(Q34490707)

2 August 2017

title

Disease allele-dependent small-molecule sensitivities in blood cells from monogenic diabetes (English)

1 reference

2 August 2017

7

Stuart L Schreiber

1 reference

2 August 2017

Stanley Y Shaw

1

1 reference

2 August 2017

David M Blodgett

2

1 reference

2 August 2017

Maggie S Ma

3

1 reference

2 August 2017

Elizabeth C Westly

4

1 reference

2 August 2017

Paul A Clemons

5

1 reference

2 August 2017

Aravind Subramanian

6

1 reference

2 August 2017

language of work or name

English

0 references

publication date

23 December 2010

1 reference

Proceedings of the National Academy of Sciences of the United States of America

2 August 2017

published in

1 reference

2 August 2017

volume

108

1 reference

2 August 2017

issue

2

1 reference

2 August 2017

page(s)

492-497

1 reference

Integrated approach for the identification of human hepatocyte nuclear factor 4alpha target genes using protein binding microarrays

2 August 2017

cites work

1 reference

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Hyperinsulinism and diabetes: genetic dissection of beta cell metabolism-excitation coupling in mice

6 July 2018

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Identifying druggable disease-modifying gene products

6 July 2018

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Systematic mapping of genetic interaction networks

6 July 2018

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Identification of an endogenous ligand bound to a native orphan nuclear receptor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021060

Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021060

Monogenic diabetes in the young, pharmacogenetics and relevance to multifactorial forms of type 2 diabetes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021060

Dexamethasone-mediated up-regulation of human CYP2A6 involves the glucocorticoid receptor and increased binding of hepatic nuclear factor 4 alpha to the proximal promoter

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021060

ChemBank: a small-molecule screening and cheminformatics resource database

6 July 2018

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Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma

6 July 2018

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Mapping genes that contribute to daunorubicin-induced cytotoxicity

6 July 2018

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Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021060

A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021060

6 July 2018

1 reference

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Amiloride derivatives enhance insulin release in pancreatic islets from diabetic mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021060

Mapping determinants of human gene expression by regional and genome-wide association

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021060

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021060

The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021060

Genome-wide discovery of loci influencing chemotherapy cytotoxicity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021060

Heritability and linkage analysis of sensitivity to cisplatin-induced cytotoxicity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021060

Control of pancreas and liver gene expression by HNF transcription factors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021060

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021060

Molecular site of action of the antiarrhythmic drug propafenone at the voltage-operated potassium channel Kv2.1.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021060

Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021060

Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021060

Prediction of central nervous system embryonal tumour outcome based on gene expression

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021060

Hyperinsulinism/hyperammonemia syndrome in children with regulatory mutations in the inhibitory guanosine triphosphate-binding domain of glutamate dehydrogenase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021060

Propafenone blocks ATP-sensitive K+ channels in rabbit atrial and ventricular cardiomyocytes.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021060

The maturity-onset diabetes of the young (MODY1) transcription factor HNF4alpha regulates expression of genes required for glucose transport and metabolism

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021060

Loss of protein kinase C inhibition in the beta-T594M variant of the amiloride-sensitive Na+ channel

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021060

Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021060

Altered insulin secretory responses to glucose in subjects with a mutation in the MODY1 gene on chromosome 20.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021060

Scope and heterogeneous nature of MODY.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021060

Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways

6 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1016789108

Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1016789108

MODY1 mutation Q268X in hepatocyte nuclear factor 4alpha allows for dimerization in solution but causes abnormal subcellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1016789108

Abnormal insulin secretion, not insulin resistance, is the genetic or primary defect of MODY in the RW pedigree.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1016789108

HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1016789108

Comparative gene marker selection suite

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1016789108

Dimethyl amiloride improves glucose homeostasis in mouse models of type 2 diabetes

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021060

Propafenone modulates potassium channel activities of vascular smooth muscle from rat portal veins.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021060

27 October 2018

Identifiers

DOI

10.1073/PNAS.1016789108

1 reference

2 August 2017

0 references

1 reference

2 August 2017

1 reference