(Q36080916)

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Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines (English)

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

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author name string

Jackman AL

1

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Kelland LR

2

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Kimbell R

3

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Brown M

4

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Gibson W

5

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Aherne GW

6

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Hardcastle A

7

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Boyle FT

8

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

language of work or name

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publication date

1 May 1995

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

British Journal of Cancer

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

71

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

5

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

914-924

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

describes a project that uses

0 references

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https://scigraph.springernature.com/pub.10.1038/bjc.1995.178

0 references

Thymidylate Synthetase Overproduction in 5-Fluorodeoxyuridine-Resistant Mouse Fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

2 October 2017

Intracellular pharmacokinetics of methotrexate polyglutamates in human breast cancer cells. Selective retention and less dissociable binding of 4-NH2-10-CH3-pteroylglutamate4 and 4-NH2-10-CH3-pteroylglutamate5 to dihydrofolate reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

2 October 2017

A phase I evaluation of the quinazoline antifolate thymidylate synthase inhibitor, N10-propargyl-5,8-dideazafolic acid, CB3717

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

2 October 2017

Increased thymidylate synthase in L1210 cells possessing acquired resistance to N10-propargyl-5,8-dideazafolic acid (CB3717): development, characterization, and cross-resistance studies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

2 October 2017

Biological properties of ten human ovarian carcinoma cell lines: calibration in vitro against four platinum complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

2 October 2017

Polyglutamation of methotrexate. Is methotrexate a prodrug?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

2 October 2017

Thymidylate synthase inhibitors: the in vitro activity of a series of heterocyclic benzoyl ring modified 2-desamino-2-methyl-N10-substituted-5,8-dideazafolates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

2 October 2017

Experimental chemotherapy of neuroblastoma. II. Increased thymidylate synthetase activity in a 5-fluorodeoxyuridine-resistant variant of mouse neuroblastoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

2 October 2017

Altered transport of folic acid and antifolates through the carrier mediated reduced folate transport system in a human leukemia cell line resistant to (6R) 5,10-dideazatetrahydrofolic acid (DDATHF).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

11 July 2018

The measurement of polyglutamate metabolites of the thymidylate synthase inhibitor, ICI D1694, in mouse and human cultured cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

11 July 2018

Increased activity of gamma-glutamyl hydrolase in human sarcoma cell lines: a novel mechanism of intrinsic resistance to methotrexate (MTX).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

11 July 2018

A methotrexate-resistant human breast cancer cell line with multiple defects, including diminished formation of methotrexate polyglutamates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

11 July 2018

Isolation and biochemical characterization of folate deficient mutants of chinese hamster cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

11 July 2018

Thymidylate synthase gene amplification in a colon tumor resistant to fluoropyrimidine chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

11 July 2018

Thymidylate synthase gene amplification in fluorodeoxyuridine-resistant mouse cell lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

11 July 2018

Thymidylate synthase overproduction and gene amplification in fluorodeoxyuridine-resistant human cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

11 July 2018

Activity of thymidylate synthetase and its inhibition by 5-fluorouracil in highly enzyme-overproducing cells resistant to 10-propargyl-5,8-dideazafolate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

11 July 2018

Inherent resistance of human squamous carcinoma cell lines to methotrexate as a result of decreased polyglutamylation of this drug.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

11 July 2018

Impaired polyglutamylation of methotrexate as a cause of resistance in CCRF-CEM cells after short-term, high-dose treatment with this drug

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

11 July 2018

Activity of the thymidylate synthase inhibitor 2-desamino-N10-propargyl-5,8-dideazafolic acid and related compounds in murine (L1210) and human (W1L2) systems in vitro and in L1210 in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

11 July 2018

Mechanism of cell death following thymidylate synthase inhibition: 2'-deoxyuridine-5'-triphosphate accumulation, DNA damage, and growth inhibition following exposure to CB3717 and dipyridamole

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

11 July 2018

Decreased folylpolyglutamate synthetase activity as a mechanism of methotrexate resistance in CCRF-CEM human leukemia sublines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

11 July 2018

ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

11 July 2018

Mechanisms of acquired resistance to methotrexate in a human squamous carcinoma cell line of the head and neck, exposed to different treatment schedules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

11 July 2018

The biochemical pharmacology of the thymidylate synthase inhibitor, 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

11 July 2018

Human lymphoblastoid cells with acquired resistance to C2-desamino-C2-methyl-N10-propargyl-5,8-dideazafolic acid: a novel folate-based thymidylate synthase inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

11 July 2018

Enzyme studies of methotrexate-resistant human leukemic cell (K562) subclones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

11 July 2018

Characterization of the coexisting multiple mechanisms of methotrexate resistance in mouse 3T6 R50 fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

11 July 2018

Design of thymidylate synthase inhibitors using protein crystal structures: the synthesis and biological evaluation of a novel class of 5-substituted quinazolinones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

23 September 2018

A strategy for the design of membrane-permeable folypoly-gamma-glutamate synthetase inhibitors: "bay-region"-substituted 2-desamino-2-methyl-5,8-dideazafolate analogs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

23 September 2018

Acquisition of resistance to antifolates caused by enhanced gamma-glutamyl hydrolase activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

23 September 2018

Human thymidylate synthetase--III. Effects of methotrexate and folate analogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for the cytotoxic activity of polyglutamate derivatives of methotrexate

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased thymidylate synthetase in 5-fluorodeoxyuridine resistant cultured hepatoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A potent antitumour quinazoline inhibitor of thymidylate synthetase: Synthesis, biological properties and therapeutic results in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transport of the antitumor antibiotic Cl-920 into L1210 leukemia cells by the reduced folate carrier system

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydrolytic cleavage of methotrexate gamma-polyglutamates by folylpolyglutamyl hydrolase derived from various tumors and normal tissues of the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of thymidylate synthase gene amplification and of mRNA levels in the cell cycle

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation and retention and biological activity of N10-propargyl-5,8-dideazafolic acid (CB3717) polyglutamates in L1210 cells in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quinazoline antifolates inhibiting thymidylate synthase: 2-desamino derivatives with enhanced solubility and potency

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The quantitation by radioimmunoassay of 2′-deoxyuridine 5′-triphosphate in extracts of thymidylate synthase-inhibited cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C2 position

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple membrane transport systems for the uptake of folate-based thymidylate synthase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quinazoline antifolate thymidylate synthase inhibitors: heterocyclic benzoyl ring modifications

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic characteristics of ICI D1694: a quinazoline antifolate which inhibits thymidylate synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical and cellular pharmacology of 1843U89, a novel benzoquinazoline inhibitor of thymidylate synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gamma-linked dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8- dideazafolate as antitumour agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substituted-2-desamino-2-methyl-quinazolinones. A series of novel antitumour agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quinazoline antifolates inhibiting thymidylate synthase: synthesis of gamma-linked peptide and amide analogues of 2-desamino-2-methyl-N10-propargyl- 5,8-dideazafolic acid (ICI 198583)

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/BJC.1995.178

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

ResearchGate publication ID

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