(Q34518460)

2 August 2017

title

Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci (English)

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2 August 2017

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14

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Francis S Collins

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Alan P. Boyle

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Alan P Boyle

9

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Gregory E. Crawford

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object named as

Gregory E Crawford

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2 August 2017

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Michael Boehnke

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NISC Comparative Sequencing Program

2 August 2017

11

object named as

NISC Comparative Sequencing Program

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2 August 2017

5

Lingyun Song

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2 August 2017

12

Elliott H Margulies

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2 August 2017

Michael L Stitzel

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2 August 2017

Praveen Sethupathy

2

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2 August 2017

Daniel S Pearson

3

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2 August 2017

Peter S Chines

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2 August 2017

Michael R Erdos

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2 August 2017

Ryan Welch

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Stephen C J Parker

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Laura J Scott

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2 August 2017

publication date

1 November 2010

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2 August 2017

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2 August 2017

volume

12

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2 August 2017

issue

5

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2 August 2017

page(s)

443-455

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Human RNA polymerase III transcriptomes and relationships to Pol II promoter chromatin and enhancer-binding factors

2 August 2017

cites work

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7 July 2018

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7 July 2018

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7 July 2018

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A map of open chromatin in human pancreatic islets

7 July 2018

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New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

7 July 2018

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Novel biological insights emerging from genetic studies of type 2 diabetes and related metabolic traits

7 July 2018

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7 July 2018

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The human insulin gene is part of a large open chromatin domain specific for human islets

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

7 July 2018

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Global mapping of protein-DNA interactions in vivo by digital genomic footprinting

7 July 2018

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Histone modifications at human enhancers reflect global cell-type-specific gene expression

7 July 2018

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Local DNA topography correlates with functional noncoding regions of the human genome

7 July 2018

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Detailed transcriptome atlas of the pancreatic beta cell

7 July 2018

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MicroRNA miR-7 is preferentially expressed in endocrine cells of the developing and adult human pancreas

7 July 2018

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Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

7 July 2018

1 reference

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Variants in MTNR1B influence fasting glucose levels

7 July 2018

1 reference

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Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains

7 July 2018

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Type 2 diabetes: new genes, new understanding

7 July 2018

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7 July 2018

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Model-based analysis of ChIP-Seq (MACS)

7 July 2018

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Genome-wide relationship between histone H3 lysine 4 mono- and tri-methylation and transcription factor binding

7 July 2018

1 reference

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Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026436

Genome-wide identification of in vivo protein-DNA binding sites from ChIP-Seq data

7 July 2018

1 reference

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On the origin of the beta cell

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026436

Combinatorial patterns of histone acetylations and methylations in the human genome

7 July 2018

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7 July 2018

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Mechanisms of disease:Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes

7 July 2018

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A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study

7 July 2018

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Quantitative differential expression analysis reveals miR-7 as major islet microRNA.

7 July 2018

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The replication of beta cells in normal physiology, in disease and for therapy

7 July 2018

1 reference

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Identification and characterization of cell type-specific and ubiquitous chromatin regulatory structures in the human genome

7 July 2018

1 reference

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Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

7 July 2018

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A chromatin landmark and transcription initiation at most promoters in human cells

7 July 2018

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7 July 2018

1 reference

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Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026436

High-resolution profiling of histone methylations in the human genome

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026436

Analysis of the vertebrate insulator protein CTCF-binding sites in the human genome

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026436

The role of chromatin during transcription

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026436

Chromatin modifications and their function

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026436

7 July 2018

The mammalian epigenome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026436

Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026436

FAIRE (Formaldehyde-Assisted Isolation of Regulatory Elements) isolates active regulatory elements from human chromatin

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026436

Statistics for ChIP-chip and DNase hypersensitivity experiments on NimbleGen arrays

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026436

Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026436

Discovery of functional noncoding elements by digital analysis of chromatin structure

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026436

Identifying gene regulatory elements by genome-wide recovery of DNase hypersensitive sites

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026436

Promoter elements in endocrine pancreas development and hormone regulation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026436

A closer look at long-range chromosomal interactions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026436

In vivo characterization of regulatory polymorphisms by allele-specific quantification of RNA polymerase loading

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026436

Regulation of insulin gene transcription

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026436

Fitting a mixture model by expectation maximization to discover motifs in biopolymers

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026436

PReMod: a database of genome-wide mammalian cis-regulatory module predictions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026436

Genome-wide computational prediction of transcriptional regulatory modules reveals new insights into human gene expression

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026436

10.1016/J.CMET.2010.09.012

27 October 2018

Identifiers

DOI

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2 August 2017

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2 August 2017

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