(Q54118067)

English

A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance.

scientific article published in November 1998

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scholarly article

1 reference

Europe PubMed Central

25 May 2018

http://europepmc.org/abstract/MED/9804775

A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance. (English)

1 reference

Europe PubMed Central

25 May 2018

http://europepmc.org/abstract/MED/9804775

1 reference

based on heuristic

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author name string

Jansen G

1

1 reference

Europe PubMed Central

25 May 2018

http://europepmc.org/abstract/MED/9804775

Mauritz R

2

1 reference

Europe PubMed Central

25 May 2018

http://europepmc.org/abstract/MED/9804775

Drori S

3

1 reference

Europe PubMed Central

25 May 2018

http://europepmc.org/abstract/MED/9804775

Sprecher H

4

1 reference

Europe PubMed Central

25 May 2018

http://europepmc.org/abstract/MED/9804775

Kathmann I

5

1 reference

Europe PubMed Central

25 May 2018

http://europepmc.org/abstract/MED/9804775

Bunni M

6

1 reference

Europe PubMed Central

25 May 2018

http://europepmc.org/abstract/MED/9804775

Priest DG

7

1 reference

Europe PubMed Central

25 May 2018

http://europepmc.org/abstract/MED/9804775

Noordhuis P

8

1 reference

Europe PubMed Central

25 May 2018

http://europepmc.org/abstract/MED/9804775

Schornagel JH

9

1 reference

Europe PubMed Central

25 May 2018

http://europepmc.org/abstract/MED/9804775

Pinedo HM

10

1 reference

Europe PubMed Central

25 May 2018

http://europepmc.org/abstract/MED/9804775

Peters GJ

11

1 reference

Europe PubMed Central

25 May 2018

http://europepmc.org/abstract/MED/9804775

Assaraf YG

12

1 reference

Europe PubMed Central

25 May 2018

http://europepmc.org/abstract/MED/9804775

language of work or name

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publication date

1 November 1998

1 reference

Europe PubMed Central

25 May 2018

http://europepmc.org/abstract/MED/9804775

Journal of Biological Chemistry

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Europe PubMed Central

25 May 2018

http://europepmc.org/abstract/MED/9804775

273

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Europe PubMed Central

25 May 2018

http://europepmc.org/abstract/MED/9804775

30189-30198

1 reference

Europe PubMed Central

25 May 2018

http://europepmc.org/abstract/MED/9804775

46

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Europe PubMed Central

25 May 2018

http://europepmc.org/abstract/MED/9804775

The cellular pharmacology of methotrexate

1 reference

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21 January 2018

Karnofsky memorial lecture. Ode to methotrexate

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21 January 2018

Intrinsic and acquired resistance to methotrexate in acute leukemia.

1 reference

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Molecular events in the membrane transport of methotrexate in human CCRF-CEM leukemia cell lines

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21 January 2018

Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective Chinese hamster ovary cells

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21 January 2018

Molecular cloning of the human placental folate transporter

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21 January 2018

Isolation of a human cDNA that complements a mutant hamster cell defective in methotrexate uptake

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21 January 2018

Gene amplification and increased expression of the reduced folate carrier in transport elevated K562 cells

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Identification of methotrexate transport deficiency in mammalian cells using fluoresceinated methotrexate and flow cytometry

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A reduced folate carrier mutation produces substrate-dependent alterations in carrier mobility in murine leukemia cells and methotrexate resistance with conservation of growth in 5-formyltetrahydrofolate

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21 January 2018

Characterization of a mutation in the reduced folate carrier in a transport defective L1210 murine leukemia cell line

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A single amino acid difference within the folate transporter encoded by the murine RFC-1 gene selectively alters its interaction with folate analogues. Implications for intrinsic antifolate resistance and directional orientation of the transporter w

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Clinical Science Review: Update on Trimetrexate, a Folate Antagonist with Antineoplastic and Antiprotozoal Properties

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Folate-based thymidylate synthase inhibitors as anticancer drugs

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AG2034: a novel inhibitor of glycinamide ribonucleotide formyltransferase

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21 January 2018

Effects of methotrexate esters and other lipophilic antifolates on methotrexate-resistant human leukemic lymphoblasts

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21 January 2018

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

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Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA.

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21 January 2018

Multidrug resistance of DNA-mediated transformants is linked to transfer of the human mdr1 gene

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21 January 2018

Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors

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21 January 2018

Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction

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21 January 2018

Optimization of the single-strand conformation polymorphism (SSCP) technique for detection of point mutations.

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21 January 2018

Pharmacokinetics of Leucovorin Metabolites in Human Plasma as a Function of Dose Administrated Orally and Intravenously

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21 January 2018

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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21 January 2018

Growth-inhibitory effects of 5,10-dideazatetrahydrofolic acid on variant murine L1210 and human CCRF-CEM leukemia cells with different membrane-transport characteristics for (anti)folate compounds

1 reference

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21 January 2018

Determinants of the disparate antitumor activities of (6R)-5,10-dideaza-5,6,7,8-tetrahydrofolate and methotrexate toward human lymphoblastic leukemia cells, characterized by severely impaired antifolate membrane transport.

1 reference

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21 January 2018

pH dependence of methotrexate transport by the reduced folate carrier and the folate receptor in L1210 leukemia cells. Further evidence for a third route mediated at low pH.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.46.30189

21 January 2018

A mutated murine reduced folate carrier (RFC1) with increased affinity for folic acid, decreased affinity for methotrexate, and an obligatory anion requirement for transport function.

1 reference

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21 January 2018

Concentrating capacity of the human reduced folate carrier (hRFC1) in human ZR-75 breast cancer cell lines.

1 reference

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21 January 2018

Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines

1 reference

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21 January 2018

Loss of folic acid exporter function with markedly augmented folate accumulation in lipophilic antifolate-resistant mammalian cells

1 reference

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21 January 2018

Human K562 transfectants expressing high levels of reduced folate carrier but exhibiting low transport activity

1 reference

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21 January 2018

Leucovorin rescue of human cancer and bone marrow cells following edatrexate or methotrexate

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Importance of pharmacodynamics in the in vitro antiproliferative activity of the antifolates methotrexate and 10-ethyl-10-deazaaminopterin against human head and neck squamous cell carcinoma

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Functional aspects of membrane folate receptors in human breast cancer cells with transport-related resistance to methotrexate

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Alteration of mitochondrial gene expression and disruption of respiratory function by the lipophilic antifolate pyrimethamine in mammalian cells

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Disposition of leucovorin and its metabolites in the plasma, intestinal epithelium, and intraperitoneal L1210 cells of methotrexate-pretreated mice

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21 January 2018

Altered transport of folic acid and antifolates through the carrier mediated reduced folate transport system in a human leukemia cell line resistant to (6R) 5,10-dideazatetrahydrofolic acid (DDATHF).

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21 January 2018

Impact of overexpression of the reduced folate carrier (RFC1), an anion exchanger, on concentrative transport in murine L1210 leukemia cells

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21 January 2018

The role of impaired transport in (pre)clinical resistance to methotrexate: insights on new antifolates

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Identifiers

10.1074/JBC.273.46.30189

1 reference

Europe PubMed Central

25 May 2018

http://europepmc.org/abstract/MED/9804775

1 reference

Europe PubMed Central

25 May 2018

http://europepmc.org/abstract/MED/9804775

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