(Q34509788)

2 August 2017

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title

gamma-Secretase inhibitors as molecular probes of presenilin function (English)

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2 August 2017

Wolfe MS

1

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2 August 2017

publication date

1 October 2001

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Journal of Molecular Neuroscience

2 August 2017

published in

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2 August 2017

volume

17

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2 August 2017

issue

2

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2 August 2017

page(s)

199-204

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https://scigraph.springernature.com/pub.10.1385/jmn:17:2:199

2 August 2017

exact match

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cites work

Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix

1 reference

12 December 2020

Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation

1 reference

12 December 2020

Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

1 reference

12 December 2020

Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities

1 reference

12 December 2020

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

12 December 2020

Difluoro ketone peptidomimetics suggest a large S1 pocket for Alzheimer's gamma-secretase: implications for inhibitor design

1 reference

12 December 2020

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

12 December 2020

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.

1 reference

12 December 2020

Design and synthesis of potent and specific renin inhibitors containing difluorostatine, difluorostatone, and related analogues

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12 December 2020

The Role of presenilins in gamma-secretase activity

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12 December 2020

HIV protease: a novel chemotherapeutic target for AIDS.

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12 December 2020

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

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12 December 2020

Endoproteolytic processing and stabilization of wild-type and mutant presenilin

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12 December 2020

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

1 reference

12 December 2020

Mode of inhibition of acid proteases by pepstatin

1 reference

12 December 2020

Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease

1 reference

12 December 2020

Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease

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12 December 2020

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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12 December 2020

Skeletal and CNS defects in Presenilin-1-deficient mice

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12 December 2020

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

12 December 2020

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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12 December 2020

L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

1 reference

12 December 2020

Effects of PS1 deficiency on membrane protein trafficking in neurons

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12 December 2020

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

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12 December 2020

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

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12 December 2020

Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling

1 reference

12 December 2020

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

1 reference

12 December 2020

A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.

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12 December 2020

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

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12 December 2020

Inhibition of beta-amyloid formation identifies proteolytic precursors and subcellular site of catabolism

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12 December 2020

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1 reference

12 December 2020

Crystallographic analysis of transition state mimics bound to penicillopepsin: difluorostatine- and difluorostatone-containing peptides

1 reference

12 December 2020

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1 reference

12 December 2020

Alzheimer's disease. A firm base for drug development.

1 reference

12 December 2020

Inhibition and catalytic mechanism of HIV-1 aspartic protease

1 reference

12 December 2020

The carboxyl termini of beta-amyloid peptides 1-40 and 1-42 are generated by distinct gamma-secretase activities

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12 December 2020

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

12 December 2020

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

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12 December 2020

Identifiers

DOI

10.1385/JMN:17:2:199

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Dimensions Publication ID

2 August 2017

1051705064

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