(Q48446950)

English

Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter.

scientific article published on 14 August 2006

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16909123%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter (English)

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28 December 2019

histone acetylation

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inferred from title

8

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28 December 2019

author name string

Delarue FL

1

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28 December 2019

Adnane J

2

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28 December 2019

Joshi B

3

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28 December 2019

Blaskovich MA

4

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28 December 2019

Wang DA

5

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28 December 2019

Hawker J

6

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28 December 2019

Bizouarn F

7

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28 December 2019

Zhu K

9

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28 December 2019

Hamilton AD

10

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28 December 2019

Chellappan S

11

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28 December 2019

Sebti SM

12

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28 December 2019

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14 August 2006

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28 December 2019

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28 December 2019

26

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28 December 2019

5

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28 December 2019

633-640

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28 December 2019

https://scigraph.springernature.com/pub.10.1038/sj.onc.1209819

0 references

Inhibition of farnesyltransferase increases TGFbeta type II receptor expression and enhances the responsiveness of human cancer cells to TGFbeta.

1 reference

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21 January 2018

RhoB prenylation is driven by the three carboxyl-terminal amino acids of the protein: evidenced in vivo by an anti-farnesyl cysteine antibody

1 reference

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21 January 2018

A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis

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21 January 2018

Reversal of methylation-mediated repression with short-chain fatty acids: evidence for an additional mechanism to histone deacetylation

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21 January 2018

Transcription factor FoxA (HNF3) on a nucleosome at an enhancer complex in liver chromatin.

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Direct binding of apoptosis signal-regulating kinase 1 to retinoblastoma protein: novel links between apoptotic signaling and cell cycle machinery

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The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis

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21 January 2018

Ras-related GTPase RhoB forces alkylation-induced apoptotic cell death

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21 January 2018

The ras-related small GTP-binding protein RhoB is immediate-early inducible by DNA damaging treatments

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21 January 2018

Prohibitin Induces the Transcriptional Activity of p53 and Is Exported from the Nucleus upon Apoptotic Signaling

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21 January 2018

The potential of farnesyltransferase inhibitors as cancer chemotherapeutics

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21 January 2018

Acetylation of a specific promoter nucleosome accompanies activation of the epsilon-globin gene by beta-globin locus control region HS2.

1 reference

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21 January 2018

Consequences of mevalonate depletion. Differential transcriptional, translational, and post-translational up-regulation of Ras, Rap1a, RhoA, AND RhoB.

1 reference

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21 January 2018

Isoprenoids influence expression of Ras and Ras-related proteins

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21 January 2018

Discovery of (R)-7-cyano-2,3,4, 5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3- (phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a farnesyltransferase inhibitor with potent preclinical antitumor activity

1 reference

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21 January 2018

EGFR, ErbB2 and Ras but not Src suppress RhoB expression while ectopic expression of RhoB antagonizes oncogene-mediated transformation

1 reference

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21 January 2018

Akt mediates Ras downregulation of RhoB, a suppressor of transformation, invasion, and metastasis

1 reference

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21 January 2018

Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice

1 reference

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21 January 2018

Non-Ras targets of farnesyltransferase inhibitors: focus on Rho.

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21 January 2018

Ras CAAX Peptidomimetic FTI-277 Selectively Blocks Oncogenic Ras Signaling by Inducing Cytoplasmic Accumulation of Inactive Ras-Raf Complexes

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21 January 2018

Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines

1 reference

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21 January 2018

RhoB alteration is necessary for apoptotic and antineoplastic responses to farnesyltransferase inhibitors

1 reference

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21 January 2018

Loss of RhoB expression in human lung cancer progression.

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21 January 2018

Farnesyltransferase inhibitors induce DNA damage via reactive oxygen species in human cancer cells

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21 January 2018

Actin' up: RhoB in cancer and apoptosis

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21 January 2018

Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo

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21 January 2018

Farnesyltransferase and geranylgeranyltransferase I inhibitors in cancer therapy: important mechanistic and bench to bedside issues

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21 January 2018

Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts

1 reference

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21 January 2018

The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner

1 reference

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21 January 2018

Histone deacetylase 1 represses the small GTPase RhoB expression in human nonsmall lung carcinoma cell line

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21 January 2018

Use of chromatin immunoprecipitation to clone novel E2F target promoters

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21 January 2018

K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

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21 January 2018

Protein prenylation: molecular mechanisms and functional consequences

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Rho family proteins and Ras transformation: the RHOad less traveled gets congested.

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Both farnesylated and geranylgeranylated RhoB inhibit malignant transformation and suppress human tumor growth in nude mice

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Opinion: Searching for the elusive targets of farnesyltransferase inhibitors

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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