(Q34458387)

2 August 2017

title

In vitro cytochrome P450-mediated metabolism of exemestane (English)

1 reference

2 August 2017

2

David A Flockhart

1 reference

2 August 2017

3

Zeruesenay Desta

1 reference

2 August 2017

Landry K Kamdem

1

1 reference

2 August 2017

publication date

28 September 2010

1 reference

Drug Metabolism and Disposition

2 August 2017

published in

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2 August 2017

volume

39

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2 August 2017

issue

1

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2 August 2017

page(s)

98-105

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A review of the use of exemestane in early breast cancer

2 August 2017

cites work

1 reference

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6 July 2018

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Survival and safety of exemestane versus tamoxifen after 2-3 years' tamoxifen treatment (Intergroup Exemestane Study): a randomised controlled trial

6 July 2018

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Clinical implications of CYP3A polymorphisms

6 July 2018

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Drug metabolism and variability among patients in drug response

6 July 2018

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Pharmacokinetics and dose finding of a potent aromatase inhibitor, aromasin (exemestane), in young males

6 July 2018

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Constitutive androstane receptor and pregnane X receptor gene expression in human liver: interindividual variability and correlation with CYP2B6 mRNA levels

6 July 2018

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Ritonavir, efavirenz, and nelfinavir inhibit CYP2B6 activity in vitro: potential drug interactions with bupropion

6 July 2018

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Allelic variants of human cytochrome P450 1A1 (CYP1A1): effect of T461N and I462V substitutions on steroid hydroxylase specificity

6 July 2018

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Exemestane: a review of its use in postmenopausal women with advanced breast cancer

6 July 2018

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Novel metabolic pathway of estrone and 17beta-estradiol catalyzed by cytochrome P-450.

6 July 2018

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Molecular genetics of the human cytochrome P450 monooxygenase superfamily

6 July 2018

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Further characterization of the expression in liver and catalytic activity of CYP2B6.

6 July 2018

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Contribution of human hepatic cytochrome P450 isoforms to regioselective hydroxylation of steroid hormones

6 July 2018

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The molecular basis of genetic polymorphisms of drug metabolism.

6 July 2018

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Functional significance of different human CYP1A1 genotypes

6 July 2018

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Relationship between genotype and function of the human CYP1A1 gene

6 July 2018

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CYP3A gene expression in human gut epithelium

6 July 2018

1 reference

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Human CYP1A1 gene: cosegregation of the enzyme inducibility phenotype and an RFLP

6 July 2018

1 reference

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A liquid chromatography-tandem mass spectrometry method for the simultaneous determination of exemestane and its metabolite 17-dihydroexemestane in human plasma.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014267

Role of polymorphic human cytochrome P450 enzymes in estrone oxidation

27 October 2018

1 reference

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Limited contribution of CYP3A5 to the hepatic 6beta-hydroxylation of testosterone

27 October 2018

1 reference

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Pilot study evaluating the pharmacokinetics, pharmacodynamics, and safety of the combination of exemestane and tamoxifen

27 October 2018

1 reference

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The effects of degree of hepatic or renal impairment on the pharmacokinetics of exemestane in postmenopausal women

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014267

A randomized trial of exemestane after two to three years of tamoxifen therapy in postmenopausal women with primary breast cancer

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014267

The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014267

Mechanism of induction of cytochrome p450 enzymes by the proestrogenic endocrine disruptor pesticide-methoxychlor: interactions of methoxychlor metabolites with the constitutive androstane receptor system.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014267

Cytochrome P450 isoform inhibitors as a tool for the investigation of metabolic reactions catalyzed by human liver microsomes

27 October 2018

1 reference

12 December 2020

Characterization of cytochrome P450 enzymes in human breast tissue from reduction mammaplasties

1 reference

12 December 2020

Genetic polymorphism of human cytochrome p450 involved in drug metabolism

1 reference

12 December 2020

Synthesis and aromatase inhibition by potential metabolites of exemestane (6-methylenandrosta-1,4-diene-3,17-dione)

1 reference

12 December 2020

Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver

1 reference

12 December 2020

Chemoprevention of breast cancer

1 reference

12 December 2020

Identifiers

DOI

10.1124/DMD.110.032276

1 reference

2 August 2017

1 reference

2 August 2017

1 reference