(Q53853231)

21 May 2018

title

Anticancer activity of farnesyltransferase and geranylgeranyltransferase I inhibitors: prospects for drug development. (English)

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21 May 2018

author name string

Sebti SM

series ordinal

1

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21 May 2018

Hamilton AD

series ordinal

2

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21 May 2018

language of work or name

English

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publication date

1 November 1997

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21 May 2018

Expert Opinion on Investigational Drugs

published in

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21 May 2018

volume

6

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21 May 2018

page(s)

1711-1714

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21 May 2018

issue

11

1 reference

21 May 2018

https://api.crossref.org/works/10.1517%2F13543784.6.11.1711

1 reference

Inhibition of Ras prenylation: a novel approach to cancer chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.11.1711

The potential of farnesyltransferase inhibitors as cancer chemotherapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.11.1711

Protein prenylation: molecular mechanisms and functional consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.11.1711

Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.11.1711

Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.11.1711

Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.11.1711

Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.11.1711

Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.11.1711

Novel tricyclic inhibitors of farnesyl protein transferase. Biochemical characterization and inhibition of Ras modification in transfected Cos cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.11.1711

Phosphinyl acid-based bisubstrate analog inhibitors of Ras farnesyl protein transferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.11.1711

Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.11.1711

Farnesyltransferase as a target for anticancer drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.11.1711

Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.11.1711

Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.11.1711

Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.11.1711

K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.11.1711

Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.11.1711

Inhibition of protein geranylgeranylation causes a superinduction of nitric-oxide synthase-2 by interleukin-1beta in vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.11.1711

The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.11.1711

10.1517/13543784.6.11.1711

21 January 2018

Identifiers

DOI

1 reference

21 May 2018

PubMed ID

15989575

1 reference

21 May 2018