(Q34536074)

2 August 2017

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title

Pharmacokinetics of L-carnitine (English)

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2 August 2017

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Allan M Evans

1

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2 August 2017

Gianfranco Fornasini

series ordinal

2

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2 August 2017

publication date

1 January 2003

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Clinical Pharmacokinetics

2 August 2017

published in

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2 August 2017

volume

42

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2 August 2017

issue

11

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2 August 2017

page(s)

941-967

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Metabolic fate of dietary carnitine in human adults: identification and quantification of urinary and fecal metabolites

2 August 2017

cites work

1 reference

12 December 2020

Quantitation of Short- and Medium-Chain Acylcarnitines in Plasma by Radioisotopic Exchange/High-Performance Liquid Chromatography

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12 December 2020

Uptake of L-carnitine by a human intestinal epithelial cell line, Caco-2.

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12 December 2020

Studies of carnitine metabolism in relation to intestinal absorption

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12 December 2020

High-performance liquid chromatographic separation of acylcarnitines following derivatization with 4'-bromophenacyl trifluoromethanesulfonate

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12 December 2020

Thermospray liquid chromatography/mass spectrometry for the analysis of L-carnitine and its short-chain acyl derivatives

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12 December 2020

Quantitative assessment of carnitine loss during hemodialysis and hemofiltration

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12 December 2020

Diagnostic and therapeutic implications of medium-chain acylcarnitines in the medium-chain acyl-coA dehydrogenase deficiency.

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12 December 2020

An improved and simplified radioisotopic assay for the determination of free and esterified carnitine

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12 December 2020

Pharmacokinetics and safety of l-carnitine infused i.v. in healthy subjects

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12 December 2020

Zidovudine-induced mitochondrial myopathy is associated with muscle carnitine deficiency and lipid storage

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12 December 2020

Fish-odour syndrome and impaired N-oxidation.

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12 December 2020

Primary and secondary carnitine deficiency syndromes.

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12 December 2020

Discontinuous distribution of N-oxidation of dietary-derived trimethylamine in a British population

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12 December 2020

Detection of inborn errors of fatty acid oxidation from acylcarnitine analysis of plasma and blood spots with the radioisotopic exchange-high-performance liquid chromatographic method.

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12 December 2020

Evaluation of the effect of intravenous L-carnitine therapy on function, structure and fatty acid metabolism of skeletal muscle in patients receiving chronic hemodialysis

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12 December 2020

Fatty acid import into mitochondria

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12 December 2020

Measurement of L-carnitine and acylcarnitines in body fluids and tissues in children and in adults

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12 December 2020

Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2

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12 December 2020

Determination of L-carnitine, acetyl-L-carnitine and propionyl-L-carnitine in human plasma by high-performance liquid chromatography after pre-column derivatization with 1-aminoanthracene

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12 December 2020

Effect of carnitine and essential fatty acid supplementation on the uptake of 11C-carnitine in muscle of a myopathic carnitine-deficient patient using positron emission scintigraphy

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12 December 2020

Mutations in the organic cation/carnitine transporter OCTN2 in primary carnitine deficiency

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12 December 2020

Absorption of D- and L-carnitine by the intestine and kidney tubule in the rat.

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12 December 2020

Mutations of OCTN2, an organic cation/carnitine transporter, lead to deficient cellular carnitine uptake in primary carnitine deficiency

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12 December 2020

Carnitine metabolism and deficiency syndromes

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12 December 2020

Quantitative assay of free and total carnitine using tandem mass spectrometry

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12 December 2020

Determination of L-carnitine in biological fluids and tissues

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12 December 2020

The fish-odor syndrome

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12 December 2020

A radioisotopic-exchange method for quantitation of short-chain (acid-soluble) acylcarnitines

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12 December 2020

A comparison of plasma and muscle carnitine levels in patients on peritoneal or hemodialysis for chronic renal failure

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12 December 2020

Comparison ofL‐Carnitine Pharmacokinetics With and Without Baseline Correction Following Administration of Single 20–mglkg Intravenous Dose

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12 December 2020

Analysis of acylcarnitines in normal human urine with the radioisotopic exchange-high performance liquid chromatography (HPLC) method

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12 December 2020

Dietary carnitine effects on carnitine concentrations in urine and milk in lactating women

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12 December 2020

Microdetermination of (-)carnitine and carnitine acetyltransferase activity

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12 December 2020

Simple and unambiguous method for identifying urinary acylcarnitines using gas chromatography--mass spectrometry.

