(Q34448766)

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Both polymorphic variable number of tandem repeats and autoimmune regulator modulate differential expression of insulin in human thymic epithelial cells.

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14 February 2020

Both polymorphic variable number of tandem repeats and autoimmune regulator modulate differential expression of insulin in human thymic epithelial cells (English)

1 reference

Europe PubMed Central

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14 February 2020

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Matthieu Giraud

4

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14 February 2020

author name string

Chuan Qi Cai

1

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14 February 2020

Tao Zhang

2

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14 February 2020

Mary B Breslin

3

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14 February 2020

Michael S Lan

5

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14 February 2020

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28 September 2010

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14 February 2020

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14 February 2020

60

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14 February 2020

1

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14 February 2020

336-344

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14 February 2020

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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

27 August 2021

1 reference

April 2022 Public Data File from Crossref

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0 references

DAXX is a new AIRE-interacting protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012191

6 July 2018

Aire's partners in the molecular control of immunological tolerance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012191

6 July 2018

Thymus-specific deletion of insulin induces autoimmune diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012191

6 July 2018

Direct experimental evidence for quadruplex-quadruplex interaction within the human ILPR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012191

6 July 2018

Transcriptional regulation by AIRE: molecular mechanisms of central tolerance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012191

6 July 2018

The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012191

6 July 2018

Insulin as an autoantigen in NOD/human diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012191

6 July 2018

AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012191

6 July 2018

An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012191

6 July 2018

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012191

6 July 2018

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012191

6 July 2018

Variants in the human insulin gene that affect pre-mRNA splicing: is -23HphI a functional single nucleotide polymorphism at IDDM2?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012191

6 July 2018

The insulin gene in type 1 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012191

6 July 2018

Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012191

6 July 2018

Projection of an immunological self shadow within the thymus by the aire protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012191

6 July 2018

The autoimmune regulator (AIRE) is a DNA-binding protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012191

6 July 2018

The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012191

6 July 2018

An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012191

6 July 2018

Positional cloning of the APECED gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012191

6 July 2018

The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012191

6 July 2018

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012191

6 July 2018

The search for IDDM susceptibility genes: the next generation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012191

6 July 2018

Regulation of insulin gene expression by the IDDM associated, insulin locus haplotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012191

6 July 2018

Genetic analysis of type 1 diabetes using whole genome approaches

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012191

6 July 2018

Establishment and characterization of cloned human thymic epithelial cell lines. Analysis of adhesion molecule expression and cytokine production.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012191

6 July 2018

Clinical variation of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) in a series of 68 patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012191

6 July 2018

Highly variable expression of tissue-restricted self-antigens in human thymus: implications for self-tolerance and autoimmunity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012191

27 October 2018

Remapping the insulin gene/IDDM2 locus in type 1 diabetes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012191

27 October 2018

IDDM2-VNTR-encoded susceptibility to type 1 diabetes: dominant protection and parental transmission of alleles of the insulin gene-linked minisatellite locus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012191

27 October 2018

Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012191

27 October 2018

The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012191

27 October 2018

The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequences.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012191

27 October 2018

Analysis of a 1963-bp polymorphic region flanking the human insulin gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012191

27 October 2018

The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012191

9 December 2018

Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012191

9 December 2018

Insulin alleles and autoimmune regulator (AIRE) gene expression both influence insulin expression in the thymus

1 reference

https://pubmed.ncbi.nlm.nih.gov/20876716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and characterization of proinsulin-producing medullary thymic epithelial cell clones

1 reference

https://pubmed.ncbi.nlm.nih.gov/20876716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Questioning INS VNTR role in obesity and diabetes: subclasses tag IGF2-INS-TH haplotypes; and -23HphI as a STEP (splicing and translational efficiency polymorphism)

1 reference

https://pubmed.ncbi.nlm.nih.gov/20876716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of polymorphic splicing in the mechanism of the association of the insulin gene with diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20876716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Risk of autoimmune diabetes in APECED: association with short alleles of the 5′insulin VNTR

1 reference

https://pubmed.ncbi.nlm.nih.gov/20876716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Polymorphic Locus Near the Human Insulin Gene Is Associated with Insulin-dependent Diabetes Melliitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/20876716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autoimmune polyendocrinopathy--candidosis--ectodermal dystrophy (APECED): autosomal recessive inheritance

1 reference

https://pubmed.ncbi.nlm.nih.gov/20876716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2337/DB10-0255

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20876716%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

Internet Archive ID

pubmed-PMC3012191

0 references

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20876716%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20876716%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

ResearchGate publication ID

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