(Q34458332)

2 August 2017

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title

Pharmacogenetics: the therapeutic drug monitoring of the future? (English)

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2 August 2017

Ensom MH

1

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2 August 2017

Chang TK

series ordinal

2

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2 August 2017

Patel P

series ordinal

3

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2 August 2017

publication date

1 January 2001

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Clinical Pharmacokinetics

2 August 2017

published in

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2 August 2017

volume

40

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2 August 2017

issue

11

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2 August 2017

page(s)

783-802

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High clearance of (S)-warfarin in a warfarin-resistant subject

2 August 2017

cites work

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https://api.crossref.org/works/10.2165%2F00003088-200140110-00001

Codeine O-demethylation co-segregates with polymorphic debrisoquine hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00003088-200140110-00001

Severe Prolonged Hypoglycemia Following Tolbutamide and Carbutamide Treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00003088-200140110-00001

Metabolism of theophylline by cDNA-expressed human cytochromes P-450.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00003088-200140110-00001

Pilot study of the cytochrome P450-2D6 genotype in a psychiatric state hospital.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00003088-200140110-00001

A Bayesian feedback method of aminoglycoside dosing.

21 January 2018

1 reference

12 December 2020

Positive impact of a therapeutic drug-monitoring program on total aminoglycoside dose and cost of hospitalization

1 reference

12 December 2020

Roles of cytochrome P4502C9 and cytochrome P4502C19 in the stereoselective metabolism of phenytoin to its major metabolite

1 reference

12 December 2020

Clinical implications of antidepressant pharmacokinetics and pharmacogenetics

1 reference

12 December 2020

A randomized controlled trial of computerized pharmacokinetic theophylline dosing versus empiric physician dosing

1 reference

12 December 2020

Relationship of polymorphism in CYP2C9 to genetic susceptibility to diclofenac-induced hepatitis

1 reference

12 December 2020

Inventing the pharmacogenomics business

1 reference

12 December 2020

An evaluation of a clinical pharmacokinetic service for serum digoxin levels

1 reference

12 December 2020

Human acetyltransferase polymorphisms

1 reference

12 December 2020

Recombinant humanized anti-HER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts

1 reference

12 December 2020

Pharmacogenomics: tailoring drug therapy

1 reference

12 December 2020

Impact of P450 genetic polymorphism on the first-pass extraction of cardiovascular and neuroactive drugs

1 reference

12 December 2020

Does accepting pharmacokinetic recommendations impact hospitalization? A cost-benefit analysis

1 reference

12 December 2020

Clinical pharmacokinetics: a comprehensive system for therapeutic drug monitoring and prescribing

1 reference

12 December 2020

Impact of pharmacogenomics on the clinical laboratory

1 reference

12 December 2020

The MDR1 gene product, P-glycoprotein, mediates the transport of the cardiac glycoside, digoxin

1 reference

12 December 2020

Inheritance of poor phenytoin parahydroxylation capacity in a Dutch family

1 reference

12 December 2020

Collaboration between pharmacy and laboratory: defining total allowable error limits for therapeutically monitored drugs.

1 reference

12 December 2020

Roles of two allelic variants (Arg144Cys and Ile359Leu) of cytochrome P4502C9 in the oxidation of tolbutamide and warfarin by human liver microsomes

1 reference

12 December 2020

Trastuzumab, a recombinant DNA-derived humanized monoclonal antibody, a novel agent for the treatment of metastatic breast cancer

1 reference

12 December 2020

The relevance of a First-World therapeutic drug monitoring service to the treatment of epilepsy in Third-World conditions

1 reference

12 December 2020

Inheritance of phenytoin hypometabolism: a kinetic study of one family

1 reference

12 December 2020

CYP2C19 genotype-related efficacy of omeprazole for the treatment of infection caused by Helicobacter pylori

1 reference

12 December 2020

Polymorphic O-demethylation of codeine

1 reference

12 December 2020

Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing

1 reference

12 December 2020

A pilot study on risperidone metabolism: the role of cytochromes P450 2D6 and 3A.

