(Q34543848)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14668798%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

title

Stability of the Peutz-Jeghers syndrome kinase LKB1 requires its binding to the molecular chaperones Hsp90/Cdc37 (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14668798%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

main subject

molecular chaperones

0 references

Peutz-Jeghers syndrome

1 reference

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14668798%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

author name string

Pascale Nony

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14668798%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

Hélène Gaude

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14668798%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

Laurence Fournier

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14668798%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

Jean-Pierre Rouault

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14668798%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

Marc Billaud

6

1 reference

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21 December 2019

language of work or name

English

0 references

publication date

1 December 2003

1 reference

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21 December 2019

1 reference

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21 December 2019

volume

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14668798%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

issue

57

1 reference

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21 December 2019

page(s)

9165-9175

1 reference

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1207179

21 December 2019

exact match

0 references

cites work

LKB1 somatic mutations in sporadic tumors

1 reference

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7 January 2021

Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD

1 reference

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7 January 2021

Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation

1 reference

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7 January 2021

Interaction of activator of G-protein signaling 3 (AGS3) with LKB1, a serine/threonine kinase involved in cell polarity and cell cycle progression: phosphorylation of the G-protein regulatory (GPR) motif as a regulatory mechanism for the interaction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

The ubiquitin-proteasome pathway: the complexity and myriad functions of proteins death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

Increased risk of cancer in the Peutz-Jeghers syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

1 reference

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7 January 2021

Cdc37: a protein kinase chaperone?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

Generalized Intestinal Polyposis and Melanin Spots of the Oral Mucosa, Lips and Digits

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

LKB1 associates with Brg1 and is necessary for Brg1-induced growth arrest

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

Specific association of a set of molecular chaperones including HSP90 and Cdc37 with MOK, a member of the mitogen-activated protein kinase superfamily

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

Hsp90 inhibitors as novel cancer chemotherapeutic agents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

Peutz-Jeghers families unlinked to STK11/LKB1 gene mutations are highly predisposed to primitive biliary adenocarcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

Structure and in vivo function of Hsp90.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

A 50 kilodalton protein associated with raf and pp60(v-src) protein kinases is a mammalian homolog of the cell cycle control protein cdc37.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

Disruption of the Raf-1-Hsp90 molecular complex results in destabilization of Raf-1 and loss of Raf-1-Ras association

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

Cancer and the Peutz-Jeghers syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

The hsp90-binding antibiotic geldanamycin decreases Raf levels and epidermal growth factor signaling without disrupting formation of signaling complexes or reducing the specific enzymatic activity of Raf kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

Cloning and characterization of a novel serine/threonine protein kinase expressed in early Xenopus embryos

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

Growth arrest by the LKB1 tumor suppressor: induction of p21(WAF1/CIP1).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

Hsp90: a specialized but essential protein-folding tool

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207179

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207179

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14668798%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

21 December 2019

0 references

1 reference