(Q43883948)

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Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis.

scientific article published in January 2002

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11841783%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis (English)

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7 December 2019

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based on heuristic

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based on heuristic

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Yehuda G Assaraf

4

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Europe PubMed Central

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7 December 2019

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Robert Mauritz

1

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7 December 2019

Godefridus J Peters

2

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7 December 2019

David G Priest

3

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7 December 2019

Stavit Drori

5

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7 December 2019

Ietje Kathmann

6

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7 December 2019

Paul Noordhuis

7

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7 December 2019

Marlene A Bunni

8

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7 December 2019

Andre Rosowsky

9

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7 December 2019

Jan H Schornagel

10

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7 December 2019

Herbert M Pinedo

11

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7 December 2019

Gerrit Jansen

12

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7 December 2019

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1 January 2002

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7 December 2019

Biochemical Pharmacology

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7 December 2019

63

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7 December 2019

2

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7 December 2019

105-115

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7 December 2019

Karnofsky memorial lecture. Ode to methotrexate

1 reference

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7 January 2021

The clinical pharmacology of methotrexate

1 reference

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7 January 2021

Intrinsic and acquired resistance to methotrexate in acute leukemia.

1 reference

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7 January 2021

Acquired methotrexate resistance in lymphoblasts resulting from altered kinetic properties of dihydrofoltate reductase

1 reference

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7 January 2021

Resistance to methotrexate due to gene amplification in a patient with acute leukemia

1 reference

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7 January 2021

The role of impaired transport in (pre)clinical resistance to methotrexate: insights on new antifolates

1 reference

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7 January 2021

MRP3, an organic anion transporter able to transport anti-cancer drugs

1 reference

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7 January 2021

Lack of functional retinoblastoma protein mediates increased resistance to antimetabolites in human sarcoma cell lines.

1 reference

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7 January 2021

Open, randomized, multicenter trial of raltitrexed versus fluorouracil plus high-dose leucovorin in patients with advanced colorectal cancer. Tomudex Colorectal Cancer Study Group.

1 reference

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7 January 2021

Clinical studies with MTA.

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900824-3

7 January 2021

Efficient utilization of the reduced folate carrier in CCRF-CEM human leukemic lymphoblasts by the potent antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L- ornithine (PT523) and its B-ring analogues

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900824-3

7 January 2021

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

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7 January 2021

Importance of pharmacodynamics in the in vitro antiproliferative activity of the antifolates methotrexate and 10-ethyl-10-deazaaminopterin against human head and neck squamous cell carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900824-3

7 January 2021

Loss of folic acid exporter function with markedly augmented folate accumulation in lipophilic antifolate-resistant mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900824-3

7 January 2021

A filter assay for thymidylate synthetase using 5-fluoro-2'-deoxyuridylate as an active site titrant.

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900824-3

7 January 2021

Impact of dietary folic acid on reduced folates in mouse plasma and tissues. Relationship to dideazatetrahydrofolate sensitivity

1 reference

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7 January 2021

Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines

1 reference

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7 January 2021

Mechanisms of resistance to N-[5-[N-(3, 4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino]-2-thenoyl]-L-glutamic acid (ZD1694), a folate-based thymidylate synthase inhibitor, in the HCT-8 human ileocecal adenocarcinoma cell line

1 reference

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7 January 2021

Cellular pharmacokinetics of ZD1694 in cultured human leukaemia cells sensitive, or made resistant, to this drug

1 reference

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7 January 2021

The influence of drug-exposure conditions on the development of resistance to methotrexate or ZD1694 in cultured human leukaemia cells

1 reference

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7 January 2021

Molecular characterisation of two cell lines selected for resistance to the folate-based thymidylate synthase inhibitor, ZD1694.

1 reference

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7 January 2021

Identification of three key active site residues in the C-terminal domain of human recombinant folylpoly-gamma-glutamate synthetase by site-directed mutagenesis

1 reference

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7 January 2021

Molecular analysis of murine leukemia cell lines resistant to 5, 10-dideazatetrahydrofolate identifies several amino acids critical to the function of folylpolyglutamate synthetase

1 reference

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7 January 2021

Resistance to tomudex (ZD1694): multifactorial in human breast and colon carcinoma cell lines

1 reference

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7 January 2021

Altered transport of folic acid and antifolates through the carrier mediated reduced folate transport system in a human leukemia cell line resistant to (6R) 5,10-dideazatetrahydrofolic acid (DDATHF).

1 reference

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7 January 2021

Molecular characterization of human acute leukemia cell line resistant to ZD9331, a non-polyglutamatable thymidylate synthase inhibitor

1 reference

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7 January 2021

A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance.

1 reference

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7 January 2021

Clustering of mutations in the first transmembrane domain of the human reduced folate carrier in GW1843U89-resistant leukemia cells with impaired antifolate transport and augmented folate uptake.

1 reference

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7 January 2021

Mutations in the reduced folate carrier gene which confer dominant resistance to 5,10-dideazatetrahydrofolate

1 reference

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7 January 2021

Pattern of mutations that results in loss of reduced folate carrier function under antifolate selective pressure augmented by chemical mutagenesis

1 reference

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7 January 2021

Cellular folates prevent polyglutamation of 5, 10-dideazatetrahydrofolate. A novel mechanism of resistance to folate antimetabolites

1 reference

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7 January 2021

Identifiers

10.1016/S0006-2952(01)00824-3

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11841783%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11841783%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

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