(Q34457281)

2 August 2017

title

Klotho deficiency causes vascular calcification in chronic kidney disease (English)

1 reference

2 August 2017

main subject

vascular calcification

1 reference

6

Makoto Kuro-o

1 reference

2 August 2017

7

Orson W Moe

1 reference

2 August 2017

Ming Chang Hu

1

1 reference

2 August 2017

Mingjun Shi

2

1 reference

2 August 2017

Jianning Zhang

3

1 reference

2 August 2017

Henry Quiñones

4

1 reference

2 August 2017

Carolyn Griffith

5

1 reference

2 August 2017

publication date

29 November 2010

1 reference

Journal of the American Society of Nephrology

2 August 2017

published in

1 reference

2 August 2017

volume

22

1 reference

2 August 2017

issue

1

1 reference

2 August 2017

page(s)

124-136

1 reference

Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule

2 August 2017

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1 reference

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In vivo genetic evidence for suppressing vascular and soft-tissue calcification through the reduction of serum phosphate levels, even in the presence of high serum calcium and 1,25-dihydroxyvitamin d levels

6 July 2018

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6 July 2018

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Circulating fibroblast growth factor 23 in patients with end-stage renal disease treated by peritoneal dialysis is intact and biologically active

6 July 2018

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Klotho reduces apoptosis in experimental ischaemic acute kidney injury via HSP-70.

6 July 2018

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Klotho is a substrate for alpha-, beta- and gamma-secretase

6 July 2018

1 reference

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Identification of a novel function of PiT1 critical for cell proliferation and independent of its phosphate transport activity.

6 July 2018

1 reference

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Klotho gene delivery prevents the progression of spontaneous hypertension and renal damage

6 July 2018

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6 July 2018

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Vascular smooth muscle cell calcification and SLC20 inorganic phosphate transporters: effects of PDGF, TNF-alpha, and Pi.

6 July 2018

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Emerging therapies for chronic kidney disease: what is their role?

6 July 2018

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Urinary endothelin-1 in chronic kidney disease and as a marker of disease activity in lupus nephritis

6 July 2018

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Phosphorus binders and survival on hemodialysis

6 July 2018

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Urinary fatty acid-binding protein 1: an early predictive biomarker of kidney injury.

6 July 2018

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Association of renal function with cardiac calcifications in older adults: the cardiovascular health study

6 July 2018

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In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23) -mediated regulation of systemic phosphate homeostasis

6 July 2018

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A rat model of chronic kidney disease-mineral bone disorder

6 July 2018

1 reference

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Chronic kidney disease as a predictor of cardiovascular disease (from the Framingham Heart Study)

6 July 2018

1 reference

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The mechanism of phosphorus as a cardiovascular risk factor in CKD

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

A translocation causing increased alpha-klotho level results in hypophosphatemic rickets and hyperparathyroidism

6 July 2018

1 reference

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Biomarkers for the diagnosis and risk stratification of acute kidney injury: a systematic review.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Vascular Bmp Msx2 Wnt signaling and oxidative stress in arterial calcification

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Prevalence of chronic kidney disease in the United States

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Fetuin A stabilizes m-calpain and facilitates plasma membrane repair

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Hyperphosphatemia: effects on bone metabolism and cardiovascular risk.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Vascular aging and geriatric patient

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Cystatin C as a risk factor for outcomes in chronic kidney disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

The emerging role of the fibroblast growth factor-23-klotho axis in renal regulation of phosphate homeostasis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Deciphering PiT transport kinetics and substrate specificity using electrophysiology and flux measurements

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Osteoblast autonomous Pi regulation via Pit1 plays a role in bone mineralization

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Insulin attenuates vascular smooth muscle calcification but increases vascular smooth muscle cell phosphate transport

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

An introduction to biomarkers: applications to chronic kidney disease.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Characterization of phosphate transport in rat vascular smooth muscle cells: implications for vascular calcification.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Type II Na+-Pi cotransporters in osteoblast mineral formation: regulation by inorganic phosphate

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Amelioration of progressive renal injury by genetic manipulation of Klotho gene

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Klotho converts canonical FGF receptor into a specific receptor for FGF23

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Molecular mechanisms mediating vascular calcification: role of matrix Gla protein.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Klotho protein promotes adipocyte differentiation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Role of the sodium-dependent phosphate cotransporter, Pit-1, in vascular smooth muscle cell calcification

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Regulation of fibroblast growth factor-23 signaling by klotho

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Suppression of aging in mice by the hormone Klotho

