(Q34477471)

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HIV-1 tat promotes integrin-mediated HIV transmission to dendritic cells by binding Env spikes and competes neutralization by anti-HIV antibodies

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2 August 2017

HIV-1 tat promotes integrin-mediated HIV transmission to dendritic cells by binding Env spikes and competes neutralization by anti-HIV antibodies (English)

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2 August 2017

HIV transmission

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Indresh K Srivastava

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Sonia Moretti

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Victoria A Sharma

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Maria R Pavone Cossut

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Alessandra Borsetti

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Maria T Maggiorella

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Jeffrey B Ulmer

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Stefano Buttò

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Maurizio P M Federico

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Fausto Titti

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Franco Dallocchio

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13 November 2012

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Creative Commons Attribution 4.0 International

13 November 2012

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April 2022 Public Data File from Crossref

copyright status

0 references

Immune-correlates analysis of an HIV-1 vaccine efficacy trial

1 reference

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Therapeutic immunization with HIV-1 Tat reduces immune activation and loss of regulatory T-cells and improves immune function in subjects on HAART

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Impact of viral dose and major histocompatibility complex class IB haplotype on viral outcome in mauritian cynomolgus monkeys vaccinated with Tat upon challenge with simian/human immunodeficiency virus SHIV89.6P

1 reference

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Phosphatidylinositol-(4,5)-bisphosphate enables efficient secretion of HIV-1 Tat by infected T-cells

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Targeting early infection to prevent HIV-1 mucosal transmission.

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Innovative approaches to develop prophylactic and therapeutic vaccines against HIV/AIDS.

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The preventive phase I trial with the HIV-1 Tat-based vaccine

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Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand

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6 July 2018

A replication-competent adenovirus-human immunodeficiency virus (Ad-HIV) tat and Ad-HIV env priming/Tat and envelope protein boosting regimen elicits enhanced protective efficacy against simian/human immunodeficiency virus SHIV89.6P challenge in rhe

1 reference

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Generation and characterization of a stable cell population releasing fluorescent HIV-1-based Virus Like Particles in an inducible way.

1 reference

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Human immunodeficiency virus type 1 V1-V2 envelope loop sequences expand and add glycosylation sites over the course of infection, and these modifications affect antibody neutralization sensitivity

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Immune cell migration in inflammation: present and future therapeutic targets

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Structure of a V3-containing HIV-1 gp120 core

1 reference

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The Amber biomolecular simulation programs

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The V1, V2, and V3 regions of the human immunodeficiency virus type 1 envelope differentially affect the viral phenotype in an isolate-dependent manner

1 reference

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Selection for human immunodeficiency virus type 1 envelope glycosylation variants with shorter V1-V2 loop sequences occurs during transmission of certain genetic subtypes and may impact viral RNA levels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496724

6 July 2018

Structure of an unliganded simian immunodeficiency virus gp120 core

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496724

6 July 2018

Cell surface-associated Tat modulates HIV-1 infection and spreading through a specific interaction with gp120 viral envelope protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496724

6 July 2018

Integrins and angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496724

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Nonstructural HIV proteins as targets for prophylactic or therapeutic vaccines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496724

6 July 2018

HIV-1 tat protein modulates the generation of cytotoxic T cell epitopes by modifying proteasome composition and enzymatic activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496724

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ClusPro: a fully automated algorithm for protein-protein docking

1 reference

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Purification, Characterization, and Immunogenicity of a Soluble Trimeric Envelope Protein Containing a Partial Deletion of the V2 Loop Derived from SF162, an R5-Tropic Human Immunodeficiency Virus Type 1 Isolate

1 reference

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HADDOCK: a protein-protein docking approach based on biochemical or biophysical information

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496724

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Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496724

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Homonuclear (1)H-NMR assignment and structural characterization of human immunodeficiency virus type 1 Tat Mal protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496724

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Inflammation, immune reactivity, and angiogenesis in a severe combined immunodeficiency model of rheumatoid arthritis

1 reference

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Native HIV-1 Tat protein targets monocyte-derived dendritic cells and enhances their maturation, function, and antigen-specific T cell responses

1 reference

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The ability of an oligomeric human immunodeficiency virus type 1 (HIV-1) envelope antigen to elicit neutralizing antibodies against primary HIV-1 isolates is improved following partial deletion of the second hypervariable region

1 reference

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Efficient gene transduction by RGD-fiber modified recombinant adenovirus into dendritic cells

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Mucosal vaccines: non toxic derivatives of LT and CT as mucosal adjuvants.

1 reference

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1H-13C nuclear magnetic resonance assignment and structural characterization of HIV-1 Tat protein

1 reference

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Maturation-dependent expression and function of the CD49d integrin on monocyte-derived human dendritic cells

1 reference

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Selective CXCR4 antagonism by Tat: implications for in vivo expansion of coreceptor use by HIV-1

1 reference

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Comparative analysis of integrin expression on monocyte-derived macrophages and monocyte-derived dendritic cells.

1 reference

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Inflammatory cytokines synergize with the HIV-1 Tat protein to promote angiogenesis and Kaposi's sarcoma via induction of basic fibroblast growth factor and the alpha v beta 3 integrin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496724

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Tat protein induces human immunodeficiency virus type 1 (HIV-1) coreceptors and promotes infection with both macrophage-tropic and T-lymphotropic HIV-1 strains

1 reference

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High-titer human immunodeficiency virus type 1-based vector systems for gene delivery into nondividing cells.