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12 December 2020

Perturbation of serum carnitine levels in human adults by chronic renal disease and dialysis therapy

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12 December 2020

Toxicity of aliphatic amines in uremia

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12 December 2020

Disposition of L-carnitine and its short-chain esters, acetyl-L-carnitine and propionyl-L-carnitine, in the rat isolated perfused liver

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12 December 2020

Multicenter trial of L-carnitine in maintenance hemodialysis patients. I. Carnitine concentrations and lipid effects

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12 December 2020

Carnitine concentrations in dialysed and undialysed patients with chronic renal insufficiency

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12 December 2020

Errors caused by the use of D,L-octanoylcarnitine for blood-spot calibrators

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12 December 2020

Radioisotopic assay of acetylcarnitine and acetyl-CoA

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12 December 2020

Biosynthesis and metabolism of carnitine

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12 December 2020

Carnitine biosynthesis in mammals

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12 December 2020

Pharmacokinetic considerations for the therapeutic use of carnitine in hemodialysis patients.

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12 December 2020

A simple radioisotopic assay of acetylcarnitine and acetyl-CoA at picomolar levels

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12 December 2020

Application of high resolution fast atom bombardment and constant B/E ratio linked scanning to the identification and analysis of acylcarnitines in metabolic disease

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12 December 2020

Carnitine deficiency induced during hemodialysis and hyperlipidemia: effect of replacement therapy

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12 December 2020

The measurement of carnitine and acyl-carnitines: application to the investigation of patients with suspected inherited disorders of mitochondrial fatty acid oxidation

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12 December 2020

Physiological mechanism-based analysis of dose-dependent gastrointestinal absorption of L-carnitine in rats.

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12 December 2020

Effect of L-carnitine and acetyl-L-carnitine on the human erythrocyte membrane stability and deformability

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12 December 2020

Carnitine transport in human intestinal biopsy specimens. Demonstration of an active transport system.

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12 December 2020

Carnitine decarboxylase. The conversion of carnitine to beta-methylcholine.

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12 December 2020

Newborn screening with tandem mass spectrometry: 12 months' experience in NSW Australia

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12 December 2020

Improved radiochemical assay for carnitine and its derivatives in plasma and tissue extracts

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12 December 2020

Renal handling of carnitine in secondary carnitine deficiency disorders

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12 December 2020

Multicenter trial of L-carnitine in maintenance hemodialysis patients. II. Clinical and biochemical effects

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12 December 2020

Radioisotopic assays of CoASH and carnitine and their acetylated forms in human skeletal muscle

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12 December 2020

In vivo studies of intestinal carnitine absorption in rats

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12 December 2020

Excretion of l-carnitine in man

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12 December 2020

Carnitine measurements in liver, muscle tissue, and blood in normal subjects.

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12 December 2020

Assay for free and total carnitine in human plasma using tandem mass spectrometry

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12 December 2020

Plasma and muscle carnitine levels in haemodialysis patients with morphological-ultrastructural examination of muscle samples

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12 December 2020

Quantification of carnitine, acetylcarnitine, and total carnitine in tissues by high-performance liquid chromatography: the effect of exercise on carnitine homeostasis in man

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12 December 2020

Diagnosis of isovaleric acidaemia by tandem mass spectrometry: false positive result due to pivaloylcarnitine in a newborn screening programme

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12 December 2020

Metabolism and toxicity of aliphatic amines

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12 December 2020

HPLC determination of carnitine and acylcarnitines in human plasma by means of fluorescence labeling using 2-(4-hydrazinocarbonylphenyl)-4,5-diphenylimidazole

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12 December 2020

Effect of L-carnitine supplementation on acute valproate intoxication

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12 December 2020

Quantification of carnitine and specific acylcarnitines by high-performance liquid chromatography: application to normal human urine and urine from patients with methylmalonic aciduria, isovaleric acidemia or medium-chain acyl-CoA dehydrogenase defi

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12 December 2020

The fish odour syndrome: biochemical, familial, and clinical aspects

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12 December 2020

A method for the determination of carnitine in the picomole range

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12 December 2020

Pharmacokinetics of propionyl-L-carnitine in humans: evidence for saturable tubular reabsorption

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12 December 2020

Carnitine: an osmolyte that plays a metabolic role

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12 December 2020

Carnitine metabolism and its regulation in microorganisms and mammals

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12 December 2020

Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter

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12 December 2020

Effect of deproteinization and reagent buffer on the enzymatic assay of L-carnitine in serum

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12 December 2020

Clinical and biochemical aspects of carnitine deficiency and insufficiency: transport defects and inborn errors of beta-oxidation

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12 December 2020

Trimethylaminuria associated with seizures and behavioural disturbance: a case report

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12 December 2020

Turnover of carnitine by rat tissues

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12 December 2020

Inaccurate measurement of free carnitine by the electrospray tandem mass spectrometry screening method for blood spots

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12 December 2020

Carnitine levels in human serum in health and disease

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12 December 2020

The therapeutic potential of carnitine in cardiovascular disorders

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12 December 2020

Plasma and urine pharmacokinetics of free and of short-chain carnitine after administration of carnitine in man

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12 December 2020

Determination of free carnitine and 'total' carnitine in human urine: derivatization with 4'-bromophenacyl trifluoromethanesulfonate and high performance liquid chromatography

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12 December 2020

Carnitine deficiency induced during intermittent haemodialysis for renal failure

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12 December 2020

Pharmacokinetics of bolus intravenous and oral doses of L-carnitine in healthy subjects.

