(Q34449752)

English

Protocatechuic acid inhibits cancer cell metastasis involving the down‐regulation of Ras/Akt/NF‐κB pathway and MMP‐2 production by targeting RhoB activation

scientific article published on January 1, 2011

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scholarly article

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Europe PubMed Central

PubMed publication ID

2 August 2017

Protocatechuic acid inhibits cancer cell metastasis involving the down-regulation of Ras/Akt/NF-κB pathway and MMP-2 production by targeting RhoB activation (English)

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Protocatechuic acid inhibits cancer cell metastasis involving the down‐regulation of Ras/Akt/NF‐κB pathway and MMP‐2 production by targeting RhoB activation (English)

1 reference

10.1111/J.1476-5381.2010.01022.X

https://api.crossref.org/works/10.1111/J.1476-5381.2010.01022.X

13 July 2024

0 references

3,4-dihydroxybenzoic acid

1 reference

ChEBI release 2020-05-28

author name string

Hui-Hsuan Lin

1

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Jing-Hsien Chen

2

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Fen-Pi Chou

3

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Chau-Jong Wang

4

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

language of work or name

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publication date

1 January 2011

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Europe PubMed Central

PubMed publication ID

2 August 2017

full work available at URL

https://europepmc.org/articles/pmc3012419?pdf=render

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20840540

13 July 2024

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20840540/pdf/?tool=EBI

Portable Document Format

online access status

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1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20840540

13 July 2024

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20840540/?tool=EBI

online access status

content deliverer

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20840540

13 July 2024

https://europepmc.org/articles/PMC3012419

online access status

content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20840540

13 July 2024

https://europepmc.org/articles/PMC3012419?pdf=render

Portable Document Format

online access status

content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20840540

13 July 2024

https://doi.org/10.1111/j.1476-5381.2010.01022.x

online access status

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20840540

13 July 2024

https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1476-5381.2010.01022.x

1 reference

10.1111/J.1476-5381.2010.01022.X

https://api.crossref.org/works/10.1111/J.1476-5381.2010.01022.X

13 July 2024

https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1476-5381.2010.01022.x

1 reference

10.1111/J.1476-5381.2010.01022.X

https://api.crossref.org/works/10.1111/J.1476-5381.2010.01022.X

13 July 2024

British Journal of Pharmacology

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

162

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

237-254

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Apoptotic effects of protocatechuic acid in human breast, lung, liver, cervix, and prostate cancer cells: potential mechanisms of action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012419

6 July 2018

Rho GTPase function in tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012419

6 July 2018

Gaseous nitrogen oxide promotes human lung cancer cell line A549 migration, invasion, and metastasis via iNOS-mediated MMP-2 production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012419

6 July 2018

Clinicopathological significance of MMP-2 and its specific inhibitor TIMP-2 in gastric cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012419

6 July 2018

p37 from Mycoplasma hyorhinis promotes cancer cell invasiveness and metastasis through activation of MMP-2 and followed by phosphorylation of EGFR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012419

6 July 2018

Apoptotic effect of 3,4-dihydroxybenzoic acid on human gastric carcinoma cells involving JNK/p38 MAPK signaling activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012419

6 July 2018

Effects of natural and novel synthetic jasmonates in experimental metastatic melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012419

6 July 2018

Up-regulation of RhoB by glucocorticoids and its effects on the cell proliferation and NF-kappaB transcriptional activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012419

6 July 2018

Involvement of protein kinase Cepsilon in the negative regulation of Akt activation stimulated by granulocyte colony-stimulating factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012419

6 July 2018

Curcumin suppresses phorbol ester-induced matrix metalloproteinase-9 expression by inhibiting the PKC to MAPK signaling pathways in human astroglioma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012419

6 July 2018

Alternative splicing of MDM2 mRNA in lung carcinomas and lung cell lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012419

6 July 2018

Akt mediates Ras downregulation of RhoB, a suppressor of transformation, invasion, and metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012419

6 July 2018

Raf and RhoA cooperate to transform intestinal epithelial cells and induce growth resistance to transforming growth factor beta.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012419

6 July 2018

Antiproliferative and apoptotic effects of selective phenolic acids on T47D human breast cancer cells: potential mechanisms of action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012419

6 July 2018

Modulation of phosphatidylinositol-3-kinase/protein kinase B- and mitogen-activated protein kinase-pathways by tea polyphenols in human prostate cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012419

6 July 2018

Molecular mechanisms of glioma invasiveness: the role of proteases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012419

