(Q34543759)

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PBOX-15, a novel microtubule targeting agent, induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple myeloma cells

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21179037%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

PBOX-15, a novel microtubule targeting agent, induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple myeloma cells (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21179037%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

multiple myeloma

1 reference

based on heuristic

inferred from title

apoptotic process

1 reference

based on heuristic

inferred from title

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21179037%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Elisabeth Vandenberghe

4

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21179037%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Stefania Butini

10

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Europe PubMed Central

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18 January 2020

Daniela M Zisterer

12

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21179037%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Anthony Mcelligott

14

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18 January 2020

author name string

E N Maginn

1

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18 January 2020

P Hayden

3

1 reference

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18 January 2020

B MacDonagh

5

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18 January 2020

P Evans

6

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18 January 2020

M Goodyer

7

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18 January 2020

P Tewari

8

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18 January 2020

G Campiani

9

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18 January 2020

D C Williams

11

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18 January 2020

M P Lawler

13

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18 January 2020

language of work or name

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publication date

21 December 2010

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18 January 2020

British Journal of Cancer

1 reference

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18 January 2020

104

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18 January 2020

2

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Europe PubMed Central

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18 January 2020

281-289

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18 January 2020

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3031893/fullTextXML

based on heuristic

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Novel pyrrolo-1,5-benzoxazepine compounds display significant activity against resistant chronic myeloid leukaemia cells in vitro, in ex vivo patient samples and in vivo.

1 reference

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7 July 2018

Exploiting the mevalonate pathway to distinguish statin-sensitive multiple myeloma

1 reference

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7 July 2018

Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce apoptosis in multi-drug-resistant cancer cells

1 reference

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7 July 2018

BH3-only proteins in apoptosis and beyond: an overview

1 reference

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7 July 2018

Perifosine synergistically enhances TRAIL-induced myeloma cell apoptosis via up-regulation of death receptors

1 reference

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7 July 2018

Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs.

1 reference

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7 July 2018

New tubulin polymerization inhibitor derived from thalidomide: implications for anti-myeloma therapy

1 reference

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7 July 2018

BH3-only proteins Noxa, Bmf, and Bim are necessary for arsenic trioxide-induced cell death in myeloma

1 reference

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7 July 2018

Multiple myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031893

7 July 2018

A new microtubule-targeting compound PBOX-15 inhibits T-cell migration via post-translational modifications of tubulin

1 reference

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7 July 2018

Clinical pharmacology and use of microtubule-targeting agents in cancer therapy.

1 reference

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7 July 2018

Genomic aberrations and immunohistochemical markers as prognostic indicators in multiple myeloma

1 reference

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7 July 2018

Role of genetics in prognostication in myeloma

1 reference

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7 July 2018

BubR1 is required for a sustained mitotic spindle checkpoint arrest in human cancer cells treated with tubulin-targeting pyrrolo-1,5-benzoxazepines.

1 reference

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7 July 2018

Mechanism of apoptosis induced by IFN-alpha in human myeloma cells: role of Jak1 and Bim and potentiation by rapamycin.

1 reference

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7 July 2018

ABCG2 expression, function, and promoter methylation in human multiple myeloma

1 reference

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7 July 2018

A novel isocoumarin derivative induces mitotic phase arrest and apoptosis of human multiple myeloma cells

1 reference

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7 July 2018

Identification of tubulin as the molecular target of proapoptotic pyrrolo-1,5-benzoxazepines

1 reference

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7 July 2018

BAFF regulates B cell survival by downregulating the BH3-only family member Bim via the ERK pathway

1 reference

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7 July 2018

Pyrrolo[1,5]benzoxa(thia)zepines as a new class of potent apoptotic agents. Biological studies and identification of an intracellular location of their drug target

1 reference

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7 July 2018

The imbalance between Bim and Mcl-1 expression controls the survival of human myeloma cells

1 reference

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7 July 2018

2-MeOE2bisMATE induces caspase-dependent apoptosis in CAL51 breast cancer cells and overcomes resistance to TRAIL via cooperative activation of caspases

1 reference

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7 July 2018

Microtubules as a target for anticancer drugs

1 reference

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7 July 2018

Caspase cleavage of BimEL triggers a positive feedback amplification of apoptotic signaling

1 reference

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7 July 2018

2-methoxyestradiol up-regulates death receptor 5 and induces apoptosis through activation of the extrinsic pathway

1 reference

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7 July 2018

Arsenic trioxide-induced apoptosis in myeloma cells: p53-dependent G1 or G2/M cell cycle arrest, activation of caspase-8 or caspase-9, and synergy with APO2/TRAIL.

1 reference

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Adriamycin sensitizes the adriamycin-resistant 8226/Dox40 human multiple myeloma cells to Apo2L/tumor necrosis factor-related apoptosis-inducing ligand-mediated (TRAIL) apoptosis.

1 reference

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Pyrrolo-1,5-benzoxazepines induce apoptosis in chronic myelogenous leukemia (CML) cells by bypassing the apoptotic suppressor bcr-abl.

1 reference

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Pyrrolo-1,5-benzoxazepines induce apoptosis in HL-60, Jurkat, and Hut-78 cells: a new class of apoptotic agents.

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Establishment of five human myeloma cell lines

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VAD-based regimens as primary treatment for multiple myeloma

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Trichostatin A sensitizes TRAIL-resistant myeloma cells by downregulation of the antiapoptotic Bcl-2 proteins

1 reference

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The myeloma cell antigen syndecan-1 is lost by apoptotic myeloma cells

1 reference

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Early genetic events provide the basis for a clinical classification of multiple myeloma.

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The novel tubulin-targeting agent pyrrolo-1,5-benzoxazepine-15 induces apoptosis in poor prognostic subgroups of chronic lymphocytic leukemia

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Selective induction of apoptosis by the pyrrolo-1,5-benzoxazepine 7-[[dimethylcarbamoyl]oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine (PBOX-6) in Leukemia cells occurs via the c-Jun NH2-terminal kinase-dependent phosphorylation and inactiva

1 reference

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TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: therapeutic applications

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Effect of vinorelbine on the growth of human myeloma cell lines in vitro

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No evidence of mutations of the PSMB5 (beta-5 subunit of proteasome) in a case of myeloma with clinical resistance to Bortezomib

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Combined pegylated liposomal doxorubicin and bortezomib is highly effective in patients with recurrent or refractory multiple myeloma who received prior thalidomide/lenalidomide therapy

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Sulindac sulfide-induced apoptosis involves death receptor 5 and the caspase 8-dependent pathway in human colon and prostate cancer cells.

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P-glycoprotein expression in human plasma cell myeloma: correlation with prior chemotherapy.

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Interleukin 6 differentially potentiates the antitumor effects of taxol and vinblastine in U266 human myeloma cells

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Melphalan-induced apoptosis in multiple myeloma cells is associated with a cleavage of Mcl-1 and Bim and a decrease in the Mcl-1/Bim complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/21179037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

First clinical experience with simvastatin to overcome drug resistance in refractory multiple myeloma

1 reference

https://pubmed.ncbi.nlm.nih.gov/21179037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/SJ.BJC.6606035

1 reference

Europe PubMed Central

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18 January 2020

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Europe PubMed Central

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18 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21179037%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

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