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12 December 2020

Metabolism and excretion of carnitine and acylcarnitines in the perfused rat kidney

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12 December 2020

Partial muscle carnitine palmitoyltransferase-A deficiency. Rhabdomyolysis associated with transiently decreased muscle carnitine content after ibuprofen therapy

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12 December 2020

Improved methodology to assay carnitine and levels of free and total carnitine in human plasma

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12 December 2020

Sources of error in determinations of carnitine and acylcarnitine in plasma

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12 December 2020

Multiple‐Dose Pharmacokinetics and Bioequivalence L-Carnitine 330-mg Tablet versus 1-g Chewable Tablet versus Enteral Solution in Healthy Adult Male Volunteers

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12 December 2020

Effects of L-carnitine supplementation on muscular symptoms in hemodialyzed patients

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12 December 2020

Correlation between increased serum and tissue L-carnitine levels and improved muscle symptoms in hemodialyzed patients

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12 December 2020

Functional and pharmacological characterization of human Na(+)-carnitine cotransporter hOCTN2.

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12 December 2020

Deficient Muscle Carnitine Transport in Primary Carnitine Deficiency

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12 December 2020

Diagnosis of inborn errors of metabolism from blood spots by acylcarnitines and amino acids profiling using automated electrospray tandem mass spectrometry

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12 December 2020

Quantitative plasma acylcarnitine analysis using electrospray tandem mass spectrometry for the diagnosis of organic acidaemias and fatty acid oxidation defects

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12 December 2020

Rhythm of carnitine levels in serum and urine of normal subjects

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12 December 2020

Carnitine transport in rat small intestine

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12 December 2020

Use of anion-exchange resin in F- form in sample processing for determination of carnitine

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12 December 2020

Stable isotopes in clinical pharmacokinetic investigations. Advantages and disadvantages

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12 December 2020

Effect of diet on plasma carnitine levels and urinary carnitine excretion in humans

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12 December 2020

Dietary precursors of trimethylamine in man: a pilot study

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12 December 2020

Carnitine function and requirements during the life cycle

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12 December 2020

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12 December 2020

Pharmacokinetics of l-carnitine in man following intravenous infusion of dl-carnitine

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12 December 2020

Acetylation of Tris(hydroxymethyl)aminomethane (Tris) and Tris derivatives by carnitine acetyltransferase

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12 December 2020

beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter

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12 December 2020

Disclosure of the metabolic retroversion of trimethylamine N-oxide in humans: a pharmacogenetic approach

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12 December 2020

Kinetics of intravenously administered carnitine in haemodialysed children

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12 December 2020

The effect of enteral carnitine administration in humans

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12 December 2020

Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter

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12 December 2020

A sensitive enzymic assay for carnitine

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12 December 2020

Kinetic compartmental analysis of carnitine metabolism in the human carnitine deficiency syndromes. Evidence for alterations in tissue carnitine transport

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12 December 2020

The pharmacology of carnitine

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12 December 2020

Citrate interference with the determination of acetylcarnitine: a method for its elimination

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12 December 2020

Biochemical profile or uremic breath

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12 December 2020

ENZYMOLOGICAL DETERMINATION OF FREE CARNITINE CONCENTRATIONS IN RAT TISSUES

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12 December 2020

Differentiation of isomeric acylcarnitines using tandem mass spectrometry

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12 December 2020

Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2.

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12 December 2020

Disposition of L-carnitine and acetyl-L-carnitine in the isolated perfused rat kidney

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12 December 2020

Carnitine status of lactoovovegetarians and strict vegetarian adults and children

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12 December 2020

Uptake of l-carnitine, d-carnitine and acetyl-l-carnitine by isolated guinea-pig enterocytes

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12 December 2020

Concentration of carnitine in human muscle tissue.

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12 December 2020

Analysis of acylcarnitines as their N-demethylated ester derivatives by gas chromatography-chemical ionization mass spectrometry

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12 December 2020

The use of automated electrospray ionization tandem MS for the diagnosis of inborn errors of metabolism from dried blood spots

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12 December 2020

Correlation between plasma carnitine, muscle carnitine and glycogen levels in maintenance hemodialysis patients

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12 December 2020

Electrospray tandem mass spectrometry for analysis of acylcarnitines in dried postmortem blood specimens collected at autopsy from infants with unexplained cause of death.

