(Q54104864)

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Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

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Europe PubMed Central

PubMed publication ID

24 May 2018

http://europepmc.org/abstract/MED/10025399

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. (English)

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Europe PubMed Central

PubMed publication ID

24 May 2018

http://europepmc.org/abstract/MED/10025399

type 2 diabetes

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Catherine Postic

4

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Europe PubMed Central

PubMed publication ID

24 May 2018

http://europepmc.org/abstract/MED/10025399

5

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Europe PubMed Central

PubMed publication ID

24 May 2018

http://europepmc.org/abstract/MED/10025399

6

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Kahn CR

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Europe PubMed Central

PubMed publication ID

24 May 2018

author name string

Kulkarni RN

1

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Europe PubMed Central

PubMed publication ID

24 May 2018

http://europepmc.org/abstract/MED/10025399

Brüning JC

2

1 reference

Europe PubMed Central

PubMed publication ID

24 May 2018

http://europepmc.org/abstract/MED/10025399

Winnay JN

3

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Europe PubMed Central

PubMed publication ID

24 May 2018

http://europepmc.org/abstract/MED/10025399

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1 February 1999

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Europe PubMed Central

PubMed publication ID

24 May 2018

http://europepmc.org/abstract/MED/10025399

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Europe PubMed Central

PubMed publication ID

24 May 2018

http://europepmc.org/abstract/MED/10025399

96

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Europe PubMed Central

PubMed publication ID

24 May 2018

http://europepmc.org/abstract/MED/10025399

3

1 reference

Europe PubMed Central

PubMed publication ID

24 May 2018

http://europepmc.org/abstract/MED/10025399

329-339

1 reference

Europe PubMed Central

PubMed publication ID

24 May 2018

http://europepmc.org/abstract/MED/10025399

Early neonatal death in mice homozygous for a null allele of the insulin receptor gene

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

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Indirect evidence for short-loop negative feedback of insulin secretion in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

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Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Insulin suppresses its own secretion in vivo

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Relationships between insulin secretion, insulin action, and fasting plasma glucose concentration in nondiabetic and noninsulin-dependent diabetic subjects

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

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Compensatory Growth of Pancreatic -Cells in Adult Rats After Short-Term Glucose Infusion

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

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Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

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A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

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Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Decreased Sensitivity of the Pancreatic Beta Cells to Glucose in Prediabetic and Diabetic Subjects: A Glucose Dose-Response Study

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

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Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Low insulin response: a marker of prediabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Feedback inhibition of insulin secretion by insulin: relation to the hyperinsulinemia of obesity

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Maturity-onset diabetes of the young (MODY).

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Antibodies That Impair Insulin Receptor Binding in an Unusual Diabetic Syndrome with Severe Insulin Resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

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The evolution of function and response to arginine challenge and pregnancy of portally and systemically placed islet cell grafts in streptozotocin diabetic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

The pathogenesis of NIDDM.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of insulin receptor mRNA and insulin receptor substrate 1 in pancreatic islet beta-cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Evidence for a Feedback Inhibition of Insulin on Insulin Secretion in the Isolated, Perfused Canine Pancreas

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Heterogeneous expression of glucokinase among pancreatic beta cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Fluorescence-activated cell sorted rat islet cells and studies of the insulin secretory process

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Inducible gene targeting in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Insulin-like growth factor-I at physiological concentrations is a potent inhibitor of insulin secretion

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Beta-cell dysfunction induced by chronic hyperglycemia. Current ideas on mechanism of impaired glucose-induced insulin secretion

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

A role for endogenous prostaglandins in defective glucose potentiation of nonglucose insulin secretagogues in diabetics

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Insulin deficiency and insulin resistance in type 2 (non-insulin-dependent) diabetes: quantitative contributions of pancreatic and peripheral responses to glucose homeostasis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Insulin resistance and non-insulin-dependent diabetes mellitus: cellular and molecular mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Lack of control by glucose of ultradian insulin secretory oscillations in impaired glucose tolerance and in non-insulin-dependent diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Quantitative Electron Microscopic Autoradiography of Insulin, Glucagon, and Somatostatin Binding Sites on Islets

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Insulin responses to nonglucose stimuli in non-insulin-dependent diabetes mellitus during a tolbutamide infusion

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

An integrated view of beta-cell dysfunction in type-II diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Lilly Lecture 1994. The beta-cell in diabetes: from molecular genetics to clinical research

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Banting lecture 1990. Beta-cells in type II diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Banting lecture 1988. Role of insulin resistance in human disease

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Glucose-induced insulin receptor tyrosine phosphorylation in insulin-secreting beta-cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Lilly Lecture: molecular mechanisms of insulin resistance. Lessons from patients with mutations in the insulin-receptor gene

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

INSULIN DEFICIENCY IN NON-INSULIN-DEPENDENT DIABETES

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

The loss of GLUT2 expression by glucose-unresponsive beta cells of db/db mice is reversible and is induced by the diabetic environment

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Abnormal Islet and Adipocyte Function in Young B-cell-deficient Rats with Near-Normoglycemia

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Subregion- and cell type-restricted gene knockout in mouse brain

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Pathogenesis of NIDDM--a disease of deficient insulin secretion

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Diabetic hyperglycemia: link to impaired glucose transport in pancreatic beta cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

The defective glucose sensitivity of the B cell in non insulin dependent diabetes. Improvement after twenty hours of normoglycaemia

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Pancreatic hormone receptors on islet cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Evidence for the presence of type I insulin-like growth factor receptors on rat pancreatic A and B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Evidence for presence of insulin receptors in rat islets of Langerhans

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanisms of arginine-induced increase in cytosolic calcium concentration in the beta-cell line NIT-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Disruption of IRS-2 causes type 2 diabetes in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0092-8674(00)80546-2

1 reference

Europe PubMed Central

PubMed publication ID

24 May 2018

http://europepmc.org/abstract/MED/10025399

release_7rtu5ynvujgdfiqudfugm5rgea

1 reference

https://api.fatcat.wiki/v0/release/7rtu5ynvujgdfiqudfugm5rgea

24 November 2022

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

24 May 2018

http://europepmc.org/abstract/MED/10025399

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