(Q34480682)

2 August 2017

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title

Molecular biology of Hodgkin's and Reed/Sternberg cells in Hodgkin's lymphoma (English)

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2 August 2017

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6

Ralf Küppers

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Martin-Leo Hansmann

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object named as

Martin-Leo Hansmann

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author name string

Andreas Bräuninger

1

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2 August 2017

Roland Schmitz

2

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2 August 2017

Dörte Bechtel

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2 August 2017

Christoph Renné

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2 August 2017

language of work or name

English

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publication date

1 April 2006

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International Journal of Cancer

2 August 2017

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2 August 2017

118

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2 August 2017

1853-1861

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2 August 2017

8

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Hodgkin and Reed-Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal center-derived tumor B cells

2 August 2017

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Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells.

21 January 2018

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Origin of nodular lymphocyte-predominant Hodgkin's disease from a clonal expansion of highly mutated germinal-center B cells.

21 January 2018

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Clonal selection and learning in the antibody system

21 January 2018

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Rare occurrence of classical Hodgkin's disease as a T cell lymphoma

21 January 2018

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Loss of the B-lineage-specific gene expression program in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma

21 January 2018

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Classical Hodgkin lymphoma is characterized by recurrent copy number gains of the short arm of chromosome 2.

21 January 2018

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Recurrent involvement of the REL and BCL11A loci in classical Hodgkin lymphoma.

21 January 2018

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Mutations in the IkBa gene in Hodgkin's disease suggest a tumour suppressor role for IkappaBalpha.

21 January 2018

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Inactivating I kappa B epsilon mutations in Hodgkin/Reed-Sternberg cells

21 January 2018

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Clonal deleterious mutations in the IkappaBalpha gene in the malignant cells in Hodgkin's lymphoma

21 January 2018

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Measles virus: evidence of an association with Hodgkin's disease.

21 January 2018

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Virus target cell conditioning model to explain some epidemiologic characteristics of childhood leukemias and lymphomas

21 January 2018

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Notch regulation of lymphocyte development and function.

21 January 2018

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Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma.

21 January 2018

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Autocrine- and paracrine-activated receptor tyrosine kinases in classic Hodgkin lymphoma

21 January 2018

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Expression of the c-met proto-oncogene and its ligand, hepatocyte growth factor, in Hodgkin disease

21 January 2018

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Constitutive activation of phosphatidyl-inositide 3 kinase contributes to the survival of Hodgkin's lymphoma cells through a mechanism involving Akt kinase and mTOR.

21 January 2018

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MEK/ERK pathway is aberrantly active in Hodgkin disease: a signaling pathway shared by CD30, CD40, and RANK that regulates cell proliferation and survival

21 January 2018

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The two NF-kappaB activation pathways and their role in innate and adaptive immunity

21 January 2018

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Functional expression of receptor activator of nuclear factor kappaB in Hodgkin disease cell lines.

21 January 2018

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Ligand-independent signaling by overexpressed CD30 drives NF-kappaB activation in Hodgkin-Reed-Sternberg cells

21 January 2018

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Epstein-Barr virus-mediated B-cell proliferation is dependent upon latent membrane protein 1, which simulates an activated CD40 receptor

21 January 2018

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Nuclear factor kappaB-dependent gene expression profiling of Hodgkin's disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity

21 January 2018

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STAT3 is constitutively activated in Hodgkin cell lines

21 January 2018

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The Stat family in cytokine signaling

21 January 2018

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Stats: transcriptional control and biological impact

21 January 2018

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STAT3 is essential for Hodgkin lymphoma cell proliferation and is a target of tyrphostin AG17 which confers sensitization for apoptosis

21 January 2018

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Interleukin 13 is secreted by and stimulates the growth of Hodgkin and Reed-Sternberg cells

21 January 2018

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Interleukin 13 and interleukin 13 receptor are frequently expressed by Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma

21 January 2018

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AP-1 as a regulator of cell life and death

21 January 2018

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Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B.

21 January 2018

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Cell signaling by receptor tyrosine kinases

21 January 2018

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Inhibition of NF-kappaB essentially contributes to arsenic-induced apoptosis.

21 January 2018

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Fas-induced apoptosis in B cells

21 January 2018

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Cultivated H-RS cells are resistant to CD95L-mediated apoptosis despite expression of wild-type CD95.

21 January 2018

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Expression of the cellular FLICE-inhibitory protein (c-FLIP) protects Hodgkin's lymphoma cells from autonomous Fas-mediated death

21 January 2018

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c-FLIP mediates resistance of Hodgkin/Reed-Sternberg cells to death receptor-induced apoptosis

21 January 2018

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XIAP-mediated caspase inhibition in Hodgkin's lymphoma-derived B cells

21 January 2018

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NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling

21 January 2018

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Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells.

21 January 2018

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Identification of common germinal-center B-cell precursors in two patients with both Hodgkin's disease and non-Hodgkin's lymphoma

21 January 2018

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21 January 2018

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Indications for peripheral light-chain revision and somatic hypermutation without a functional B-cell receptor in precursors of a composite diffuse large B-cell and Hodgkin's lymphoma

21 January 2018

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Classical Hodgkin's disease and follicular lymphoma originating from the same germinal center B cell

21 January 2018

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Immunoglobulin gene rearrangement analysis in composite hodgkin disease and large B-cell lymphoma: evidence for receptor revision of immunoglobulin heavy chain variable region genes in Hodgkin-Reed-Sternberg cells?

21 January 2018

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Epstein-Barr virus-negative Hodgkin's lymphoma after mycosis fungoides: molecular evidence for distinct clonal origin.

21 January 2018

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Cellular origin of human B-cell lymphomas.

21 January 2018

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Down-regulation of BOB.1/OBF.1 and Oct2 in classical Hodgkin disease but not in lymphocyte predominant Hodgkin disease correlates with immunoglobulin transcription

21 January 2018

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Molecular mimicry of the antigen receptor signalling motif by transmembrane proteins of the Epstein-Barr virus and the bovine leukaemia virus.

21 January 2018

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Epstein-Barr virus LMP2A drives B cell development and survival in the absence of normal B cell receptor signals

21 January 2018

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B cell receptor signal strength determines B cell fate.

21 January 2018

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Epstein-Barr virus (EBV)-positive lymphoproliferations in post-transplant patients show immunoglobulin V gene mutation patterns suggesting interference of EBV with normal B cell differentiation processes

21 January 2018

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An unbalanced translocation involving chromosome 14 is the probable cause for loss of potentially functional rearranged immunoglobulin heavy chain genes in the Epstein-Barr virus-positive Hodgkin's lymphoma-derived cell line L591.

21 January 2018

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Survival of resting mature B lymphocytes depends on BCR signaling via the Igalpha/beta heterodimer.

21 January 2018

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In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death.

21 January 2018

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Transformation of BCR-deficient germinal-center B cells by EBV supports a major role of the virus in the pathogenesis of Hodgkin and posttransplantation lymphomas

21 January 2018

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Epstein-Barr virus infection in vitro can rescue germinal center B cells with inactivated immunoglobulin genes

21 January 2018

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Rescue of "crippled" germinal center B cells from apoptosis by Epstein-Barr virus

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IJC.21716

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2 August 2017

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