1 reference

12 December 2020

CYP2C19 genotype status and effect of omeprazole on intragastric pH in humans

1 reference

12 December 2020

Pharmacokinetics of nortriptyline and its 10-hydroxy metabolite in Chinese subjects of different CYP2D6 genotypes

1 reference

12 December 2020

CYP2D6 inhibition by fluoxetine, paroxetine, sertraline, and venlafaxine in a crossover study: intraindividual variability and plasma concentration correlations

1 reference

12 December 2020

The physiological function of drug-transporting P-glycoproteins

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12 December 2020

Why pharmacogenomics? Why now?

1 reference

12 December 2020

The history of a comprehensive pharmacokinetic service

1 reference

12 December 2020

Reduction of digoxin toxicity associated with measurement of serum levels. A report from the Boston Collaborative Drug Surveillance Program

1 reference

12 December 2020

Shattuck lecture--medical and societal consequences of the Human Genome Project

1 reference

12 December 2020

Pharmacokinetics of chlorpheniramine, phenytoin, glipizide and nifedipine in an individual homozygous for the CYP2C9*3 allele

1 reference

12 December 2020

Cost analysis of an aminoglycoside pharmacokinetic dosing program.

1 reference

12 December 2020

Prospective comparison of traditional and pharmacokinetic aminoglycoside dosing methods

1 reference

12 December 2020

Sufficient effect of 1-week omeprazole and amoxicillin dual treatment for Helicobacter pylori eradication in cytochrome P450 2C19 poor metabolizers

1 reference

12 December 2020

Expression of cytochrome P450 2D6 in Escherichia coli, purification, and spectral and catalytic characterization

1 reference

12 December 2020

10-Hydroxylation of nortriptyline in white persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes

1 reference

12 December 2020

Extension of a pilot study: impact from the cytochrome P450 2D6 polymorphism on outcome and costs associated with severe mental illness.

1 reference

12 December 2020

Factors affecting the maintenance dose of warfarin

1 reference

12 December 2020

Outcome of patients treated by an aminoglycoside pharmacokinetic dosing service

1 reference

12 December 2020

Impact of vancomycin therapeutic drug monitoring on patient care

1 reference

12 December 2020

Pharmacogenomics: worthy of pharmacy's attention

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12 December 2020

Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians

1 reference

12 December 2020

Increased burn patient survival with individualized dosages of gentamicin

1 reference

12 December 2020

Opportunities and responsibilities in pharmaceutical care

1 reference

12 December 2020

The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine

1 reference

12 December 2020

New technologies and DNA resources for high throughput biology

1 reference

12 December 2020

Impact of a pharmacokinetics consultation service on clinical outcomes in an ambulatory-care epilepsy clinic

1 reference

12 December 2020

High throughput and global approaches to gene expression.

1 reference

12 December 2020

Can pharmacokinetic dosing decrease nephrotoxicity associated with aminoglycoside therapy.

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12 December 2020

Mitochondrial gene mutation is a significant predisposing factor in aminoglycoside ototoxicity.

1 reference

12 December 2020

Detection of a novel cytochrome P-450 1A2 polymorphism (F21L) in Chinese

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12 December 2020

Impaired (S)-warfarin metabolism catalysed by the R144C allelic variant of CYP2C9

1 reference

12 December 2020

Pharmacogenetics of cancer therapy: getting personal

1 reference

12 December 2020

Molecular mechanism of slow acetylation of drugs and carcinogens in humans

1 reference

12 December 2020

The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism

1 reference

12 December 2020

Effect of theophylline pharmacokinetic monitoring service on cost and quality of care

1 reference

12 December 2020

Human P-glycoprotein transports cyclosporin A and FK506.

1 reference

12 December 2020

Individualized pharmacokinetic versus standard dosing of amikacin: a comparison of therapeutic outcomes.

1 reference

12 December 2020

Genetic polymorphism of the CYP2C subfamily and its effect on the pharmacokinetics of phenytoin in Japanese patients with epilepsy

1 reference

12 December 2020

Biochemical, cellular, and pharmacological aspects of the multidrug transporter

1 reference

12 December 2020

Evaluation of a digoxin pharmacokinetic monitoring service in a community hospital

1 reference

12 December 2020

Allelic and functional variability of cytochrome P4502C9.

1 reference

12 December 2020

Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans

1 reference

12 December 2020

Effect of individualized pharmacokinetic dosing on patient outcome.

