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Pathomechanisms underlying X-adrenoleukodystrophy: a three-hit hypothesis.
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scholarly article
1 reference
stated in
Europe PubMed Central
PMC publication ID
3021280
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20626745%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 February 2020
review article
1 reference
stated in
Europe PubMed Central
title
Pathomechanisms underlying X-adrenoleukodystrophy: a three-hit hypothesis
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
3021280
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20626745%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 February 2020
author
Aurora Pujol
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
3021280
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20626745%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 February 2020
author name string
Inderjit Singh
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
3021280
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20626745%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 February 2020
publication date
1 July 2010
1 reference
stated in
Europe PubMed Central
PMC publication ID
3021280
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20626745%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 February 2020
published in
Brain Pathology
1 reference
stated in
Europe PubMed Central
PMC publication ID
3021280
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20626745%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 February 2020
volume
20
1 reference
stated in
Europe PubMed Central
PMC publication ID
3021280
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20626745%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 February 2020
issue
4
1 reference
stated in
Europe PubMed Central
PMC publication ID
3021280
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20626745%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 February 2020
page(s)
838-844
1 reference
stated in
Europe PubMed Central
PMC publication ID
3021280
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20626745%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 February 2020
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Very long-chain fatty acid accumulation causes lipotoxic response via 5-lipoxygenase in cerebral adrenoleukodystrophy
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Oxidative stress induced by loss of Cu,Zn-superoxide dismutase (SOD1) or superoxide-generating herbicides causes axonal degeneration in mouse DRG cultures
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ABCD2 is abundant in adipose tissue and opposes the accumulation of dietary erucic acid (C22:1) in fat
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Newborn screening for X-linked adrenoleukodystrophy (X-ALD): validation of a combined liquid chromatography-tandem mass spectrometric (LC-MS/MS) method
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Oxidative imbalance in nonstimulated X-adrenoleukodystrophy-derived lymphoblasts
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6 July 2018
Enhanced production of nitric oxide, reactive oxygen species, and pro-inflammatory cytokines in very long chain saturated fatty acid-accumulated macrophages
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PMP70 knock-down generates oxidative stress and pro-inflammatory cytokine production in C6 glial cells
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6 July 2018
A key role for the peroxisomal ABCD2 transporter in fatty acid homeostasis.
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6 July 2018
The human peroxisomal ABC half transporter ALDP functions as a homodimer and accepts acyl-CoA esters
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6 July 2018
Silencing of Abcd1 and Abcd2 genes sensitizes astrocytes for inflammation: implication for X-adrenoleukodystrophy
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6 July 2018
Plasmalogen deficiency in cerebral adrenoleukodystrophy and its modulation by lovastatin
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6 July 2018
Nmnat delays axonal degeneration caused by mitochondrial and oxidative stress
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6 July 2018
Reversal of axonal loss and disability in a mouse model of progressive multiple sclerosis.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
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6 July 2018
Lipopolysaccharide-induced peroxisomal dysfunction exacerbates cerebral white matter injury: attenuation by N-acetyl cysteine
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
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6 July 2018
Biochemistry of mammalian peroxisomes revisited
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
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6 July 2018
X-linked adrenoleukodystrophy enigma: how does the ALD peroxisomal transporter mutation affect CNS glia?
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
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6 July 2018
The neurobiology of X-linked adrenoleukodystrophy, a demyelinating peroxisomal disorder
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
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6 July 2018
Plasma and red blood cell fatty acids in peroxisomal disorders
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
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6 July 2018
Cytokine-induced accumulation of very long-chain fatty acids in rat C6 glial cells: implication for X-adrenoleukodystrophy.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
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6 July 2018
Peroxisomal disorders: genotype, phenotype, major neuropathologic lesions, and pathogenesis.
