(Q47761479)

5 February 2018

title

A farnesyl-protein transferase inhibitor induces p21 expression and G1 block in p53 wild type tumor cells. (English)

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5 February 2018

author name string

Sepp-Lorenzino L

series ordinal

1

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5 February 2018

Rosen N

series ordinal

2

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5 February 2018

language of work or name

English

0 references

publication date

1 August 1998

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5 February 2018

Journal of Biological Chemistry

number of pages

9

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based on heuristic

inferred from page(s)

published in

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5 February 2018

volume

273

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5 February 2018

page(s)

20243-20251

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5 February 2018

issue

32

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5 February 2018

Farnesyltransferase inhibitors and anti-Ras therapy

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.32.20243

Protein prenylation: molecular mechanisms and functional consequences

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The potential of farnesyltransferase inhibitors as cancer chemotherapeutics

21 January 2018

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Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice

21 January 2018

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Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton

21 January 2018

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Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro.

21 January 2018

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Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor

21 January 2018

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Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo

21 January 2018

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K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

21 January 2018

1 reference

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Flow cytometric analysis of G1- and G2/M-phase subpopulations in mammalian cell nuclei using side scatter and DNA content measurements

21 January 2018

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WAF1, a potential mediator of p53 tumor suppression

21 January 2018

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The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner

21 January 2018

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A question of balance: the role of cyclin-kinase inhibitors in development and tumorigenesis

21 January 2018

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Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

21 January 2018

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The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

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Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme

21 January 2018

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Mechanism of inhibition of proliferating cell nuclear antigen-dependent DNA synthesis by the cyclin-dependent kinase inhibitor p21.

21 January 2018

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A non-enzymatic p21 protein inhibitor of stress-activated protein kinases

21 January 2018

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Subcellular distribution of p21 and PCNA in normal and repair-deficient cells following DNA damage

21 January 2018

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The human papilloma virus 16E6 gene sensitizes human mammary epithelial cells to apoptosis induced by DNA damage

21 January 2018

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Hypermutability and mismatch repair deficiency in RER+ tumor cells

21 January 2018

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DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

21 January 2018

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Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21

21 January 2018

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Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1

21 January 2018

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Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

21 January 2018

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Characterization of Ha-ras, N-ras, Ki-Ras4A, and Ki-Ras4B as in vitro substrates for farnesyl protein transferase and geranylgeranyl protein transferase type I

21 January 2018

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Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB

21 January 2018

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Cip1 blocks the initiation of DNA replication in Xenopus extracts by inhibition of cyclin-dependent kinases

21 January 2018

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p21(WAF1/CIP1) response to genotoxic agents in wild-type TP53 expressing breast primary tumours

21 January 2018

1 reference

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p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage

21 January 2018

1 reference

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Association of insulin-like growth-factor-I-induced DNA synthesis with phosphorylation and nuclear exclusion of p53 in human breast cancer MCF-7 cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.273.32.20243

1 reference

5 February 2018

PubMed ID

9685373

1 reference

5 February 2018