2 August 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

248-257

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

copyright license

Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

27 August 2021

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April 2022 Public Data File from Crossref

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0 references

Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012178

6 July 2018

How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012178

6 July 2018

IL-17/Th17 promotes type 1 T cell immunity against pulmonary intracellular bacterial infection through modulating dendritic cell function

1 reference

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6 July 2018

The anti-interleukin-1 in type 1 diabetes action trial--background and rationale

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012178

6 July 2018

Critical regulation of early Th17 cell differentiation by interleukin-1 signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012178

6 July 2018

Inhibition of Th17 cells regulates autoimmune diabetes in NOD mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012178

6 July 2018

DC activated via dectin-1 convert Treg into IL-17 producers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012178

6 July 2018

A new role for an old player: do B cells unleash the self-reactive CD8+ T cell storm necessary for the development of type 1 diabetes?

1 reference

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6 July 2018

Molecular antagonism and plasticity of regulatory and inflammatory T cell programs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012178

6 July 2018

Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012178

6 July 2018

Innocuous IFNgamma induced by adjuvant-free antigen restores normoglycemia in NOD mice through inhibition of IL-17 production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012178

6 July 2018

Increased toll-like receptor (TLR) 2 and TLR4 expression in monocytes from patients with type 1 diabetes: further evidence of a proinflammatory state

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012178

6 July 2018

High glucose induces IL-1beta expression in human monocytes: mechanistic insights

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012178

6 July 2018

Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012178

6 July 2018

Increased monocytic activity and biomarkers of inflammation in patients with type 1 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012178

6 July 2018

Immunomodulatory dendritic cells require autologous serum to circumvent nonspecific immunosuppressive activity in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012178

6 July 2018

A comprehensive review of interventions in the NOD mouse and implications for translation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012178

6 July 2018

Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012178

6 July 2018

TRAF6 Is a Critical Factor for Dendritic Cell Maturation and Development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012178

6 July 2018

Prevention of diabetes in NOD mice by administration of dendritic cells deficient in nuclear transcription factor-kappaB activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012178

6 July 2018

Activation of dendritic cells through the interleukin 1 receptor 1 is critical for the induction of autoimmune myocarditis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012178

6 July 2018

Genes and cellular requirements for autoimmune diabetes susceptibility in nonobese diabetic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012178

6 July 2018

IL-4 expression at the onset of islet inflammation predicts nondestructive insulitis in nonobese diabetic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012178

6 July 2018

Multiple low-dose streptozotocin-induced hyperglycemia and insulitis in C57BL mice: Influence of inbred background, sex, and thymus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012178

6 July 2018

Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012178

6 July 2018

Antigen-specific suppression of inflammatory arthritis using liposomes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012178

27 October 2018

IL-1beta and IL-2 convert human Treg into T(H)17 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012178

27 October 2018

Association of IL-1ra and adiponectin with C-peptide and remission in patients with type 1 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012178

27 October 2018

Abnormal NF-kappa B function characterizes human type 1 diabetes dendritic cells and monocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012178

27 October 2018

Identification of a molecular signature in human type 1 diabetes mellitus using serum and functional genomics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012178

27 October 2018

Functional waning of naturally occurring CD4+ regulatory T-cells contributes to the onset of autoimmune diabetes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012178

27 October 2018

Dosing and timing effects of anti-CD40L therapy: predictions from a mathematical model of type 1 diabetes.

1 reference

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27 October 2018

Fetal calf serum-primed dendritic cells induce a strong anti-fetal calf serum immune response and diabetes protection in the non-obese diabetic mouse.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012178

27 October 2018

TLR4 mediates vaccine-induced protective cellular immunity to Bordetella pertussis: role of IL-17-producing T cells.

1 reference

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27 October 2018

IL-1 beta breaks tolerance through expansion of CD25+ effector T cells.

1 reference

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27 October 2018

Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial--Type 1.

1 reference

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27 October 2018

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27 October 2018

Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012178

27 October 2018

The expression of cytokine genes in the peritoneal macrophages and splenic CD4- and CD8-positive lymphocytes of the nonobese diabetic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012178

27 October 2018

Persistence of recipient lymphocytes in NOD mice after irradiation and bone marrow transplantation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012178

27 October 2018

Systemic overexpression of IL-10 induces CD4+CD25+ cell populations in vivo and ameliorates type 1 diabetes in nonobese diabetic mice in a dose-dependent fashion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012178

27 October 2018

Elevated NF-kappaB activation in nonobese diabetic mouse dendritic cells results in enhanced APC function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012178

27 October 2018

IL-1 receptor deficiency slows progression to diabetes in the NOD mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012178

27 October 2018

Gene Expression in Peripheral Blood Mononuclear Cells from Children with Diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012178

9 December 2018

Differentiated dendritic cells expressing nuclear RelB are predominantly located in rheumatoid synovial tissue perivascular mononuclear cell aggregates

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980463

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dendritic cells from nonobese diabetic mice exhibit a defect in NF-kappa B regulation due to a hyperactive I kappa B kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980463

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD40 ligation conditions dendritic cell antigen-presenting function through sustained activation of NF-kappaB

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980463

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antigen-specific suppression of a primed immune response by dendritic cells mediated by regulatory T cells secreting interleukin-10

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980463

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dendritic Cells Transduced to Express Interleukin-4 Prevent Diabetes in Nonobese Diabetic Mice with Advanced Insulitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980463

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980463

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Islet cytotoxicity of interleukin 1. Influence of culture conditions and islet donor characteristics

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980463

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention of diabetes in non-obese diabetic I-Ak transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980463

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical characterization of monocytes-macrophages and dendritic cells involved in the initiation of the insulitis and beta-cell destruction in NOD mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980463

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new method for isolation of murine islets with markedly improved yields

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980463

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980463

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin 1 beta, tumour necrosis factor-alpha and interleukin 1 receptor antagonist in newly diagnosed insulin-dependent diabetes mellitus: comparison to long-standing diabetes and healthy individuals

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980463

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980463

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD40 ligand-CD40 interactions are necessary for the initiation of insulitis and diabetes in nonobese diabetic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980463

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dendritic cells and macrophages are the first and major producers of TNF-alpha in pancreatic islets in the nonobese diabetic mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980463

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systemic delivery of interleukin 10 by intramuscular injection of expression plasmid DNA prevents autoimmune diabetes in nonobese diabetic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980463

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autoimmune diabetes is suppressed by transfer of proinsulin-encoding Gr-1+ myeloid progenitor cells that differentiate in vivo into resting dendritic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980463

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980463

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immune modulation and tolerance induction by RelB-silenced dendritic cells through RNA interference

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980463

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antigen-specific suppression of established arthritis in mice by dendritic cells deficient in NF-kappaB

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980463

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2337/DB10-0104

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Internet Archive ID

pubmed-PMC3012178

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

ResearchGate publication ID

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