(Q34471813)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202140%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

title

Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202140%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202140%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

Philip J Lupo

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202140%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

Kenneth L McClain

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202140%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

21

Miriam Merad

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202140%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

11

Donna M Muzny

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202140%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

author name string

Rikhia Chakraborty

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202140%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

Oliver A Hampton

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202140%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

Xiaoyun Shen

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202140%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

Stephen J Simko

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202140%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

Albert Shih

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202140%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

Harshal Abhyankar

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202140%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

Karen Phaik Har Lim

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202140%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

Kyle R Covington

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202140%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

Lisa Trevino

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202140%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

Ninad Dewal

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202140%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

Harshavardhan Doddapaneni

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202140%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

Jianhong Hu

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202140%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

M John Hicks

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202140%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

Diana L Bonilla

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202140%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

Karen C Dwyer

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202140%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

Marie-Luise Berres

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202140%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

Poulikos I Poulikakos

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202140%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

David A Wheeler

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202140%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

Carl E Allen

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202140%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

D Williams Parsons

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202140%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

language of work or name

English

0 references

publication date

8 September 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202140%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202140%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

volume

124

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202140%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

issue

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202140%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

page(s)

3007-3015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202140%20AND%20SRC:MED&resulttype=core&format=json

Somatic activating ARAF mutations in Langerhans cell histiocytosis.

16 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224195

BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224195

Launching genomics into the cloud: deployment of Mercury, a next generation sequence analysis pipeline

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224195

Genomic sequencing for cancer diagnosis and therapy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224195

High prevalence of MAP2K1 mutations in variant and IGHV4-34-expressing hairy-cell leukemias

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224195

Pathological consequence of misguided dendritic cell differentiation in histiocytic diseases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224195

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224195

Oncogenic ERBB3 mutations in human cancers

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224195

Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224195

A landscape of driver mutations in melanoma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224195

MEK genomics in development and disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224195

B-RAF mutant alleles associated with Langerhans cell histiocytosis, a granulomatous pediatric disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224195

Combinations of BRAF, MEK, and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib, mediated by NRAS or MEK mutations

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224195

Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224195

High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224195

Targeted enrichment beyond the consensus coding DNA sequence exome reveals exons with higher variant densities

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224195

Benchmarking of mutation diagnostics in clinical lung cancer specimens

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224195

Resistance to MEK inhibitors: should we co-target upstream?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224195

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224195

Recurrent BRAF mutations in Langerhans cell histiocytosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224195

Cell-specific gene expression in Langerhans cell histiocytosis lesions reveals a distinct profile compared with epidermal Langerhans cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224195

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224195

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224195

Juvenile myelomonocytic leukemia: a report from the 2nd International JMML Symposium

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224195

Mutational analysis of the ARAF gene in human cancers.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224195

Mutations of the BRAF gene in human cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224195

Rhabdomyosarcoma in a patient with cardio-facio-cutaneous syndrome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224195

The histiocytoses: the fall of the Tower of Babel

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224195

PICK1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224195

Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224195

Detection of an NRAS mutation in Erdheim-Chester disease.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224195

Therapy prolongation improves outcome in multisystem Langerhans cell histiocytosis.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224195

Identification of the V600D mutation in Exon 15 of the BRAF oncogene in congenital, benign langerhans cell histiocytosis.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224195

High prevalence of BRAF V600E mutations in Erdheim-Chester disease but not in other non-Langerhans cell histiocytoses.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224195

BRAFV600E mutant protein is expressed in cells of variable maturation in Langerhans cell histiocytosis.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224195

Mutation and phenotypic spectrum in patients with cardio-facio-cutaneous and Costello syndrome.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224195

Hepatoblastoma and heart transplantation in a patient with cardio-facio-cutaneous syndrome

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224195

Leukemia in Cardio-facio-cutaneous (CFC) syndrome: a patient with a germline mutation in BRAF proto-oncogene.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224195

Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224195

Sensitive mutation detection in heterogeneous cancer specimens by massively parallel picoliter reactor sequencing

27 October 2018

1 reference

12 December 2020

No genomic aberrations in Langerhans cell histiocytosis as assessed by diverse molecular technologies

1 reference

12 December 2020

AnNRASmutation in a case of Erdheim-Chester disease

1 reference

12 December 2020

A phase IIa study of afuresertib, an oral pan-AKT inhibitor, in patients with Langerhans cell histiocytosis.

1 reference

12 December 2020

10.1182/BLOOD-2014-05-577825

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202140%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202140%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

PubMed publication ID

25202140

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202140%20AND%20SRC:MED&resulttype=core&format=json