(Q34518173)

2 August 2017

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title

Strategies for engineering human chromosomes with therapeutic potential (English)

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2 August 2017

1

Richard Saffery

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2 August 2017

K H Andy Choo

2

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2 August 2017

publication date

1 January 2002

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2 August 2017

published in

Journal of Gene Medicine

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2 August 2017

volume

4

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2 August 2017

issue

1

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2 August 2017

page(s)

5-13

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Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease

2 August 2017

cites work

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Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector.

21 January 2018

1 reference

Mammalian artificial chromosomes

21 January 2018

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Formation of de novo centromeres and construction of first-generation human artificial microchromosomes

21 January 2018

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Construction of YAC-based mammalian artificial chromosomes

21 January 2018

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Functional complementation of a genetic deficiency with human artificial chromosomes.

21 January 2018

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Human artificial chromosomes generated by modification of a yeast artificial chromosome containing both human alpha satellite and single-copy DNA sequences.

21 January 2018

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Mini-chromosomes derived from the human Y chromosome by telomere directed chromosome breakage

21 January 2018

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Efficient male and female germline transmission of a human chromosomal vector in mice

21 January 2018

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Manipulation of human minichromosomes to carry greater than megabase-sized chromosome inserts

21 January 2018

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Construction of neocentromere-based human minichromosomes by telomere-associated chromosomal truncation.

21 January 2018

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Lack of expression from a retroviral vector after transduction of murine hematopoietic stem cells is associated with methylation in vivo

21 January 2018

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Gene silencing as a threat to the success of gene therapy

21 January 2018

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Safety considerations in somatic gene therapy of human disease with retrovirus vectors

21 January 2018

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Incidence and prevalence of neutralizing antibodies to the common adenoviruses in children with cystic fibrosis: implication for gene therapy with adenovirus vectors

21 January 2018

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Adenoviral vectors for in vivo gene delivery to oligodendrocytes: transgene expression and cytopathic consequences

21 January 2018

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Stable gene expression from a mammalian artificial chromosome

21 January 2018

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Genomics and gene therapy. Artificial chromosomes coming to life

21 January 2018

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Artificial chromosomes: ideal vectors?

21 January 2018

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Stability of a functional murine satellite DNA-based artificial chromosome across mammalian species

21 January 2018

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Generation of transgenic mice and germline transmission of a mammalian artificial chromosome introduced into embryos by pronuclear microinjection.

21 January 2018

1 reference

Gene targeting to the centromeric DNA of a human minichromosome

21 January 2018

1 reference

Efficient modification of human chromosomal alleles using recombination-proficient chicken/human microcell hybrids.

21 January 2018

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Low levels of tissue factor are compatible with development and hemostasis in mice.

21 January 2018

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Use of a human minichromosome as a cloning and expression vector for mammalian cells

21 January 2018

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The accuracy of segregation of human mini-chromosomes varies in different vertebrate cell lines, correlates with the extent of centromere formation and provides evidence for a trans-acting centromere maintenance activity

21 January 2018

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Molecular and cytological analysis of a 5.5 Mb minichromosome

21 January 2018

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Targeted integration of a dominant neo(R) marker into a 2- to 3-Mb human minichromosome and transfer between cells

21 January 2018

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Telomere-associated chromosome fragmentation: applications in genome manipulation and analysis

21 January 2018

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A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes

21 January 2018

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Generation of an approximately 2.4 Mb human X centromere-based minichromosome by targeted telomere-associated chromosome fragmentation in DT40.

21 January 2018

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Human mini-chromosomes in mouse embryonal stem cells.

21 January 2018

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Differential stability of a human mini-chromosome in mouse cell lines

21 January 2018

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Human mini-chromosomes with minimal centromeres

21 January 2018

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Domain organization at the centromere and neocentromere

21 January 2018

1 reference

21 January 2018

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Human centromeres and neocentromeres show identical distribution patterns of >20 functionally important kinetochore-associated proteins

21 January 2018

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Sequence analysis of an 80 kb human neocentromere

21 January 2018

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The 10q25 neocentromere and its inactive progenitor have identical primary nucleotide sequence: further evidence for epigenetic modification

21 January 2018

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Isolation of pluripotent embryonic stem cells from reprogrammed adult mouse somatic cell nuclei

21 January 2018

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Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells.

21 January 2018

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Analysis of extrachromosomal structures containing human centromeric alphoid satellite DNA sequences in mouse cells

21 January 2018

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Assay of centromere function using a human artificial chromosome

21 January 2018

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Mammalian artificial chromosome formation from circular alphoid input DNA does not require telomere repeats

21 January 2018

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The Assembly of Large BACs by in Vivo Recombination

21 January 2018

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De novo chromosome formations by large-scale amplification of the centromeric region of mouse chromosomes

21 January 2018

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Stability of transferred human chromosome fragments in cultured cells and in mice

21 January 2018

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A functional neo-centromere formed through activation of a latent human centromere and consisting of non-alpha-satellite DNA

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JGM.236

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2 August 2017

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