(Q34810173)

4 August 2017

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title

Mixed-lineage kinase control of JNK and p38 MAPK pathways (English)

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4 August 2017

Kathleen A Gallo

1

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4 August 2017

Gary L Johnson

series ordinal

2

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4 August 2017

language of work or name

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1 September 2002

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Nature Reviews Molecular Cell Biology

4 August 2017

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4 August 2017

3

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4 August 2017

663-672

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4 August 2017

9

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https://scigraph.springernature.com/pub.10.1038/nrm906

4 August 2017

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21 January 2018

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The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Cloning of a novel putative protein kinase having a leucine zipper domain from human brain

21 January 2018

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Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain

21 January 2018

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The crystal structure of an Eph receptor SAM domain reveals a mechanism for modular dimerization

21 January 2018

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Cloning and expression of ZAK, a mixed lineage kinase-like protein containing a leucine-zipper and a sterile-alpha motif

21 January 2018

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Activation of the JNK pathway during dorsal closure in Drosophila requires the mixed lineage kinase, slipper

21 January 2018

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Sequence requirements for coiled-coils: analysis with lambda repressor-GCN4 leucine zipper fusions

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X-ray structure of the GCN4 leucine zipper, a two-stranded, parallel coiled coil

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Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization.

21 January 2018

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Identification and characterization of functional domains in a mixed lineage kinase LZK

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Mixed lineage kinase-dependent JNK activation is governed by interactions of scaffold protein JIP with MAPK module components

21 January 2018

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Characterization of dual leucine zipper-bearing kinase, a mixed lineage kinase present in synaptic terminals whose phosphorylation state is regulated by membrane depolarization via calcineurin

21 January 2018

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Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK-3

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Autoinhibition of mixed lineage kinase 3 through its Src homology 3 domain

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The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

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Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

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The kinase activation loop is the key to mixed lineage kinase-3 activation via both autophosphorylation and hematopoietic progenitor kinase 1 phosphorylation

21 January 2018

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Identification of in vivo phosphorylation sites of MLK3 by mass spectrometry and phosphopeptide mapping

21 January 2018

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Activated JNK phosphorylates the c-terminal domain of MLK2 that is required for MLK2-induced apoptosis

21 January 2018

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Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway

21 January 2018

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Dual leucine zipper-bearing kinase (DLK) activates p46SAPK and p38mapk but not ERK2.

21 January 2018

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Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3

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21 January 2018

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Drosophila Jun kinase regulates expression of decapentaplegic via the ETS-domain protein Aop and the AP-1 transcription factor DJun during dorsal closure

21 January 2018

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hemipterous encodes a novel Drosophila MAP kinase kinase, required for epithelial cell sheet movement.

21 January 2018

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The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye.

21 January 2018

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Stress signaling in Drosophila

21 January 2018

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Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kappaB-dependent innate immune responses

21 January 2018

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Oncogenic transformation by ras and fos is mediated by c-Jun N-terminal phosphorylation

21 January 2018

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21 January 2018

Jun, the oncoprotein.

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Role of MLK3-mediated activation of p70 S6 kinase in Rac1 transformation

21 January 2018

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The GABP-responsive element of the interleukin-2 enhancer is regulated by JNK/SAPK-activating pathways in T lymphocytes

21 January 2018

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Vav synergizes with protein kinase C theta to mediate IL-4 gene expression in response to CD28 costimulation in T cells

21 January 2018

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Mixed-lineage kinase 3 delivers CD3/CD28-derived signals into the IkappaB kinase complex

21 January 2018

1 reference

Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway

21 January 2018

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MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta

21 January 2018

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Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-beta

21 January 2018

1 reference

The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway

21 January 2018

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Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor

21 January 2018

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Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis

21 January 2018

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Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

21 January 2018

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Activation of MLK2-mediated signaling cascades by polyglutamine-expanded huntingtin

21 January 2018

1 reference

The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis

21 January 2018

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Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

21 January 2018

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Kainate receptor activation induces mixed lineage kinase-mediated cellular signaling cascades via post-synaptic density protein 95

21 January 2018

1 reference

Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice

21 January 2018

1 reference

Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95

21 January 2018

1 reference

Mechanism of activation of ERK2 by dual phosphorylation

21 January 2018

1 reference

Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons

21 January 2018

1 reference

The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2

21 January 2018

1 reference

Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction

21 January 2018

1 reference

Neurotrophic 3,9-bis[(alkylthio)methyl]-and-bis(alkoxymethyl)-K-252a derivatives

21 January 2018

1 reference

Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family.

21 January 2018

1 reference

Different Mitogen-activated Protein Kinase Signaling Pathways Cooperate to Regulate Tumor Necrosis Factor α Gene Expression in T Lymphocytes

21 January 2018

1 reference

MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6

21 January 2018

1 reference

Identification of structural and functional domains in mixed lineage kinase dual leucine zipper-bearing kinase required for complex formation and stress-activated protein kinase activation

31 March 2020

1 reference

Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway. A role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel member of the mixed lineage kinase family

31 March 2020

1 reference

BAX translocation is a critical event in neuronal apoptosis: regulation by neuroprotectants, BCL-2, and caspases

31 March 2020

1 reference

A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death

31 March 2020

1 reference

Role of the Jun kinase pathway in the regulation of c-Jun expression and apoptosis in sympathetic neurons.

31 March 2020

1 reference

Evidence for a role of mixed lineage kinases in neuronal apoptosis

31 March 2020

1 reference

Inhibition of the c-Jun N-terminal kinase signaling pathway by the mixed lineage kinase inhibitor CEP-1347 (KT7515) preserves metabolism and growth of trophic factor-deprived neurons.

31 March 2020

1 reference

Mixed lineage kinase 2 interacts with clathrin and influences clathrin-coated vesicle trafficking

31 March 2020

1 reference

c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK

31 March 2020

1 reference

Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRM906

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Dimensions Publication ID

4 August 2017

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