(Q34543815)

2 August 2017

Single agent and combination studies of pralatrexate and molecular correlates of sensitivity (English)

1 reference

2 August 2017

1 reference

ChEBI release 2020-05-28

M Serova

1

1 reference

2 August 2017

I Bieche

2

1 reference

2 August 2017

M-P Sablin

3

1 reference

2 August 2017

G J Pronk

4

1 reference

2 August 2017

M Vidaud

5

1 reference

2 August 2017

E Cvitkovic

6

1 reference

2 August 2017

S Faivre

7

1 reference

2 August 2017

E Raymond

8

1 reference

2 August 2017

language of work or name

English

0 references

publication date

21 December 2010

1 reference

British Journal of Cancer

2 August 2017

1 reference

2 August 2017

104

1 reference

2 August 2017

2

1 reference

2 August 2017

272-280

1 reference

https://scigraph.springernature.com/pub.10.1038/sj.bjc.6606063

2 August 2017

0 references

cites work

Gene expression profiling of leukemia T-cells resistant to methotrexate and 7-hydroxymethotrexate reveals alterations that preserve intracellular levels of folate and nucleotide biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031902

Pralatrexate-induced tumor cell apoptosis in the epidermis of a patient with HTLV-1 adult T-cell lymphoma/leukemia causing skin erosions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031902

Distinct mechanistic activity profile of pralatrexate in comparison to other antifolates in in vitro and in vivo models of human cancers

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031902

Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031902

Molecular basis of antifolate resistance

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031902

Impaired CREB-1 phosphorylation in antifolate-resistant cell lines with down-regulation of the reduced folate carrier gene

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031902

Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031902

Altered gene expression of folate enzymes in adjacent mucosa is associated with outcome of colorectal cancer patients.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031902

Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031902

Open, randomized, multicenter trial of raltitrexed versus fluorouracil plus high-dose leucovorin in patients with advanced colorectal cancer. Tomudex Colorectal Cancer Study Group.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031902

Dihydrofolate reductase binding and cellular uptake of nonpolyglutamatable antifolates: correlates of cytotoxicity toward methotrexate-sensitive and -resistant human head and neck squamous carcinoma cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031902

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031902

Polyglutamation of methotrexate. Is methotrexate a prodrug?

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031902

Compartmentation of folate-mediated one-carbon metabolism in eukaryotes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031902

A phase 1 study of pralatrexate in combination with paclitaxel or docetaxel in patients with advanced solid tumors.

7 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6606063

Quantification of estrogen receptor alpha and beta expression in sporadic breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6606063

Synthesis and antitumor activity of 10-propargyl-10-deazaaminopterin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6606063

Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6606063

Reduced folate carrier protein expression in osteosarcoma: implications for the prediction of tumor chemosensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6606063

Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6606063

Pralatrexate, a novel class of antifol with high affinity for the reduced folate carrier-type 1, produces marked complete and durable remissions in a diversity of chemotherapy refractory cases of T-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6606063

The schedule-dependent effects of the novel antifolate pralatrexate and gemcitabine are superior to methotrexate and cytarabine in models of human non-Hodgkin's lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6606063

Activity of a novel anti-folate (PDX, 10-propargyl 10-deazaaminopterin) against human lymphoma is superior to methotrexate and correlates with tumor RFC-1 gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6606063

A new analogue of 10-deazaaminopterin with markedly enhanced curative effects against human tumor xenografts in mice

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21179031

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The role of impaired transport in (pre)clinical resistance to methotrexate: insights on new antifolates

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21179031

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/SJ.BJC.6606063

1 reference

Dimensions Publication ID

2 August 2017

0 references

1 reference

2 August 2017

1 reference