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The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression.
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Europe PubMed Central
PMCID
140723
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12554654%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 December 2019
title
The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression
(English)
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PMCID
140723
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12554654%20AND%20SRC:MED&resulttype=core&format=json
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17 December 2019
author
Andrés Alcover
series ordinal
3
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Europe PubMed Central
PMCID
140723
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12554654%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 December 2019
Gilles Uzé
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5
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Europe PubMed Central
PMCID
140723
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12554654%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 December 2019
Sandra Pellegrini
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6
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Europe PubMed Central
PMCID
140723
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12554654%20AND%20SRC:MED&resulttype=core&format=json
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17 December 2019
author name string
Josiane Ragimbeau
series ordinal
1
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140723
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17 December 2019
Elisabetta Dondi
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMCID
140723
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12554654%20AND%20SRC:MED&resulttype=core&format=json
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17 December 2019
Pierre Eid
series ordinal
4
1 reference
stated in
Europe PubMed Central
PMCID
140723
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12554654%20AND%20SRC:MED&resulttype=core&format=json
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17 December 2019
language of work or name
English
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publication date
1 February 2003
1 reference
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Europe PubMed Central
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140723
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17 December 2019
published in
The EMBO Journal
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17 December 2019
volume
22
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140723
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17 December 2019
page(s)
537-547
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Europe PubMed Central
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17 December 2019
issue
3
1 reference
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Europe PubMed Central
PMCID
140723
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12554654%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 December 2019
cites work
The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
Structure of the interferon-receptor complex determined by distance constraints from double-mutant cycles and flexible docking
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
Down-modulation of type 1 interferon responses by receptor cross-competition for a shared Jak kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
Interleukin 2 receptors and detergent-resistant membrane domains define a clathrin-independent endocytic pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
Interferons alpha and beta as immune regulators--a new look
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
Involvement of the ubiquitin/proteasome system in sorting of the interleukin 2 receptor beta chain to late endocytic compartments
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
Interleukin-10 and the interleukin-10 receptor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
Partial impairment of cytokine responses in Tyk2-deficient mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta ) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
Stat-1 is not essential for inhibition of B lymphopoiesis by type I IFNs
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
A dual role for the kinase-like domain of the tyrosine kinase Tyk2 in interferon-alpha signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
The function of type I interferons in antimicrobial immunity.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
Jak-Stat signal transduction pathway through the eyes of cytokine class II receptor complexes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
STAT1 affects lymphocyte survival and proliferation partially independent of its role downstream of IFN-gamma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
The type I interferon receptor: structure, function, and evolution of a family business.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
The Janus kinase family of protein tyrosine kinases and their role in signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
A cytosolic domain of the erythropoietin receptor contributes to endoplasmic reticulum-associated degradation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
Identification of a Leu-lle internalization motif within the cytoplasmic domain of the leukaemia inhibitory factor receptor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
Lack of p56lck expression correlates with CD4 endocytosis in primary lymphoid and myeloid cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
How cells respond to interferons
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
Shared receptor components but distinct complexes for alpha and beta interferons
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
The antiviral action of interferon is potentiated by removal of the conserved IRTAM domain of the IFNAR1 chain of the interferon alpha/beta receptor: effects on JAK-STAT activation and receptor down-regulation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
Internalization of the interleukin 6 signal transducer gp130 does not require activation of the Jak/STAT pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
The amino-terminal region of Tyk2 sustains the level of interferon alpha receptor 1, a component of the interferon alpha/beta receptor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
Identification and functional characterization of a second chain of the interleukin-10 receptor complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
An alpha-helical signal in the cytosolic domain of the interleukin 2 receptor beta chain mediates sorting towards degradation after endocytosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
Endocytosis and molecular sorting
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
A negative regulatory region in the intracellular domain of the human interferon-alpha receptor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
Molecular characterization of an alpha interferon receptor 1 subunit (IFNaR1) domain required for TYK2 binding and signal transduction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
Intermediates in degradation of the erythropoietin receptor accumulate and are degraded in lysosomes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
A new member of the cytokine receptor gene family maps on chromosome 21 at less than 35 kb from IFNAR
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
Signal-dependent membrane protein trafficking in the endocytic pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
Endocytosis of the beta chain of interleukin-2 receptor requires neither interleukin-2 nor the gamma chain.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
Functional role of type I and type II interferons in antiviral defense
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
EEA1, an early endosome-associated protein. EEA1 is a conserved alpha-helical peripheral membrane protein flanked by cysteine "fingers" and contains a calmodulin-binding IQ motif
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
Distinct domains of the protein tyrosine kinase tyk2 required for binding of interferon-alpha/beta and for signal transduction.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
The protein tyrosine kinase p56lck inhibits CD4 endocytosis by preventing entry of CD4 into coated pits
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
6 July 2018
Direct signal transduction via functional interferon-alphabeta receptors in CD34+ hematopoietic stem cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
27 October 2018
Novel role of Janus kinase 1 in the regulation of oncostatin M receptor surface expression.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
27 October 2018
Mapping of IFN-beta epitopes important for receptor binding and biologic activation: comparison of results achieved using antibody-based methods and alanine substitution mutagenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
27 October 2018
The receptor interaction region of Tyk2 contains a motif required for its nuclear localization.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
27 October 2018
Surface expression of the IFN-gamma R2 chain is regulated by intracellular trafficking in human T lymphocytes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
27 October 2018
Characterization of Antihuman IFNAR-1 Monoclonal Antibodies: Epitope Localization and Functional Analysis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140723
retrieved
9 December 2018
Cross talk between interferon-gamma and -alpha/beta signaling components in caveolar membrane domains
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/12554654
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Comparison of gene expression patterns induced by treatment of human umbilical vein endothelial cells with IFN-alpha 2b vs. IFN-beta 1a: understanding the functional relationship between distinct type I interferons that act through a common receptor
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/12554654
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Human type I interferon receptor, IFNAR, is a heavily glycosylated 120-130 kD membrane protein
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/12554654
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Characterization of a domain of a human type I interferon receptor protein involved in ligand binding
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/12554654
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Endocytosis and degradation of the growth hormone receptor are proteasome-dependent
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/12554654
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1093/EMBOJ/CDG038
1 reference
stated in
Europe PubMed Central
PMCID
140723
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12554654%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 December 2019
PMCID
140723
1 reference
stated in
Europe PubMed Central
PMCID
140723
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12554654%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 December 2019
PubMed ID
12554654
1 reference
stated in
Europe PubMed Central
PMCID
140723
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12554654%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 December 2019
ResearchGate publication ID
10928020
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