(Q34535740)

2 August 2017

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title

Complex regulatory mechanisms of telomerase activity in normal and cancer cells: how can we apply them for cancer therapy? (English)

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2 August 2017

Satoru Kyo

1

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2 August 2017

Masaki Inoue

series ordinal

2

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2 August 2017

language of work or name

English

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publication date

1 January 2002

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2 August 2017

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2 August 2017

21

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2 August 2017

688-697

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2 August 2017

4

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1205163

2 August 2017

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cites work

Telomere length predicts replicative capacity of human fibroblasts

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

Structure and function of telomeres

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

Extension of life-span by introduction of telomerase into normal human cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

The hTERTalpha splice variant is a dominant negative inhibitor of telomerase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

Histone deacetylation is involved in the transcriptional repression of hTERT in normal human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

The human telomerase catalytic subunit hTERT: organization of the gene and characterization of the promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

E2F-1 represses transcription of the human telomerase reverse transcriptase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

Telomerase repressor sequences on chromosome 3 and induction of permanent growth arrest in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

Histone deacetylase 1 can repress transcription by binding to Sp1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

The RNA component of human telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

Identification and characterization of negative regulatory elements of the human telomerase catalytic subunit (hTERT) gene promoter: possible role of MZF-2 in transcriptional repression of hTERT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

E box-dependent activation of telomerase by human papillomavirus type 16 E6 does not require induction of c-myc

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

Creation of human tumour cells with defined genetic elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

Telomerase activity in the regenerative basal layer of the epidermis inhuman skin and in immortal and carcinoma-derived skin keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

Telomeres shorten during ageing of human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

Histone deacetylase activity is required for full transcriptional repression by mSin3A

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

Functional requirement of p23 and Hsp90 in telomerase complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

Lack of cell cycle regulation of telomerase activity in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

Specific association of human telomerase activity with immortal cells and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

Transactivation of prothymosin alpha and c-myc promoters by human papillomavirus type 16 E6 protein

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

Telomerase activation by the E6 gene product of human papillomavirus type 16.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

A novel telomerase-specific gene therapy: gene transfer of caspase-8 utilizing the human telomerase catalytic subunit gene promoter

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

Telomerase activity in a specific cell subset co-expressing integrinbeta1/EGFR but not p75NGFR/bcl2/integrin beta4 in normal human epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

Telomerase is controlled by protein kinase Calpha in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

Telomerase activity reconstituted in vitro with purified human telomerase reverse transcriptase and human telomerase RNA component.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

Telomerase catalytic subunit homologs from fission yeast and human

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

Identification of Mad as a repressor of the human telomerase (hTERT) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

Telomerase activation by human papillomavirus type 16 E6 protein: induction of human telomerase reverse transcriptase expression through Myc and GC-rich Sp1 binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

Exogenous expression of p16INK4a is associated with decrease in telomerase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

A survey of telomerase activity in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

Effects of androgens on telomerase activity in normal and malignant prostate cells in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

Telomerase activation by histone deacetylase inhibitor in normal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

Expression of telomerase activity in human endometrium is localized to epithelial glandular cells and regulated in a menstrual phase-dependent manner correlated with cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

Transcriptional activation of the telomerase hTERT gene by human papillomavirus type 16 E6 oncoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

21 January 2018

Myc activates telomerase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

Origin of Concatemeric T7DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

Direct activation of TERT transcription by c-MYC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

An alternate splicing variant of the human telomerase catalytic subunit inhibits telomerase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

Cell cycle-dependent modulation of telomerase activity in tumor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

myc oncogenes: activation and amplification

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

7 January 2021

Telomere elongation in immortal human cells without detectable telomerase activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

7 January 2021

Inhibition of telomerase activity by cisplatin in human testicular cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

7 January 2021

Telomerase activity and survival of patients with node-positive breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

7 January 2021

Telomerase activity in human breast tumors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

7 January 2021

Correlating telomerase activity levels with human neuroblastoma outcomes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

7 January 2021

Overexpression of the p21 sdi1 gene induces senescence-like state in human cancer cells: implication for senescence-directed molecular therapy for cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

7 January 2021

Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

7 January 2021

Telomerase activity in cervical cancer is quantitatively distinct from that in its precursor lesions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

7 January 2021

Protein phosphatase 2A inhibits nuclear telomerase activity in human breast cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

7 January 2021

Cutting edge: telomerase activation in human T lymphocytes does not require increase in telomerase reverse transcriptase (hTERT) protein but is associated with hTERT phosphorylation and nuclear translocation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

7 January 2021

The Wilms' tumor 1 tumor suppressor gene represses transcription of the human telomerase reverse transcriptase gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

7 January 2021

Regulation of telomerase by alternate splicing of human telomerase reverse transcriptase (hTERT) in normal and neoplastic ovary, endometrium and myometrium

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

7 January 2021

Downregulation of telomerase reverse transcriptase mRNA expression by wild type p53 in human tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205163

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205163

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Dimensions Publication ID

2 August 2017

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1 reference