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Pathogenesis of vascular calcification in chronic kidney disease.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Klotho protein activates the PKC pathway in the kidney and testis and suppresses 25-hydroxyvitamin D3 1alpha-hydroxylase gene expression.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Adiponectin in chronic kidney disease is related more to metabolic disturbances than to decline in renal function

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Regulation of phosphate (Pi) transport and NaPi-III transporter (Pit-1) mRNA in rat osteoblasts.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Multiple signaling pathways converge on the Cbfa1/Runx2 transcription factor to regulate osteoblast differentiation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Renal bone disease: a new conceptual framework for the interpretation of bone histomorphometry

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Hyperphosphataemia in renal failure: causes, consequences and current management

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Arterial calcification in diabetes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

In vivo klotho gene transfer ameliorates angiotensin II-induced renal damage

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Consequences of hyperphosphatemia and elevated levels of the calcium-phosphorus product in dialysis patients

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Arterial calcification: a review of mechanisms, animal models, and the prospects for therapy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Phosphate regulation of vascular smooth muscle cell calcification

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Molecular cloning of rat klotho cDNA: markedly decreased expression of klotho by acute inflammatory stress

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Microalbuminuria in elderly hyperglycaemic patients and controls.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Decreased expression of klotho gene in uremic atherosclerosis in apolipoprotein E-deficient mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Blood-pressure control and delay in progression of kidney disease in children

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Prevalence of anemia according to stage of chronic kidney disease in a large screening cohort of Japanese.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Vascular calcification: the killer of patients with chronic kidney disease

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Blockage of the renin-angiotensin system attenuates mortality but not vascular calcification in uremic rats: sevelamer carbonate prevents vascular calcification

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

N-acetyl-beta-D-glucosaminidase index as an early biomarker for chronic kidney disease in cats with hyperthyroidism

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Vascular calcifications in homozygote familial hypercholesterolemia

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Non-traditional risk factors predict coronary calcification in chronic kidney disease in a population-based cohort

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Vasopressin stimulates Na-dependent phosphate transport and calcification in rat aortic smooth muscle cells.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Up-regulation of Cbfa1 and Pit-1 in calcified artery of uraemic rats with severe hyperphosphataemia and secondary hyperparathyroidism.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Oxidative stress decreases klotho expression in a mouse kidney cell line.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Cardiovascular calcification in Hispanic Americans (HA) with chronic kidney disease (CKD) due to type 2 diabetes.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Serum phosphate levels and mortality risk among people with chronic kidney disease

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Transport-deficient Pit2 phosphate transporters still modify cell surface oligomers structure in response to inorganic phosphate

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Phosphate-induced vascular calcification: role of pyrophosphate and osteopontin

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Phosphate uptake and PiT-1 protein expression in rat skeletal muscle

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

The effects of sevelamer hydrochloride and calcium carbonate on kidney calcification in uremic rats

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Smooth muscle cell phenotypic transition associated with calcification: upregulation of Cbfa1 and downregulation of smooth muscle lineage markers.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Severely reduced production of klotho in human chronic renal failure kidney.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014041

Managing phosphate retention: is a change necessary?

27 October 2018

1 reference

12 December 2020

Regulated expression of hypoxia-inducible factors during postnatal and postpneumonectomy lung growth

1 reference

12 December 2020

gamma-Glutamyltransferase as a predictor of chronic kidney disease in nonhypertensive and nondiabetic Korean men

1 reference

12 December 2020

Correlation between hyperphosphatemia and type II Na-Pi cotransporter activity in klotho mice

1 reference

12 December 2020

Role of hyperphosphatemia and 1,25-dihydroxyvitamin D in vascular calcification and mortality in fibroblastic growth factor 23 null mice

1 reference

12 December 2020

Mineral Metabolism and Vascular Damage in Children on Dialysis

1 reference

12 December 2020

Regulation of fibroblast growth factor-23 in chronic kidney disease

1 reference

12 December 2020

Hypertension: the message of World Kidney Day 2009

1 reference

12 December 2020

Downregulation of the Klotho gene in the kidney under sustained circulatory stress in rats

1 reference

12 December 2020

Role of calcification inhibitors in the pathogenesis of vascular calcification in chronic kidney disease (CKD)

1 reference

12 December 2020

Establishment of the anti-Klotho monoclonal antibodies and detection of Klotho protein in kidneys

1 reference

12 December 2020

Identifiers

DOI

10.1681/ASN.2009121311

1 reference

2 August 2017

1 reference

2 August 2017

1 reference