6 July 2018

The organ microenvironment and cancer metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012419

6 July 2018

Osteopontin induces nuclear factor kappa B-mediated promatrix metalloproteinase-2 activation through I kappa B alpha /IKK signaling pathways, and curcumin (diferulolylmethane) down-regulates these pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012419

6 July 2018

A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012419

6 July 2018

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012419

6 July 2018

Matrix metalloproteinases in lung biology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012419

6 July 2018

Inhibition of insulin-induced activation of Akt by a kinase-deficient mutant of the epsilon isozyme of protein kinase C

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012419

6 July 2018

AKT activation up-regulates insulin-like growth factor I receptor expression and promotes invasiveness of human pancreatic cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012419

6 July 2018

Inhibitory effects of protocatechuic acid on the post-initiation phase of hamster pancreatic carcinogenesis induced by N-nitrosobis(2-oxopropyl)amine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012419

6 July 2018

Induction of apoptosis in prostate cancer cell lines by a flavonoid, baicalin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012419

6 July 2018

Regulation of matrix metalloproteinase expression in tumor invasion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012419

6 July 2018

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012419

6 July 2018

Chemoprevention of diethylnitrosamine-induced hepatocarcinogenesis by a simple phenolic acid protocatechuic acid in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012419

6 July 2018

The ras-related small GTP-binding protein RhoB is immediate-early inducible by DNA damaging treatments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012419

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012419

6 July 2018

The beneficial and hazardous effects of simple phenolic compounds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012419

6 July 2018

Silibinin inhibits the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2010.01022.X

21 January 2018

Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2010.01022.X

21 January 2018

Benzyl isothiocyanate inhibits metalloproteinase-2/-9 expression by suppressing the mitogen-activated protein kinase in SK-Hep1 human hepatoma cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2010.01022.X

21 January 2018

Suppression of azoxymethane-induced rat colon aberrant crypt foci by dietary protocatechuic acid.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2010.01022.X

21 January 2018

Increase of RhoB in gamma-radiation-induced apoptosis is regulated by c-Jun N-terminal kinase in Jurkat T cells.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2010.01022.X

21 January 2018

Chemoprevention of digestive organs carcinogenesis by natural product protocatechuic acid.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2010.01022.X

21 January 2018

Green tea polyphenol epigallocatechin-3-gallate suppresses rat hepatic stellate cell invasion by inhibition of MMP-2 expression and its activation.

1 reference

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21 January 2018

Induction of apoptosis in HL-60 cells by eicosapentaenoic acid (EPA) is associated with downregulation of bcl-2 expression

1 reference

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A comparison of scavenging abilities of antioxidants against hydroxyl radicals

1 reference

https://pubmed.ncbi.nlm.nih.gov/20840540

12 December 2020

based on heuristic

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Phenolic compounds from Duchesnea chrysantha and their cytotoxic activities in human cancer cell

1 reference

https://pubmed.ncbi.nlm.nih.gov/20840540

12 December 2020

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Antioxidant activity of 3,4-DHPEA-EA and protocatechuic acid: a comparative assessment with other olive oil biophenols

1 reference

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12 December 2020

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Induction of apoptosis by hibiscus protocatechuic acid in human leukemia cells via reduction of retinoblastoma (RB) phosphorylation and Bcl-2 expression

1 reference

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12 December 2020

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Reactive oxygen species scavenging activity of Du-zhong (Eucommia ulmoides oliv.) and its active compounds

1 reference

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Protective action of seven natural phenolic compounds against peroxidative damage to biomembranes

1 reference

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12 December 2020

based on heuristic

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High performance liquid chromatographic determination of phenolic acids in fruits and vegetables

1 reference

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12 December 2020

based on heuristic

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Hibiscus protocatechuic acid protects against oxidative damage induced by tert-butylhydroperoxide in rat primary hepatocytes

1 reference

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12 December 2020

based on heuristic

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Characterization of potentially chemopreventive phenols in extracts of brown rice that inhibit the growth of human breast and colon cancer cells

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Respiratory-related neuronal activity in the nucleus ambiguus-retroambigualis complex and their responses to peripheral and central stimulation in the rat.

29

1 reference

10.1111/J.1476-5381.2010.01022.X

https://api.crossref.org/works/10.1111/J.1476-5381.2010.01022.X

13 July 2024

Identifiers

10.1111/J.1476-5381.2010.01022.X

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

ResearchGate publication ID

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