(Q34465092)

2 August 2017

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title

Molecular mechanism of insulin resistance in type 2 diabetes mellitus: role of the insulin receptor variant forms (English)

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2 August 2017

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Sesti G

1

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2 August 2017

Federici M

2

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2 August 2017

Lauro D

3

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2 August 2017

Sbraccia P

4

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2 August 2017

Lauro R

5

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2 August 2017

1 September 2001

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Diabetes - Metabolism: Research and Reviews

2 August 2017

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2 August 2017

17

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2 August 2017

5

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2 August 2017

363-373

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The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus

2 August 2017

1 reference

Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus

21 January 2018

1 reference

Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)

21 January 2018

1 reference

Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)

21 January 2018

1 reference

Mutation in hepatocyte nuclear factor-1 beta gene (TCF2) associated with MODY.

21 January 2018

1 reference

Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence

21 January 2018

1 reference

The insulin signalling system and the IRS proteins

21 January 2018

1 reference

Insulin receptor substrate (IRS) transduction system: distinct and overlapping signaling potential

21 January 2018

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The Gly972-->Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic beta cells

21 January 2018

1 reference

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

21 January 2018

1 reference

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

21 January 2018

1 reference

The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling

21 January 2018

1 reference

Structure of the human insulin receptor gene and characterization of its promoter

21 January 2018

1 reference

Expression and characterization of a 70-kDa fragment of the insulin receptor that binds insulin. Minimizing ligand binding domain of the insulin receptor.

21 January 2018

1 reference

Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786

21 January 2018

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Identification of intron and exon sequences involved in alternative splicing of insulin receptor pre-mRNA.

21 January 2018

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Evidence That Two Naturally Occurring Human Insulin Receptor α-Subunit Variants Are Immunologically Distinct

21 January 2018

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Role of the exon 11 of the insulin receptor gene on insulin binding identified by anti-peptide antibodies

21 January 2018

1 reference

The two isotypes of the human insulin receptor (HIR-A and HIR-B) follow different internalization kinetics

21 January 2018

1 reference

Functional properties of two naturally occurring isoforms of the human insulin receptor in Chinese hamster ovary cells

21 January 2018

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Ligand-binding properties of the two isoforms of the human insulin receptor

21 January 2018

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Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells.

21 January 2018

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Alternative splicing of human insulin receptor messenger RNA.

21 January 2018

1 reference

Tissue-specific expression of two alternatively spliced insulin receptor mRNAs in man.

21 January 2018

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Tissue-specific expression of two alternatively spliced isoforms of the human insulin receptor protein.

21 January 2018

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Regulation of human insulin receptor RNA splicing in vivo

21 January 2018

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Immunological relationships between receptors for insulin and insulin-like growth factor I. Evidence for structural heterogeneity of insulin-like growth factor I receptors involving hybrids with insulin receptors

21 January 2018

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Characterization of human placental insulin-like growth factor-I/insulin hybrid receptors by protein microsequencing and purification

21 January 2018

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Receptors for insulin and insulin-like growth factor-I can form hybrid dimers. Characterisation of hybrid receptors in transfected cells

21 January 2018

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Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity

21 January 2018

1 reference

Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting

21 January 2018

1 reference

Expression of insulin/IGF-I hybrid receptors is increased in skeletal muscle of patients with chronic primary hyperinsulinemia.

21 January 2018

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Evidence for glucose/hexosamine in vivo regulation of insulin/IGF-I hybrid receptor assembly.

21 January 2018

1 reference

Expression and function of insulin/insulin-like growth factor I hybrid receptors during differentiation of 3T3-L1 preadipocytes

21 January 2018

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Altered expression of insulin receptor types A and B in the skeletal muscle of non-insulin-dependent diabetes mellitus patients

21 January 2018

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Insulin receptor isotype expression correlates with risk of non-insulin-dependent diabetes

21 January 2018

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Differences in the ratio of RNA encoding two isoforms of the insulin receptor between control and NIDDM patients. The RNA variant without Exon 11 predominates in both groups.

21 January 2018

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Alternatively spliced variants of the insulin receptor protein. Expression in normal and diabetic human tissues

21 January 2018

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Altered expression of the two naturally occurring human insulin receptor variants in isolated adipocytes of non-insulin-dependent diabetes mellitus patients

21 January 2018

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Altered pattern of insulin receptor isotypes in skeletal muscle membranes of type 2 (non-insulin-dependent) diabetic subjects

21 January 2018

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Chronic primary hyperinsulinaemia is associated with altered insulin receptor mRNA splicing in muscle of patients with insulinoma

21 January 2018

1 reference

Increased expression of insulin/insulin-like growth factor-I hybrid receptors in skeletal muscle of noninsulin-dependent diabetes mellitus subjects

21 January 2018

1 reference

Insulin/insulin-like growth factor I hybrid receptors overexpression is not an early defect in insulin-resistant subjects.

21 January 2018

1 reference

A 973 valine to methionine mutation of the human insulin receptor: interaction with insulin-receptor substrate-1 and Shc in HEK 293 cells

21 January 2018

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The amino acid sequence of the insulin receptor is normal in an insulin-resistant Pima Indian

21 January 2018

1 reference

Analysis of the gene sequences of the insulin receptor and the insulin-sensitive glucose transporter (GLUT-4) in patients with common-type non-insulin-dependent diabetes mellitus

21 January 2018

1 reference

Insulin receptor and insulin-responsive glucose transporter (GLUT 4) mutations and polymorphisms in a Welsh type 2 (non-insulin-dependent) diabetic population

21 January 2018

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The Val985Met insulin-receptor variant in the Danish Caucasian population: lack of associations with non-insulin-dependent diabetes mellitus or insulin resistance

21 January 2018

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Frequency of mutations of insulin receptor gene in Japanese patients with NIDDM.

21 January 2018

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NIDDM Associated With Mutation in Tyrosine Kinase Domain of Insulin Receptor Gene

21 January 2018

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The common Arg972 polymorphism in insulin receptor substrate-1 causes apoptosis of human pancreatic islets

21 January 2018

1 reference

7 January 2021

Molecular recognition of human insulin receptor by autoantibodies in a human serum

1 reference

7 January 2021

Different ligand affinities of the two human insulin receptor splice variants are reflected in parallel changes in sensitivity for insulin action

1 reference

7 January 2021

Insulin receptor activation by IGF-II in breast cancers: evidence for a new autocrine/paracrine mechanism

1 reference

7 January 2021

Regulation of human insulin receptor RNA splicing in HepG2 cells: effects of glucocorticoid and low glucose concentration

1 reference

7 January 2021

Distribution of insulin/insulin-like growth factor-I hybrid receptors in human tissues

1 reference

7 January 2021

Increased abundance of insulin/IGF-I hybrid receptors in adipose tissue from NIDDM patients

1 reference

7 January 2021

Increased expression of low-affinity insulin receptor isoform and insulin/insulin-like growth factor-I hybrid receptors in term placenta from insulin-resistant women with gestational hypertension

1 reference

7 January 2021

Normal insulin-receptor cDNA sequence in Pima Indians with NIDDM

1 reference

7 January 2021

Detection of mutations in insulin-receptor gene in NIDDM patients by analysis of single-stranded conformation polymorphisms

1 reference

7 January 2021

Recombinant human insulin-like growth factor I increases insulin sensitivity and improves glycemic control in type II diabetes

1 reference

7 January 2021

Identifiers

DOI

10.1002/DMRR.225

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2 August 2017

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