(Q34090957)

30 July 2017

1 reference

title

Farnesyltransferase and geranylgeranyltransferase I inhibitors in cancer therapy: important mechanistic and bench to bedside issues (English)

1 reference

30 July 2017

Sebti SM

1

1 reference

PubMed ID

11093352

30 July 2017

Hamilton AD

series ordinal

2

1 reference

PubMed ID

11093352

30 July 2017

language of work or name

English

0 references

publication date

1 December 2000

1 reference

Expert Opinion on Investigational Drugs

30 July 2017

1 reference

30 July 2017

9

1 reference

30 July 2017

2767-2782

1 reference

30 July 2017

12

1 reference

Protein prenylation: molecular mechanisms and functional consequences

30 July 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.12.2767

Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.12.2767

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.12.2767

Rho family proteins and Ras transformation: the RHOad less traveled gets congested.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.12.2767

Anticancer activity of farnesyltransferase and geranylgeranyltransferase I inhibitors: prospects for drug development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.12.2767

The potential of farnesyltransferase inhibitors as cancer chemotherapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.12.2767

Inhibition of Ras prenylation: a novel approach to cancer chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.12.2767

Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.12.2767

Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.12.2767

Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.12.2767

Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.12.2767

K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.12.2767

Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.12.2767

Inhibition of Ras and related G-proteins as a therapeutic strategy for blocking malignant glioma growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.12.2767

Inhibition of Ras and related guanosine triphosphate-dependent proteins as a therapeutic strategy for blocking malignant glioma growth: II--preclinical studies in a nude mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.12.2767

A role for Rho in Ras transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.12.2767

RhoB alteration is necessary for apoptotic and antineoplastic responses to farnesyltransferase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.12.2767

Farnesyltransferase inhibitors induce cytochrome c release and caspase 3 activation preferentially in transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.12.2767

The phosphoinositide 3-OH kinase/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.12.2767

The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.12.2767

A farnesyl-protein transferase inhibitor induces p21 expression and G1 block in p53 wild type tumor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.12.2767

Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.12.2767

Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.12.2767

10.1517/13543784.9.12.2767

21 January 2018

Identifiers

DOI

1 reference

30 July 2017

1 reference

PubMed ID

11093352