(Q34515268)

2 August 2017

title

QLT091001, a 9-cis-retinal analog, is well-tolerated by retinas of mice with impaired visual cycles (English)

1 reference

2 August 2017

9

Krzysztof Palczewski

1 reference

2 August 2017

8

Grazyna Palczewska

1 reference

2 August 2017

5

Songqi Gao

1 reference

2 August 2017

2

Zhiqian Dong

1 reference

2 August 2017

1

Tadao Maeda

1 reference

2 August 2017

Hui Jin

3

1 reference

2 August 2017

Osamu Sawada

series ordinal

4

1 reference

2 August 2017

Deepank Utkhede

series ordinal

6

1 reference

2 August 2017

Wendy Monk

series ordinal

7

1 reference

2 August 2017

language of work or name

English

0 references

publication date

17 January 2013

1 reference

Investigative Ophthalmology Visual Science

2 August 2017

published in

1 reference

2 August 2017

volume

54

1 reference

2 August 2017

issue

1

1 reference

2 August 2017

page(s)

455-466

1 reference

describes a project that uses

2 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4686220/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

M-opsin protein degradation is inhibited by MG-132 in Rpe65⁻/⁻ retinal explant culture

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Chemical chaperone TUDCA preserves cone photoreceptors in a mouse model of Leber congenital amaurosis

7 July 2018

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Retinal photodamage mediated by all-trans-retinal

7 July 2018

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Mechanism of all-trans-retinal toxicity with implications for stargardt disease and age-related macular degeneration

7 July 2018

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Dietary 9-cis-β,β-carotene fails to rescue vision in mouse models of leber congenital amaurosis

7 July 2018

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Cone opsin determines the time course of cone photoreceptor degeneration in Leber congenital amaurosis

7 July 2018

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Key enzymes of the retinoid (visual) cycle in vertebrate retina

7 July 2018

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Toll-like receptor 3 is required for development of retinopathy caused by impaired all-trans-retinal clearance in mice

7 July 2018

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Noninvasive multiphoton fluorescence microscopy resolves retinol and retinal condensation products in mouse eyes

7 July 2018

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Blind dogs that can see: pharmacological treatment of Leber congenital amaurosis caused by a defective visual cycle

7 July 2018

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7 July 2018

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7 July 2018

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Palmitoylation stabilizes unliganded rod opsin

7 July 2018

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7 July 2018

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The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision

7 July 2018

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7 July 2018

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7 July 2018

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Evaluation of potential therapies for a mouse model of human age-related macular degeneration caused by delayed all-trans-retinal clearance

7 July 2018

1 reference

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Evaluation of 9-cis-retinyl acetate therapy in Rpe65-/- mice

7 July 2018

1 reference

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Loss of cone photoreceptors caused by chromophore depletion is partially prevented by the artificial chromophore pro-drug, 9-cis-retinyl acetate

7 July 2018

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Impact of retinal disease-associated RPE65 mutations on retinoid isomerization

7 July 2018

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Effects of long-term administration of 9-cis-retinyl acetate on visual function in mice

7 July 2018

1 reference

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7 July 2018

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7 July 2018

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The molecular basis of retinoid absorption: a genetic dissection

7 July 2018

1 reference

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Rpe65-/- and Lrat-/- mice: comparable models of leber congenital amaurosis

7 July 2018

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Reversal of blindness in animal models of leber congenital amaurosis using optimized AAV2-mediated gene transfer

7 July 2018

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Improvement in rod and cone function in mouse model of Fundus albipunctatus after pharmacologic treatment with 9-cis-retinal

7 July 2018

1 reference

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Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents

7 July 2018

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7 July 2018

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HINDERED CIS ISOMERS OF VITAMIN A AND RETINENE: THE STRUCTURE OF THE NEO-B ISOMER.

7 July 2018

1 reference

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Pharmacological and rAAV gene therapy rescue of visual functions in a blind mouse model of Leber congenital amaurosis.

7 July 2018

1 reference

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A critical role of CaBP4 in the cone synapse

7 July 2018

1 reference

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Rpe65 is the retinoid isomerase in bovine retinal pigment epithelium

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686220

Acyl CoA:retinol acyltransferase (ARAT) activity is present in bovine retinal pigment epithelium

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686220

Downregulation of cone-specific gene expression and degeneration of cone photoreceptors in the Rpe65-/- mouse at early ages

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686220

Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686220

Dark adaptation and the retinoid cycle of vision

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686220

Noninvasive two-photon imaging reveals retinyl ester storage structures in the eye

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686220

Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686220

Biochemical and physiological properties of rhodopsin regenerated with 11-cis-6-ring- and 7-ring-retinals

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686220

Recovery of visual functions in a mouse model of Leber congenital amaurosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686220

Confronting complexity: the interlink of phototransduction and retinoid metabolism in the vertebrate retina

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686220

Mutations in the gene encoding lecithin retinol acyltransferase are associated with early-onset severe retinal dystrophy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686220

Phototransduction in transgenic mice after targeted deletion of the rod transducin alpha -subunit

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686220

Rapid restoration of visual pigment and function with oral retinoid in a mouse model of childhood blindness

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686220

Molecular and biochemical characterization of lecithin retinol acyltransferase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686220

Congenital stationary night blindness in the dog: common mutation in the RPE65 gene indicates founder effect.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686220

Mutations in RPE65 cause autosomal recessive childhood-onset severe retinal dystrophy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686220

Evidence for a lecithin-retinol acyltransferase activity in the rat small intestine

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686220

S-opsin protein is incompletely modified during N-glycan processing in Rpe65(-/-) mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686220

Lentiviral gene transfer-mediated cone vision restoration in RPE65 knockout mice

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686220

RPE65 gene delivery restores isomerohydrolase activity and prevents early cone loss in Rpe65-/- mice

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686220

Spontaneous activity of opsin apoprotein is a cause of Leber congenital amaurosis

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686220

Acute radiolabeling of retinoids in eye tissues of normal and rpe65-deficient mice.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686220

Gene therapy restores vision in a canine model of childhood blindness

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686220

Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686220

Retinol esterification in bovine retinal pigment epithelium: reversibility of lecithin:retinol acyltransferase

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686220

Rhodopsin analogues from highly hindered 7-cis isomers of retinal

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23249702

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1167/IOVS.12-11152

1 reference

2 August 2017

1 reference

2 August 2017

1 reference