(Q46728526)

24 December 2017

title

Cellular folates prevent polyglutamation of 5, 10-dideazatetrahydrofolate. A novel mechanism of resistance to folate antimetabolites (English)

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24 December 2017

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Tse A

1

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24 December 2017

Moran RG

series ordinal

2

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24 December 2017

language of work or name

English

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publication date

1 October 1998

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24 December 2017

Journal of Biological Chemistry

published in

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24 December 2017

volume

273

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24 December 2017

issue

40

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24 December 2017

page(s)

25944-25952

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24 December 2017

Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25944

A dideazatetrahydrofolate analogue lacking a chiral center at C-6, N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5- yl)ethyl]benzoyl]-L-glutamic acid, is an inhibitor of thymidylate synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25944

Tight binding of folate substrates and inhibitors to recombinant mouse glycinamide ribonucleotide formyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25944

Structural features of 5,10-dideaza-5,6,7,8-tetrahydrofolate that determine inhibition of mammalian glycinamide ribonucleotide formyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25944

Thymidylate synthase inhibitors: the in vitro activity of a series of heterocyclic benzoyl ring modified 2-desamino-2-methyl-N10-substituted-5,8-dideazafolates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25944

Phase I study of (6R)-5,10-dideazatetrahydrofolate: a folate antimetabolite inhibitory to de novo purine synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25944

Determinants of the disparate antitumor activities of (6R)-5,10-dideaza-5,6,7,8-tetrahydrofolate and methotrexate toward human lymphoblastic leukemia cells, characterized by severely impaired antifolate membrane transport.

21 January 2018

1 reference

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Biochemical determinants of tumor sensitivity to 5-fluorouracil: Ultrasensitive methods for the determination of 5-fluoro-2′-deoxyuridylate, 2′-deoxyuridylate, and thymidylate synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25944

A microassay for mammalian folylpolyglutamate synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25944

Measurement of folylpolyglutamate synthetase in mammalian tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25944

A radioenzymatic method for the determination of tissue 10-formyltetrahydrofolate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25944

Mouse cDNAs encoding a trifunctional protein of de novo purine synthesis and a related single-domain glycinamide ribonucleotide synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25944

Loss of Folic Acid Exporter Function with Markedly Augmented Folate Accumulation in Lipophilic Antifolate-resistant Mammalian Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25944

Analysis of a mouse gene encoding three steps of purine synthesis reveals use of an intronic polyadenylation signal without alternative exon usage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25944

Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25944

Cytotoxicity of 5-fluoro-2'-deoxyuridine: requirement for reduced folate cofactors and antagonism by methotrexate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25944

Mutations in the reduced folate carrier gene which confer dominant resistance to 5,10-dideazatetrahydrofolate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25944

Final results of a randomised trial comparing 'Tomudex' (raltitrexed) with 5-fluorouracil plus leucovorin in advanced colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25944

Initial phase I evaluation of the novel thymidylate synthase inhibitor, LY231514, using the modified continual reassessment method for dose escalation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25944

On the cofactor specificity of glycinamide ribonucleotide and 5-aminoimidazole-4-carboxamide ribonucleotide transformylase from chicken liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25944

Impact of dietary folic acid on reduced folates in mouse plasma and tissues. Relationship to dideazatetrahydrofolate sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25944

Carrier-mediated transport of folate compounds in L1210 cells. Initial rate kinetics and extent of duality of entry routes for folic acid and diastereomers of 5-methyltetrahydrohomofolate in the presence of physiological anions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25944

A simple procedure for the synthesis of high specific activity tritiated (6S)-5-formyltetrahydrofolate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25944

Mammalian folyl polyglutamate synthetase: partial purification and properties of the mouse liver enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25944

Mammalian folylpoly-gamma-glutamate synthetase. 2. Substrate specificity and kinetic properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25944

21 January 2018

Identifiers

DOI

10.1074/JBC.273.40.25944

1 reference

24 December 2017

1 reference

24 December 2017