(Q40837781)

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Inhibition of farnesyltransferase increases TGFbeta type II receptor expression and enhances the responsiveness of human cancer cells to TGFbeta.

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11114730%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

Inhibition of farnesyltransferase increases TGFbeta type II receptor expression and enhances the responsiveness of human cancer cells to TGFbeta (English)

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Europe PubMed Central

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2 November 2019

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2 November 2019

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Adnane J

1

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2 November 2019

Bizouarn FA

2

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2 November 2019

Chen Z

3

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2 November 2019

Hamilton AD

5

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2 November 2019

Munoz-Antonia T

6

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2 November 2019

Sebti SM

7

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2 November 2019

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1 November 2000

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2 November 2019

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9

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2 November 2019

19

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2 November 2019

48

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2 November 2019

5525-5533

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2 November 2019

p21(WAF1/CIP1) is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming growth factor beta- and Sp1-responsive element: involvement of the small GTPase rhoA.

1 reference

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21 January 2018

A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis

1 reference

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21 January 2018

Smad4/DPC4 silencing and hyperactive Ras jointly disrupt transforming growth factor-beta antiproliferative responses in colon cancer cells.

1 reference

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21 January 2018

Protein prenyltransferases

1 reference

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21 January 2018

Independent changes in type I and type II receptors for transforming growth factor beta induced by bone morphogenetic protein 2 parallel expression of the osteoblast phenotype

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Glucocorticoid regulation of transforming growth factor beta 1 activity and binding in osteoblast-enriched cultures from fetal rat bone

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21 January 2018

Involvement of protein kinase C and rho GTPase in the nuclear signalling pathway by transforming growth factor-beta1 in rat-2 fibroblast cells

1 reference

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21 January 2018

Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein

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21 January 2018

Smads: transcriptional activators of TGF-beta responses

1 reference

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21 January 2018

RhoB is stabilized by transforming growth factor beta and antagonizes transcriptional activation

1 reference

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21 January 2018

The ras-related small GTP-binding protein RhoB is immediate-early inducible by DNA damaging treatments

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21 January 2018

The potential of farnesyltransferase inhibitors as cancer chemotherapeutics

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21 January 2018

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

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21 January 2018

Transforming Growth Factor-β Signaling in Epithelial Cells

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21 January 2018

TGF-beta signaling and cancer: structural and functional consequences of mutations in Smads.

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21 January 2018

The ras-related gene rhoB is an immediate-early gene inducible by v-Fps, epidermal growth factor, and platelet-derived growth factor in rat fibroblasts

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21 January 2018

The role of transforming growth factor beta in glioma progression

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21 January 2018

Development of TGF-beta resistance during malignant progression

1 reference

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21 January 2018

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms

1 reference

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21 January 2018

Farnesyltransferase inhibitors. Preclinical development

1 reference

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21 January 2018

Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1

1 reference

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21 January 2018

A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras

1 reference

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21 January 2018

The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase

1 reference

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21 January 2018

Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2

1 reference

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21 January 2018

Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.

1 reference

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21 January 2018

Non-Ras targets of farnesyltransferase inhibitors: focus on Rho.

1 reference

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21 January 2018

Ras CAAX Peptidomimetic FTI-277 Selectively Blocks Oncogenic Ras Signaling by Inducing Cytoplasmic Accumulation of Inactive Ras-Raf Complexes

1 reference

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21 January 2018

Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines

1 reference

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21 January 2018

Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells

1 reference

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21 January 2018

MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

Tumor suppressor activity of the TGF-beta pathway in human cancers

1 reference

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21 January 2018

Escape from transforming growth factor beta control and oncogene cooperation in skin tumor development

1 reference

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21 January 2018

Extracellular signal-regulated kinase and the small GTP-binding protein, Rac, contribute to the effects of transforming growth factor-beta1 on gene expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

Role of Ras and Mapks in TGFbeta signaling

1 reference

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21 January 2018

Farnesyltransferase inhibitor-induced regression of mammary tumors in TGF alpha and TGF alpha/neu transgenic mice correlates with inhibition of map kinase and p70s6 kinase phosphorylation

1 reference

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21 January 2018

TGF-beta and cancer.

1 reference

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21 January 2018

Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo

1 reference

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21 January 2018

Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development

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21 January 2018

Inhibition of ras prenylation: A novel approach to cancer chemotherapy

1 reference

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21 January 2018

Isolation and characterization of Kirsten murine sarcoma virus-transformed mouse keratinocytes resistant to transforming growth factor beta

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Phosphorylation of Ser465 and Ser467 in the C Terminus of Smad2 Mediates Interaction with Smad4 and Is Required for Transforming Growth Factor-β Signaling

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21 January 2018

The transforming growth factor-betas: past, present, and future

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21 January 2018

Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts

1 reference

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Extracellular matrix-associated transforming growth factor-beta: role in cancer cell growth and invasion.

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Overexpression of transforming growth factor beta-type II receptor reduces tumorigenicity and metastastic potential of K-ras-transformed thyroid cells.

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Interaction of transforming growth factor-beta receptor I with farnesyl-protein transferase-alpha in yeast and mammalian cells

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21 January 2018

K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

1 reference

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TGF beta signals through a heteromeric protein kinase receptor complex

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Receptor-associated Mad homologues synergize as effectors of the TGF-beta response

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Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription

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21 January 2018

Characterization of human FAST-1, a TGF beta and activin signal transducer

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Evidence for a role of Rho-like GTPases and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in transforming growth factor beta-mediated signaling

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The MEK pathway is required for stimulation of p21(WAF1/CIP1) by transforming growth factor-beta

1 reference

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Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

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Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB

1 reference

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based on heuristic

inferred from DOI database lookup

Pre-clinical development of farnesyltransferase inhibitors

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7 January 2021

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Protein prenylation: a mediator of protein-protein interactions

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Cancer gets Mad: DPC4 and other TGFbeta pathway genes in human cancer

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Farnesyltransferase inhibitors: targeting the molecular basis of cancer

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Cross-talk between the Smad1 and Ras/MEK signaling pathways for TGFbeta

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