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12 December 2020

Metabolism of isoniazid in man as related to the occurrence of peripheral neuritis

1 reference

12 December 2020

Human Genome Project and pharmacogenomics--implications for pharmacy

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12 December 2020

Impact of a clinical pharmacokinetic service on patients treated with aminoglycosides: a cost-benefit analysis.

1 reference

12 December 2020

N-acetyltransferases: pharmacogenetics and clinical consequences of polymorphic drug metabolism

1 reference

12 December 2020

Meta-analysis of research on the effect of clinical pharmacokinetics services on therapeutic drug monitoring

1 reference

12 December 2020

Molecular basis for rational megaprescribing in ultrarapid hydroxylators of debrisoquine

1 reference

12 December 2020

Theophylline serum concentration and therapeutic effect in severe acute bronchial obstruction: the optimal use of intravenously administered aminophylline

1 reference

12 December 2020

Pharmacogenetic determination of the effects of codeine and prediction of drug interactions

1 reference

12 December 2020

High blood concentrations of imipramine or clomipramine and therapeutic failure: a case report study using drug monitoring data

1 reference

12 December 2020

Bioactivation of the narcotic drug codeine in human liver is mediated by the polymorphic monooxygenase catalyzing debrisoquine 4-hydroxylation (cytochrome P-450 dbl/bufI)

1 reference

12 December 2020

Serial pharmacokinetic dosing of aminoglycosides: a community hospital experience

1 reference

12 December 2020

Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359 allele as low-Km catalysts of cyclophosphamide and ifosfamide activation.

1 reference

12 December 2020

Pharmacogenomics: translating functional genomics into rational therapeutics

1 reference

12 December 2020

Individualizing Gentamicin Dosage Regimens in Burn Patients with Gram-Negative Septicemia: A Cost–Benefit Analysis

1 reference

12 December 2020

In vitro formation, disposition and toxicity of N-acetoxy-sulfamethoxazole, a potential mediator of sulfamethoxazole toxicity.

1 reference

12 December 2020

Impact of a clinical pharmacokinetic service on patients treated with aminoglycosides for gram-negative infections.

1 reference

12 December 2020

The risk for and severity of bleeding complications in elderly patients treated with warfarin. The National Consortium of Anticoagulation Clinics

1 reference

12 December 2020

Impact of therapeutic drug monitoring of intravenous theophylline regimens on serum theophylline concentrations in the medical intensive care unit

1 reference

12 December 2020

Pharmacogenetics of the human arylamine N-acetyltransferases

1 reference

12 December 2020

A controlled trial of the cost benefit of computerized bayesian aminoglycoside administration.

1 reference

12 December 2020

The effects of genetic polymorphisms of CYP2C9 and CYP2C19 on phenytoin metabolism in Japanese adult patients with epilepsy: studies in stereoselective hydroxylation and population pharmacokinetics

1 reference

12 December 2020

Genetic polymorphism of thiopurine S-methyltransferase: molecular mechanisms and clinical importance

1 reference

12 December 2020

Genetic variation as a guide to drug development

1 reference

12 December 2020

Antidepressants and drug-metabolizing enzymes--expert group report

1 reference

12 December 2020

Enzymatic deficiency in primaquine-sensitive erythrocytes

1 reference

12 December 2020

Extremely rapid hydroxylation of debrisoquine: a case report with implication for treatment with nortriptyline and other tricyclic antidepressants.

1 reference

12 December 2020

A utilization and cost-benefit analysis of an aminoglycoside kinetics monitoring service

1 reference

12 December 2020

Evaluation of a therapeutic drug monitoring program for theophylline in a teaching hospital

1 reference

12 December 2020

Apolipoprotein E genotype and gender influence response to tacrine therapy

1 reference

12 December 2020

DNA chips: the future of biomarkers

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12 December 2020

Pharmacogenetics and pharmacogenomics: why is this relevant to the clinical geneticist?

1 reference

12 December 2020

Therapeutic drug monitoring in a paediatric epilepsy clinic.

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12 December 2020

Pharmacogenomics: a new approach to individual therapy of hypertension?

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12 December 2020

Is therapeutic drug monitoring a case for optimizing clinical outcome and avoiding interactions of the selective serotonin reuptake inhibitors?

1 reference

12 December 2020

Expression of a human liver cytochrome P-450 protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae

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12 December 2020

Pharmacogenetics becomes pharmacogenomics: wake up and get ready

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12 December 2020

Science, medicine, and the future: Pharmacogenetics

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12 December 2020

Influence of cytochrome P-450 CYP2C9 polymorphisms on warfarin sensitivity and risk of over-anticoagulation in patients on long-term treatment.