1 reference

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A third-generation lentivirus vector with a conditional packaging system

1 reference

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1 reference

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1 reference

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HIV-1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix-associated heparan sulfate proteoglycans through its basic region

1 reference

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Release, uptake, and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation

1 reference

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6 July 2018

Comparative protein modelling by satisfaction of spatial restraints

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496724

6 July 2018

Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496724

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The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence

1 reference

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A novel integrin specificity exemplified by binding of the alpha v beta 5 integrin to the basic domain of the HIV Tat protein and vitronectin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496724

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Involvement of the V1/V2 variable loop structure in the exposure of human immunodeficiency virus type 1 gp120 epitopes induced by receptor binding

1 reference

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Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120.

1 reference

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1 reference

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1 reference

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SHIV89.6P pathogenicity in cynomolgus monkeys and control of viral replication and disease onset by human immunodeficiency virus type 1 Tat vaccine.

1 reference

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Vaccination with DNA containing tat coding sequences and unmethylated CpG motifs protects cynomolgus monkeys upon infection with simian/human immunodeficiency virus (SHIV89.6P).

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0048781

21 January 2018

Long-term protection against SHIV89.6P replication in HIV-1 Tat vaccinated cynomolgus monkeys.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0048781

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1 reference

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Phase I therapeutic trial of the HIV-1 Tat protein and long term follow-up.

1 reference

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21 January 2018

HIV-1 Tat addresses dendritic cells to induce a predominant Th1-type adaptive immune response that appears prevalent in the asymptomatic stage of infection

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0048781

21 January 2018

Immobilized HIV-1 Tat protein promotes gene transfer via a transactivation-independent mechanism which requires binding of Tat to viral particles

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0048781

21 January 2018

Antibodies against full-length Tat protein and some low-molecular-weight Tat-peptides correlate with low or undetectable viral load in HIV-1 seropositive patients

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0048781

21 January 2018

The presence of anti-Tat antibodies is predictive of long-term nonprogression to AIDS or severe immunodeficiency: findings in a cohort of HIV-1 seroconverters

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0048781

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A combination HIV vaccine based on Tat and Env proteins was immunogenic and protected macaques from mucosal SHIV challenge in a pilot study.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0048781

21 January 2018

Inhibition of HIV-1 replication by a Tat transdominant negative mutant in human peripheral blood lymphocytes from healthy donors and HIV-1-infected patients

1 reference

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21 January 2018

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The modulation of dendritic cell integrin binding and activation by RGD-peptide density gradient substrates

1 reference

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Envelope-constrained neutralization-sensitive HIV-1 after heterosexual transmission

1 reference

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21 January 2018

Innate anti-viral immunity is associated with the protection elicited by the simian immunodeficiency virus (SIV) live attenuated virus vaccine in cynomolgus monkeys.

1 reference

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27 October 2018

BiGGER: a new (soft) docking algorithm for predicting protein interactions.

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27 October 2018

The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha5beta1 and alphavbeta3 integrins and by mobilizing sequestered basic fibroblast growth factor.

1 reference

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27 October 2018

The therapeutic phase I trial of the recombinant native HIV-1 Tat protein

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0048781

21 January 2018

Monocyte-derived dendritic cells and monocytes migrate to HIV-Tat RGD and basic peptides

1 reference

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21 January 2018

Vaccines based on the native HIV Tat protein and on the combination of Tat and the structural HIV protein variant ΔV2 Env

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https://pubmed.ncbi.nlm.nih.gov/23152803

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inferred from PubMed ID database lookup

Targeting of angiogenic endothelial cells at sites of inflammation by dexamethasone phosphate–containing RGD peptide liposomes inhibits experimental arthritis

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https://pubmed.ncbi.nlm.nih.gov/23152803

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inferred from PubMed ID database lookup

Candidate HIV-1 Tat vaccine development: from basic science to clinical trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/23152803

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based on heuristic

inferred from PubMed ID database lookup

The Tat protein broadens T cell responses directed to the HIV-1 antigens Gag and Env: Implications for the design of new vaccination strategies against AIDS

1 reference

https://pubmed.ncbi.nlm.nih.gov/23152803

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based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/23152803

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibodies to Tat and Vpr in the GRIV cohort: differential association with maintenance of long-term non-progression status in HIV-1 infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/23152803

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of retroviral vectors for the analysis of SIV/HIV-specific CD8 T cell responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/23152803

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contribution of antibody response to recombinant HIV-1 gene-encoded products nef, rev, tat, and protease in predicting development of AIDS in HIV-1-infected individuals

1 reference

https://pubmed.ncbi.nlm.nih.gov/23152803

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human blood dendritic cells: binding to vascular endothelium and expression of adhesion molecules

1 reference

https://pubmed.ncbi.nlm.nih.gov/23152803

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibodies to the HIV-1 Tat protein correlated with nonprogression to AIDS: a rationale for the use of Tat toxoid as an HIV-1 vaccine

1 reference

https://pubmed.ncbi.nlm.nih.gov/23152803

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of SHIV-89.6P-infection of cynomolgus monkeys by HIV-1 Tat protein vaccine

1 reference

https://pubmed.ncbi.nlm.nih.gov/23152803

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0048781

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

2012PLoSO...748781M

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

ResearchGate publication ID

0 references

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