(Q34540902)

2 August 2017

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title

Arresting developments in heptahelical receptor signaling and regulation (English)

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2 August 2017

2

Robert J Lefkowitz

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2 August 2017

Stephen J Perry

1

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2 August 2017

publication date

1 March 2002

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2 August 2017

published in

Trends in Cell Biology

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2 August 2017

volume

12

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2 August 2017

issue

3

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2 August 2017

page(s)

130-138

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Molecular tinkering of G protein-coupled receptors: an evolutionary success

2 August 2017

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7 January 2021

Model systems for the study of seven-transmembrane-segment receptors

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7 January 2021

G protein-coupled receptor kinases

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7 January 2021

The role of receptor kinases and arrestins in G protein-coupled receptor regulation

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7 January 2021

Deactivation of photoactivated rhodopsin by rhodopsin-kinase and arrestin

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7 January 2021

Phosphodiesterase activation by photoexcited rhodopsin is quenched when rhodopsin is phosphorylated and binds the intrinsic 48-kDa protein of rod outer segments

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7 January 2021

Inactivation of photoexcited rhodopsin in retinal rods: the roles of rhodopsin kinase and 48-kDa protein (arrestin)

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7 January 2021

A novel catecholamine-activated adenosine cyclic 3',5'-phosphate independent pathway for beta-adrenergic receptor phosphorylation in wild-type and mutant S49 lymphoma cells: mechanism of homologous desensitization of adenylate cyclase

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7 January 2021

Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor

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7 January 2021

Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein)

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7 January 2021

beta-Arrestin: a protein that regulates beta-adrenergic receptor function

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7 January 2021

A novel subtype of G-protein-coupled receptor kinase, GRK7, in teleost cone photoreceptors

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7 January 2021

The arrestin superfamily: cone arrestins are a fourth family

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7 January 2021

Synergistic regulation of m2 muscarinic acetylcholine receptor desensitization and sequestration by G protein-coupled receptor kinase-2 and beta-arrestin-1

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7 January 2021

Phosphorylation and desensitization of the human beta 1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase

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7 January 2021

Effect of different G protein-coupled receptor kinases on phosphorylation and desensitization of the alpha1B-adrenergic receptor

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7 January 2021

beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking

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7 January 2021

beta -Arrestins regulate protease-activated receptor-1 desensitization but not internalization or Down-regulation

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7 January 2021

Enhanced morphine analgesia in mice lacking beta-arrestin 2

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7 January 2021

Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence

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7 January 2021

Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization

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7 January 2021

The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis

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7 January 2021

The interaction of beta-arrestin with the AP-2 adaptor is required for the clustering of beta 2-adrenergic receptor into clathrin-coated pits

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7 January 2021

Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor

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7 January 2021

Arrestin/clathrin interaction. Localization of the arrestin binding locus to the clathrin terminal domain

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7 January 2021

Arrestin/clathrin interaction. Localization of the clathrin binding domain of nonvisual arrestins to the carboxy terminus

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7 January 2021

beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor

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7 January 2021

Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors

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7 January 2021

beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis

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7 January 2021

The ADP ribosylation factor nucleotide exchange factor ARNO promotes beta-arrestin release necessary for luteinizing hormone/choriogonadotropin receptor desensitization

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7 January 2021

Arf proteins: the membrane traffic police?

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7 January 2021

Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity

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7 January 2021

beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein

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7 January 2021

Feedback regulation of beta-arrestin1 function by extracellular signal-regulated kinases

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7 January 2021

Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin

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7 January 2021

A large PEST-like sequence directs the ubiquitination, endocytosis, and vacuolar degradation of the yeast a-factor receptor

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7 January 2021

Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis

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7 January 2021

Association of beta-arrestin with G protein-coupled receptors during clathrin-mediated endocytosis dictates the profile of receptor resensitization

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7 January 2021

Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*

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7 January 2021

Identification of NSF as a beta-arrestin1-binding protein. Implications for beta2-adrenergic receptor regulation

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7 January 2021

Mechanisms of synaptic vesicle exocytosis

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7 January 2021

Signalling by the p60c-src family of protein-tyrosine kinases

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7 January 2021

The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades

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7 January 2021

Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes

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7 January 2021

The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor

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7 January 2021

beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis

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7 January 2021

Regulation of tyrosine kinase activation and granule release through beta-arrestin by CXCRI

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7 January 2021

beta -Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transport

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7 January 2021

Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human

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7 January 2021

Organization and regulation of mitogen-activated protein kinase signaling pathways

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7 January 2021

Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3

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7 January 2021

beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2

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7 January 2021

Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds

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7 January 2021

The proliferative and antiapoptotic effects of substance P are facilitated by formation of a beta -arrestin-dependent scaffolding complex

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7 January 2021

A molecular pathway for light-dependent photoreceptor apoptosis in Drosophila.

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7 January 2021

The formation of stable rhodopsin-arrestin complexes induces apoptosis and photoreceptor cell degeneration.

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7 January 2021

A role for the light-dependent phosphorylation of visual arrestin

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7 January 2021

Constitutive arrestin-mediated desensitization of a human vasopressin receptor mutant associated with nephrogenic diabetes insipidus

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7 January 2021

Turned on to ill effect

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7 January 2021

10.1016/S0962-8924(01)02239-5

Identifiers

DOI

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2 August 2017

1 reference