1 reference

12 December 2020

Pharmacogenetics of tolbutamide metabolism in humans

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12 December 2020

Frequency of cytochrome P450 CYP2C9 variants in a Turkish population and functional relevance for phenytoin

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12 December 2020

CYP2C19 participates in tolbutamide hydroxylation by human liver microsomes

1 reference

12 December 2020

Genetic analysis of the interethnic difference between Chinese and Caucasians in the polymorphic metabolism of debrisoquine and codeine

1 reference

12 December 2020

Pharmacogenetic screening for susceptibility to fetal malformations in women

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12 December 2020

Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

1 reference

12 December 2020

Pharmacogenomics: tailoring the drug to the patient

1 reference

12 December 2020

Pharmacogenetics of antipsychotic treatment: lessons learned from clozapine

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12 December 2020

Clinical trials in pharmacogenetics and pharmacogenomics: methods and applications

1 reference

12 December 2020

Polymorphism of the cytochrome P450 (CYP) 2C9 gene in Japanese epileptic patients: genetic analysis of the CYP2C9 locus

1 reference

12 December 2020

CYP2C9 Ile359 and Leu359 variants: enzyme kinetic study with seven substrates

1 reference

12 December 2020

Genetic polymorphism in MDR-1: a tool for examining allelic expression in normal cells, unselected and drug-selected cell lines, and human tumors.

1 reference

12 December 2020

Therapeutic drug monitoring of psychotropic medications.

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12 December 2020

Lung cancer risk in relation to the CYP2C9 genetic polymorphism among Caucasians in Los Angeles County

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12 December 2020

Anticonvulsant serum levels are useful only if the physician appropriately uses them: an assessment of the impact of providing serum level data to physicians

1 reference

12 December 2020

Stereoselective 4'-hydroxylation of phenytoin: relationship to (S)-mephenytoin polymorphism in Japanese

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12 December 2020

Site-directed mutation studies of human liver cytochrome P-450 isoenzymes in the CYP2C subfamily

1 reference

12 December 2020

Cost-effectiveness analysis of serum vancomycin concentration monitoring in patients with hematologic malignancies

1 reference

12 December 2020

Comparative studies on the catalytic roles of cytochrome P450 2C9 and its Cys- and Leu-variants in the oxidation of warfarin, flurbiprofen, and diclofenac by human liver microsomes

1 reference

12 December 2020

Properties of Opiate-Receptor Binding in Rat Brain

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12 December 2020

Polymorphic hydroxylation of Debrisoquine in man.

1 reference

12 December 2020

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12 December 2020

Individualizing theophylline therapy: the impact of clinical pharmacokinetics on patient outcomes

1 reference

12 December 2020

Functional significance of a C-->A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine

1 reference

12 December 2020

SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome

1 reference

12 December 2020

The Sequence of the Human Genome

1 reference

12 December 2020

Pharmacogenetic prediction of clozapine response

1 reference

12 December 2020

Genetic polymorphism of the CYP2C subfamily and excessive serum phenytoin concentration with central nervous system intoxication

1 reference

12 December 2020

Transitions, part 1: beyond pharmaceutical care

1 reference

12 December 2020

Allelic variants of human cytochrome P450 2C9: baculovirus-mediated expression, purification, structural characterization, substrate stereoselectivity, and prochiral selectivity of the wild-type and I359L mutant forms.

1 reference

12 December 2020

Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications

1 reference

12 December 2020

A randomized controlled clinical trial of pharmacokinetic theophylline dosing

1 reference

12 December 2020

The impact of a therapeutic drug monitoring program for phenytoin

1 reference

12 December 2020

The business of pharmacogenomics

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12 December 2020

Pharmacogenetic diagnostics of cytochrome P450 polymorphisms in clinical drug development and in drug treatment

1 reference

12 December 2020

Codeine and morphine in extensive and poor metabolizers of sparteine: pharmacokinetics, analgesic effect and side effects

1 reference

12 December 2020

Decreased tolbutamide-stimulated insulin secretion in healthy subjects with sequence variants in the high-affinity sulfonylurea receptor gene

