(Q34499838)

English

Glycogen synthase kinase-3β inactivation inhibits tumor necrosis factor-α production in microglia by modulating nuclear factor κB and MLK3/JNK signaling cascades

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Glycogen synthase kinase-3β inactivation inhibits tumor necrosis factor-α production in microglia by modulating nuclear factor κB and MLK3/JNK signaling cascades (English)

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

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author name string

Mei-Jen Wang

1

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Hsin-Yi Huang

2

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Wu-Fu Chen

3

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Hui-Fen Chang

4

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Jon-Son Kuo

5

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

publication date

31 December 2010

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Journal of Neuroinflammation

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

7

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

99

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

https://scigraph.springernature.com/pub.10.1186/1742-2094-7-99

0 references

Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology

1 reference

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GSK3 beta N-terminus binding to p53 promotes its acetylation

1 reference

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Glycogen synthase kinase-3 negatively regulates anti-inflammatory interleukin-10 for lipopolysaccharide-induced iNOS/NO biosynthesis and RANTES production in microglial cells

1 reference

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Glycogen synthase kinase-3 regulates microglial migration, inflammation, and inflammation-induced neurotoxicity

1 reference

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Hepatocyte growth factor suppresses proinflammatory NFkappaB activation through GSK3beta inactivation in renal tubular epithelial cells

1 reference

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Rapid cognitive improvement in Alzheimer's disease following perispinal etanercept administration

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Glial reactions in Parkinson's disease

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Glycogen synthase kinase-3beta induces neuronal cell death via direct phosphorylation of mixed lineage kinase 3.

1 reference

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Physiological roles of MKK4 and MKK7: insights from animal models

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Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson's disease

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Inflammation in Alzheimer disease: driving force, bystander or beneficial response?

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Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics

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Novel anti-inflammatory role for glycogen synthase kinase-3beta in the inhibition of tumor necrosis factor-alpha- and interleukin-1beta-induced inflammatory gene expression

1 reference

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7 July 2018

Glycogen synthase kinase 3beta functions to specify gene-specific, NF-kappaB-dependent transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022821

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Stimulus specificity of gene expression programs determined by temporal control of IKK activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022821

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Achieving stability of lipopolysaccharide-induced NF-kappaB activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022821

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Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022821

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The neuroprotective effects of K252a through inhibiting MLK3/MKK7/JNK3 signaling pathway on ischemic brain injury in rat hippocampal CA1 region

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022821

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Both the establishment and the maintenance of neuronal polarity require active mechanisms: critical roles of GSK-3beta and its upstream regulators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022821

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Glia and their cytokines in progression of neurodegeneration

1 reference

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Glycogen synthase kinase 3beta is a negative regulator of growth factor-induced activation of the c-Jun N-terminal kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022821

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Phosphorylation of serine 468 by GSK-3beta negatively regulates basal p65 NF-kappaB activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022821

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NF-kappaB: a multifaceted transcription factor regulated at several levels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022821

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The arachidonic acid 5-lipoxygenase inhibitor nordihydroguaiaretic acid inhibits tumor necrosis factor alpha activation of microglia and extends survival of G93A-SOD1 transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022821

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Signaling to NF-kappaB

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022821

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Shaping the nuclear action of NF-kappaB

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022821

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Glycogen synthase kinase 3beta-mediated apoptosis of primary cortical astrocytes involves inhibition of nuclear factor kappaB signaling

1 reference

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Synthetic small molecules that control stem cell fate

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IKK beta plays an essential role in the phosphorylation of RelA/p65 on serine 536 induced by lipopolysaccharide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022821

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Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)

1 reference

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GSK-3: tricks of the trade for a multi-tasking kinase

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Glycogen synthase kinase 3 beta is a natural activator of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 1 (MEKK1).

1 reference

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Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB.

1 reference

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Post-activation turn-off of NF-kappa B-dependent transcription is regulated by acetylation of p65

1 reference

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Regulation of the transcriptional activity of the nuclear factor-kappaB p65 subunit.

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Duration of nuclear NF-kappaB action regulated by reversible acetylation

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The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling

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The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis

1 reference

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MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines

1 reference

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Signal transduction by the JNK group of MAP kinases

1 reference

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1 reference

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Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation

1 reference

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Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK-3

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c-Jun N-terminal kinases (JNKs) mediate pro-inflammatory actions of microglia.

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Tumor necrosis factor-α−308A/G polymorphism is associated with age at onset of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21194439

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based on heuristic

inferred from PubMed ID database lookup

Glycogen synthase kinase-3beta suppresses tumor necrosis factor-alpha expression in cardiomyocytes during lipopolysaccharide stimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21194439

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based on heuristic

inferred from PubMed ID database lookup

A model for NF-kappa B regulation by GSK-3 beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/21194439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/21194439

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based on heuristic

inferred from PubMed ID database lookup

Human ramified microglial cells produce nitric oxide upon Escherichia coli lipopolysaccharide and tumor necrosis factor α stimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21194439

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based on heuristic

inferred from PubMed ID database lookup

Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/21194439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1742-2094-7-99

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

ResearchGate publication ID

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