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6 July 2018
Targeted inactivation of the X-linked adrenoleukodystrophy gene in mice
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
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6 July 2018
A mouse model for X-linked adrenoleukodystrophy
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
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6 July 2018
Modulation of endogenous antioxidant enzymes by nitric oxide in rat C6 glial cells.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
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6 July 2018
The ABC transporter proteins Pat1 and Pat2 are required for import of long-chain fatty acids into peroxisomes of Saccharomyces cerevisiae
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
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6 July 2018
Putative X-linked adrenoleukodystrophy gene shares unexpected homology with ABC transporters
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
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6 July 2018
Incorporation of acetyl-CoA generated from peroxisomal beta-oxidation into ethanolamine plasmalogen of rat liver
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
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6 July 2018
The pathology of peroxisomal disorders with pathogenetic considerations.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
retrieved
6 July 2018
Interactions of a very long chain fatty acid with model membranes and serum albumin. Implications for the pathogenesis of adrenoleukodystrophy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
retrieved
6 July 2018
PXA1, a possible Saccharomyces cerevisiae ortholog of the human adrenoleukodystrophy gene
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
retrieved
6 July 2018
Membrane microviscosity is increased in the erythrocytes of patients with adrenoleukodystrophy and adrenomyeloneuropathy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
retrieved
6 July 2018
Identification of the inflammatory cells in the central nervous system of patients with adrenoleukodystrophy.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
retrieved
6 July 2018
Effects of long-chain, saturated fatty acids on membrane microviscosity and adrenocorticotropin responsiveness of human adrenocortical cells in vitro
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
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6 July 2018
Invited review: motor neuropathies, motor neuron disorders, and antiglycolipid antibodies
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
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6 July 2018
Phospholipids in X-linked adrenoleukodystrophy white matter: fatty acid abnormalities before the onset of demyelination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
retrieved
6 July 2018
The inflammatory myelinopathy of adreno-leukodystrophy: cells, effector molecules, and pathogenetic implications
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
retrieved
6 July 2018
Brain gangliosides in adrenoleukodystrophy.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
retrieved
6 July 2018
Inducible nitric oxide synthase in the central nervous system of patients with X-adrenoleukodystrophy.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00392.X
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21 January 2018
The dorsal root ganglia in adrenomyeloneuropathy: neuronal atrophy and abnormal mitochondria.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00392.X
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21 January 2018
Valproic acid induces antioxidant effects in X-linked adrenoleukodystrophy
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
retrieved
27 October 2018
Plasmalogens participate in very-long-chain fatty acid-induced pathology
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
retrieved
27 October 2018
Is microglial apoptosis an early pathogenic change in cerebral X-linked adrenoleukodystrophy?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
retrieved
27 October 2018
Early oxidative damage underlying neurodegeneration in X-adrenoleukodystrophy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
retrieved
27 October 2018
Lack of adrenoleukodystrophy protein enhances oligodendrocyte disturbance and microglia activation in mice with combined Abcd1/Mag deficiency.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
retrieved
27 October 2018
Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
retrieved
27 October 2018
The effect of Lorenzo's oil on oxidative stress in X-linked adrenoleukodystrophy.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
retrieved
27 October 2018
Adreno-leukodystrophy: oxidative stress of mice and men.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
retrieved
27 October 2018
Inactivation of the peroxisomal ABCD2 transporter in the mouse leads to late-onset ataxia involving mitochondria, Golgi and endoplasmic reticulum damage.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
retrieved
27 October 2018
Adreno-leukodystrophy: a personal historical note.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
retrieved
27 October 2018
Impaired peroxisomal function in the central nervous system with inflammatory disease of experimental autoimmune encephalomyelitis animals and protection by lovastatin treatment.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
retrieved
27 October 2018
Evidence that oxidative stress is increased in patients with X-linked adrenoleukodystrophy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
retrieved
27 October 2018
Correlation of very long chain fatty acid accumulation and inflammatory disease progression in childhood X-ALD: implications for potential therapies.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
retrieved
27 October 2018
Late onset neurological phenotype of the X-ALD gene inactivation in mice: a mouse model for adrenomyeloneuropathy.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
retrieved
27 October 2018
Endotoxin-induced alterations of lipid and fatty acid compositions in rat liver peroxisomes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
retrieved
27 October 2018
Lipid and fatty acid composition of brain tissue from adrenoleukodystrophy patients
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
retrieved
27 October 2018
Functional overlap between ABCD1 (ALD) and ABCD2 (ALDR) transporters: a therapeutic target for X-adrenoleukodystrophy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
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9 December 2018
Endotoxin induces structure-function alterations of rat liver peroxisomes: Kupffer cells released factors as possible modulators
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021280
retrieved
9 December 2018
Analysis of very long-chain fatty acids using electrospray ionization mass spectrometry
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20626745
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Combined liquid chromatography-tandem mass spectrometry as an analytical method for high throughput screening for X-linked adrenoleukodystrophy and other peroxisomal disorders: preliminary findings
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20626745
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Suppression of peroxisomal lipid beta-oxidation enzymes of TNF-alpha
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20626745
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Tumor necrosis factor-α and X-linked adrenoleukodystrophy
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20626745
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Fatty alcohol synthesis accompanied with chain elongation in liver peroxisomes
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20626745
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Toxic effects of X-linked adrenoleukodystrophy-associated, very long chain fatty acids on glial cells and neurons from rat hippocampus in culture
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20626745
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1111/J.1750-3639.2010.00392.X
1 reference
stated in
Europe PubMed Central
PMC publication ID
3021280
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20626745%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 February 2020
PMC publication ID
3021280
1 reference
stated in
Europe PubMed Central
PMC publication ID
3021280
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20626745%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 February 2020
PubMed publication ID
20626745
1 reference
stated in
Europe PubMed Central
PMC publication ID
3021280
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20626745%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 February 2020
ResearchGate publication ID
45183986
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