1 reference

12 December 2020

Effect of genetic differences in omeprazole metabolism on cure rates for Helicobacter pylori infection and peptic ulcer

1 reference

12 December 2020

Cytochrome P4502C9: an enzyme of major importance in human drug metabolism

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12 December 2020

The cytochrome P450 2D6 (CYP2D6) enzyme polymorphism: screening costs and influence on clinical outcomes in psychiatry

1 reference

12 December 2020

Diphenylhydantoin half-life in man and its inhibition by phenylbutazone: the role of genetic factors

1 reference

12 December 2020

Computer-assisted individualized lidocaine dosage: clinical evaluation and comparison with physician performance

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12 December 2020

Seven years of experience with a pharmacokinetic service

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12 December 2020

Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions

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12 December 2020

INSUFFICIENT PARAPHYDROXYLATION AS A CAUSE OF DIPHENYLHYDANTOIN TOXICITY

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12 December 2020

Establishing an aminoglycoside pharmacokinetic monitoring service in a community hospital.

1 reference

12 December 2020

Challenges in comparing treatment outcome from a prospective with that of a retrospective study: assessing the merit of gentamicin therapeutic drug monitoring in pediatric oncology

1 reference

12 December 2020

Pharmacogenetics and psychopharmacotherapy

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12 December 2020

Induction of drug metabolism in man after rifampicin treatment measured by increased hexobarbital and tolbutamide clearance

1 reference

12 December 2020

Aminoglycoside monitoring: use of a pharmacokinetic service versus physician recommendations

1 reference

12 December 2020

Quick onset of severe abdominal pain after codeine in an ultrarapid metabolizer of debrisoquine

1 reference

12 December 2020

Susceptibility mutations in the mitochondrial small ribosomal RNA gene in aminoglycoside induced deafness

1 reference

12 December 2020

Phenytoin hydroxylation in a healthy Caucasian population: bimodal distribution of hydroxyphenytoin urinary excretion.

1 reference

12 December 2020

Screening for factor V Leiden mutation before prescribing combination oral contraceptives

1 reference

12 December 2020

Catalytic activity of three variants (Ile, Leu, and Thr) at amino acid residue 359 in human CYP2C9 gene and simultaneous detection using single-strand conformation polymorphism analysis

1 reference

12 December 2020

Genetic analysis of CYP2C9 polymorphism in a Japanese population

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12 December 2020

CYP2C19 genotype and phenotype determined with omeprazole in patients with acid-related disorders with and without Helicobacter pylori infection

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12 December 2020

Effect of codeine on gastrointestinal motility in relation to CYP2D6 phenotype*

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12 December 2020

Frequency of cytochrome P450 3A4 variant genotype in transplant population and lack of association with cyclosporin clearance

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12 December 2020

Pharmacogenomics: the promise of personalized medicine

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12 December 2020

Cyclosporine metabolism in human liver: identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs.

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12 December 2020

Cost-benefit analysis of an aminoglycoside monitoring service

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12 December 2020

Pharmacogenomics and the changing face of clinical pharmacology

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12 December 2020

Same incidence of adverse drug events after codeine administration irrespective of the genetically determined differences in morphine formation

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12 December 2020

Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese

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12 December 2020

Correlation between cytochrome P-450 CYP2D6 (CYP2D6) genotype and phenotype

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12 December 2020

Genetic analysis of the human cytochrome P450 CYP2C9 locus

1 reference

12 December 2020

Mitochondrial ribosomal RNA mutation associated with both antibiotic–induced and non–syndromic deafness

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12 December 2020

The CYP2C19 enzyme polymorphism

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12 December 2020

The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans

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12 December 2020

Comparisons between in-vitro and in-vivo metabolism of (S)-warfarin: catalytic activities of cDNA-expressed CYP2C9, its Leu359 variant and their mixture versus unbound clearance in patients with the corresponding CYP2C9 genotypes

1 reference

12 December 2020

Technologies for detecting genetic polymorphisms in pharmacogenomics

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12 December 2020

Impact of decentralized pharmacokinetics consultation service

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12 December 2020

Clinical pharmacokinetics in the 21st century. Does the evidence support definitive outcomes?

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12 December 2020

10.2165/00003088-200140110-00001

Identifiers

DOI

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Dimensions Publication ID

2 August 2017

1002721336

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