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12 December 2020

Primary systemic carnitine deficiency. II. Renal handling of carnitine

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12 December 2020

Serum and tissue carnitine assay based on dialysis

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12 December 2020

Fractional absorption of L-carnitine after oral administration in rats: evaluation of absorption site and dose dependency

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12 December 2020

Carnitine metabolism in chronic renal failure

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12 December 2020

Renal adaptation to dietary carnitine in humans

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12 December 2020

Comments on quantitation of carnitine esters by high-performance liquid chromatography

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12 December 2020

Carnitine abnormalities in patients with renal insufficiency. Pathophysiological and therapeutical aspects

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12 December 2020

Application of continuous-flow liquid chromatography/fast-atom bombardment mass spectrometry to the analysis of diagnostic acylcarnitines in human urine

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12 December 2020

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12 December 2020

Carnitine deficiency associated with long-term pivampicillin treatment: the effect of a replacement therapy regime

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12 December 2020

Carnitine and carnitine esters in plasma and adipose tissue of chronic uremic patients undergoing hemodialysis.

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12 December 2020

Quantification of carnitine esters by high-performance liquid chromatography. Effect of feeding medium-chain triglycerides on the plasma carnitine ester profile

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12 December 2020

Effect of fasting on free and esterified carnitine levels in human serum and urine: Correlation with serum levels of free fatty acids and β-hydroxybutyrate

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12 December 2020

Determination of carnitine and saturated-acyl group carnitines in human urine by high-performance liquid chromatography with fluorescence detection

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12 December 2020

Quantification of free carnitine, individual short- and medium-chain acylcarnitines, and total carnitine in plasma by high-performance liquid chromatography

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12 December 2020

Carnitine and acetylcarnitine in red blood cells

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12 December 2020

Carnitine and its derivatives in cardiovascular disease

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12 December 2020

Carnitine kinetics during dialysis. Evidence of unilateral transport from tissues to plasma

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12 December 2020

Effect of L-carnitine treatment for valproate-induced hepatotoxicity

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12 December 2020

Quantitative estimation of absorption and degradation of a carnitine supplement by human adults

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12 December 2020

Absorption and excretion of L-carnitine during single or multiple dosings in humans

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12 December 2020

Properties of partially purified carnitine acetyltransferase

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12 December 2020

L-carnitine and acetyl-L-carnitine status during hemodialysis with acetate in humans: a kinetic analysis

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12 December 2020

Effects of pivalic acid-containing prodrugs on carnitine homeostasis and on response to fasting in children

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12 December 2020

A simple fluorometric method for the determination of serum free carnitine

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12 December 2020

Metabolism of labeled carnitine in the rat

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12 December 2020

L-Carnitine dissimilation in the gastrointestinal tract of the rat

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12 December 2020

Effect of intravenous L-carnitine on carnitine homeostasis and fuel metabolism during exercise in humans

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12 December 2020

Carnitine metabolism and function in humans

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12 December 2020

Plasma and muscle free carnitine deficiency due to renal Fanconi syndrome

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12 December 2020

Carnitine metabolism in the fasting rat

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12 December 2020

Spectrophotometry of carnitine in biological fluids and tissue with a Cobas Bio centrifugal analyzer

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12 December 2020

Carnitine metabolism in patients with chronic liver disease

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12 December 2020

Pharmacokinetics of L-carnitine in patients with end-stage renal disease undergoing long-term hemodialysis

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12 December 2020

Endogenous formation of dimethylamine

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12 December 2020

L-Carnitine: therapeutic applications of a conditionally-essential amino acid

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12 December 2020

Trimethylamine N-oxide as a probable source of urinary dimethylamine in man; a statistical approach

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12 December 2020

Effect of dietary macronutrient content on carnitine excretion and efficiency of carnitine reabsorption

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12 December 2020

Kinetic compartmental analysis of carnitine metabolism in the dog.

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12 December 2020

Automated tandem mass spectrometry for mass newborn screening for disorders in fatty acid, organic acid, and amino acid metabolism.

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12 December 2020

Trimethylaminuria: the fish-odour syndrome

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12 December 2020

Renal handling of free and acylcarnitine in secondary carnitine deficiency

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12 December 2020

Dimethylamine formation in man

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12 December 2020

Identification of urinary acylcarnitines using gas chromatography-mass spectrometry: preliminary clinical applications

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12 December 2020

10.2165/00003088-200342110-00002

Identifiers

DOI

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Dimensions Publication ID

2 August 2017

1007359994

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