(Q34518245)

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Interrogating two schedules of the AKT inhibitor MK-2206 in patients with advanced solid tumors incorporating novel pharmacodynamic and functional imaging biomarkers

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scholarly article

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Europe PubMed Central

2 August 2017

Interrogating two schedules of the AKT inhibitor MK-2206 in patients with advanced solid tumors incorporating novel pharmacodynamic and functional imaging biomarkers (English)

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Europe PubMed Central

2 August 2017

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1 reference

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pharmacodynamics

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based on heuristic

inferred from title

9

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2 June 2020

19

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2 June 2020

author name string

Timothy A Yap

1

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2 June 2020

Li Yan

2

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2 June 2020

Amita Patnaik

3

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2 June 2020

Nina Tunariu

4

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2 June 2020

Andrea Biondo

5

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2 June 2020

Ivy Fearen

6

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2 June 2020

Kyriakos P Papadopoulos

7

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2 June 2020

David Olmos

8

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2 June 2020

Liliana Delgado

10

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2 June 2020

Ernestina Tetteh

11

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2 June 2020

Robert A Beckman

12

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2 June 2020

Lisa Lupinacci

13

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2 June 2020

Ruth Riisnaes

14

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2 June 2020

Shaun Decordova

15

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2 June 2020

Simon P Heaton

16

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2 June 2020

Karen Swales

17

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2 June 2020

Nandita M deSouza

18

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2 June 2020

Michelle D Garrett

20

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2 June 2020

Daniel M Sullivan

21

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2 June 2020

Johann S de Bono

22

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2 June 2020

Anthony W Tolcher

23

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2 June 2020

language of work or name

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19 September 2014

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Europe PubMed Central

2 August 2017

Clinical Cancer Research

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2 June 2020

20

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2 June 2020

22

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Europe PubMed Central

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2 June 2020

5672-5685

1 reference

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2 June 2020

Development of therapeutic combinations targeting major cancer signaling pathways

1 reference

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7 July 2018

Imaging vascular function for early stage clinical trials using dynamic contrast-enhanced magnetic resonance imaging.

1 reference

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7 July 2018

Functional imaging: what evidence is there for its utility in clinical trials of targeted therapies?

1 reference

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7 July 2018

Metabolic consequences of treatment with AKT inhibitor perifosine in breast cancer cells

1 reference

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7 July 2018

Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors

1 reference

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7 July 2018

First-in-man clinical trial of the oral pan-AKT inhibitor MK-2206 in patients with advanced solid tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233149

7 July 2018

Diffusion MR imaging for monitoring of treatment response

1 reference

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7 July 2018

Integrative genomic profiling of human prostate cancer

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7 July 2018

Perfusion MRI in the early clinical development of antivascular drugs: decorations or decision making tools?

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7 July 2018

The PI3K pathway as drug target in human cancer

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7 July 2018

Targeting PI3K signalling in cancer: opportunities, challenges and limitations

1 reference

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7 July 2018

Beyond chemotherapy: targeted therapies in ovarian cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233149

7 July 2018

Diffusion-weighted magnetic resonance imaging as a cancer biomarker: consensus and recommendations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233149

7 July 2018

Targeting the PI3K-AKT-mTOR pathway: progress, pitfalls, and promises

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7 July 2018

Application of meso scale technology for the measurement of phosphoproteins in human tumor xenografts

1 reference

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7 July 2018

Murine cell lines derived from Pten null prostate cancer show the critical role of PTEN in hormone refractory prostate cancer development

1 reference

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7 July 2018

DCE-MRI biomarkers in the clinical evaluation of antiangiogenic and vascular disrupting agents

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7 July 2018

The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice

1 reference

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7 July 2018

Informatics in Radiology (infoRAD): Magnetic Resonance Imaging Workbench: analysis and visualization of dynamic contrast-enhanced MR imaging data

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7 July 2018

The assessment of antiangiogenic and antivascular therapies in early-stage clinical trials using magnetic resonance imaging: issues and recommendations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233149

7 July 2018

New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233149

7 July 2018

Eligibility and response guidelines for phase II clinical trials in androgen-independent prostate cancer: recommendations from the Prostate-Specific Antigen Working Group.

1 reference

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7 July 2018

Toxicity and response criteria of the Eastern Cooperative Oncology Group

1 reference

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7 July 2018

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233149

7 July 2018

Evaluation and clinical analyses of downstream targets of the Akt inhibitor GDC-0068.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233149

27 October 2018

Primary human breast adenocarcinoma: imaging and histologic correlates of intrinsic susceptibility-weighted MR imaging before and during chemotherapy.

1 reference

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27 October 2018

Mechanism and management of AKT inhibitor-induced hyperglycemia

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27 October 2018

Allosteric inhibitors of Akt1 and Akt2: a naphthyridinone with efficacy in an A2780 tumor xenograft model

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27 October 2018

Computationally efficient vascular input function models for quantitative kinetic modelling using DCE-MRI.

1 reference

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27 October 2018

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1 reference

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27 October 2018

Identification of magnetic resonance detectable metabolic changes associated with inhibition of phosphoinositide 3-kinase signaling in human breast cancer cells

1 reference

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27 October 2018

Frequent mutation of the PIK3CA gene in ovarian and breast cancers.

1 reference

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27 October 2018

Re: New guidelines to evaluate the response to treatment in solid tumors (ovarian cancer).

1 reference

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27 October 2018

PIK3CA is implicated as an oncogene in ovarian cancer.

1 reference

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27 October 2018

Sequence mutations and amplification of PIK3CA and AKT2 genes in purified ovarian serous neoplasms

1 reference

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12 December 2020

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Identifiers

10.1158/1078-0432.CCR-14-0868

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2 June 2020

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Europe PubMed Central

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2 June 2020

1 reference

Europe PubMed Central

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2 June 2020

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