(Q34497232)

English

The Nox1/4 Dual Inhibitor GKT137831 or Nox4 Knockdown Inhibits Angiotensin-II-Induced Adult Mouse Cardiac Fibroblast Proliferation and Migration. AT1 Physically Associates With Nox4.

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Europe PubMed Central

PubMed publication ID

2 August 2017

The Nox1/4 Dual Inhibitor GKT137831 or Nox4 Knockdown Inhibits Angiotensin-II-Induced Adult Mouse Cardiac Fibroblast Proliferation and Migration. AT1 Physically Associates With Nox4. (English)

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Patrice Delafontaine

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Patrice Delafontaine

5

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author name string

Naveen K Somanna

1

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Anthony J Valente

2

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Maike Krenz

3

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

William P Fay

4

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Bysani Chandrasekar

6

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Europe PubMed Central

PubMed publication ID

2 August 2017

publication date

7 October 2015

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Journal of Cellular Physiology

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

231

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

1130-1141

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Inflammation, immunity, and hypertensive end-organ damage

1 reference

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7 July 2018

Interleukin-18 mediates interleukin-1-induced cardiac dysfunction

1 reference

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7 July 2018

Acetylsalicylic acid inhibits IL-18-induced cardiac fibroblast migration through the induction of RECK

1 reference

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7 July 2018

Angiotensin II stimulates cardiac fibroblast migration via the differential regulation of matrixins and RECK

1 reference

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7 July 2018

The pathogenesis of cardiac fibrosis.

1 reference

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7 July 2018

Recruitment of Nox4 to a plasma membrane scaffold is required for localized reactive oxygen species generation and sustained Src activation in response to insulin-like growth factor-I.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5237386

7 July 2018

Interleukin-18 enhances IL-18R/Nox1 binding, and mediates TRAF3IP2-dependent smooth muscle cell migration. Inhibition by simvastatin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5237386

7 July 2018

CIKS (Act1 or TRAF3IP2) mediates high glucose-induced endothelial dysfunction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5237386

7 July 2018

The Nox4 inhibitor GKT137831 attenuates hypoxia-induced pulmonary vascular cell proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5237386

7 July 2018

Angiotensin II enhances AT1-Nox1 binding and stimulates arterial smooth muscle cell migration and proliferation through AT1, Nox1, and interleukin-18.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5237386

7 July 2018

Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5237386

7 July 2018

Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5237386

7 July 2018

NOX5: from basic biology to signaling and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5237386

7 July 2018

Angiotensin-II type 1 receptor and NOX2 mediate TCF/LEF and CREB dependent WISP1 induction and cardiomyocyte hypertrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5237386

7 July 2018

The E-loop is involved in hydrogen peroxide formation by the NADPH oxidase Nox4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5237386

7 July 2018

Targeting the ACE2-Ang-(1-7) pathway in cardiac fibroblasts to treat cardiac remodeling and heart failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5237386

7 July 2018

Effects of interleukin-18 on cardiac fibroblast function and gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5237386

7 July 2018

First in Class, Potent, and Orally Bioavailable NADPH Oxidase Isoform 4 (Nox4) Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5237386

7 July 2018

PPAR{gamma} regulates hypoxia-induced Nox4 expression in human pulmonary artery smooth muscle cells through NF-{kappa}B.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5237386

7 July 2018

The role of inflammatory and fibrogenic pathways in heart failure associated with aging.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5237386

7 July 2018

Lysyl oxidase interacts with AGE signalling to modulate collagen synthesis in polycystic ovarian tissue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5237386

7 July 2018

IL-18 induction of osteopontin mediates cardiac fibrosis and diastolic dysfunction in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5237386

7 July 2018

Classical inhibitors of NOX NAD(P)H oxidases are not specific.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5237386

7 July 2018

Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5237386

7 July 2018

Wnt-induced secreted protein-1 is a prohypertrophic and profibrotic growth factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5237386

7 July 2018

ANG II-induced cell proliferation is dually mediated by c-Src/Yes/Fyn-regulated ERK1/2 activation in the cytoplasm and PKCzeta-controlled ERK1/2 activity within the nucleus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5237386

7 July 2018

NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5237386

7 July 2018

H2O2 activates Nox4 through PLA2-dependent arachidonic acid production in adult cardiac fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5237386

7 July 2018

Diphenyleneiodonium inhibits the cell redox metabolism and induces oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5237386

7 July 2018

Fibrosis in hypertensive heart disease: role of the renin-angiotensin-aldosterone system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5237386

7 July 2018

TNF-alpha and H2O2 induce IL-18 and IL-18R beta expression in cardiomyocytes via NF-kappa B activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5237386

7 July 2018

A fluorometric assay for detection of lysyl oxidase enzyme activity in biological samples

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5237386

7 July 2018

Regulation of IL-18 (IFN-gamma-inducing factor) gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5237386

7 July 2018

Parsing the role of NADPH oxidase enzymes and reactive oxygen species in heart failure

1 reference

https://api.crossref.org/works/10.1002%2FJCP.25210

21 January 2018

Aldosterone-induced cardiomyocyte growth, and fibroblast migration and proliferation are mediated by TRAF3IP2.

1 reference

https://api.crossref.org/works/10.1002%2FJCP.25210

21 January 2018

Angiotensin II type 2 receptor is upregulated in human heart with interstitial fibrosis, and cardiac fibroblasts are the major cell type for its expression

1 reference

https://api.crossref.org/works/10.1002%2FJCP.25210

21 January 2018

Induction of cardiac fibroblast lysyl oxidase by TGF-β1 requires PI3K/Akt, Smad3, and MAPK signaling.

1 reference

https://api.crossref.org/works/10.1002%2FJCP.25210

21 January 2018

NADPH oxidase 4 induces cardiac fibrosis and hypertrophy through activating Akt/mTOR and NFκB signaling pathways

1 reference

https://api.crossref.org/works/10.1002%2FJCP.25210

21 January 2018

Interleukin-18-induced human coronary artery smooth muscle cell migration is dependent on NF-kappaB- and AP-1-mediated matrix metalloproteinase-9 expression and is inhibited by atorvastatin

1 reference

https://pubmed.ncbi.nlm.nih.gov/26445208

12 December 2020

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Identifiers

10.1002/JCP.25210

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

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