(Q34553141)

23 June 2018

title

Genetics of coronary artery disease: discovery, biology and clinical translation (English)

1 reference

23 June 2018

main subject

coronary artery disease

1 reference

Amit V Khera

1

1 reference

23 June 2018

Sekar Kathiresan

series ordinal

2

1 reference

23 June 2018

publication date

13 March 2017

1 reference

23 June 2018

published in

Nature Reviews Genetics

1 reference

23 June 2018

volume

18

1 reference

23 June 2018

issue

6

1 reference

23 June 2018

page(s)

331-344

1 reference

23 June 2018

Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease

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7 July 2018

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Risk prediction by genetic risk scores for coronary heart disease is independent of self-reported family history

7 July 2018

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A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease

7 July 2018

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7 July 2018

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7 July 2018

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Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes

7 July 2018

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Efficacy and safety of evolocumab in reducing lipids and cardiovascular events.

7 July 2018

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Efficacy and safety of alirocumab in reducing lipids and cardiovascular events

7 July 2018

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Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials

7 July 2018

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ADAMTS-7 inhibits re-endothelialization of injured arteries and promotes vascular remodeling through cleavage of thrombospondin-1.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5935119

Knockout of Adamts7, a novel coronary artery disease locus in humans, reduces atherosclerosis in mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5935119

New loci and coding variants confer risk for age-related macular degeneration in East Asians

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5935119

Coronary heart disease and genetic variants with low phospholipase A2 activity

7 July 2018

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Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction

7 July 2018

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Inactivating mutations in NPC1L1 and protection from coronary heart disease

7 July 2018

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HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials

7 July 2018

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Effect of darapladib on major coronary events after an acute coronary syndrome: the SOLID-TIMI 52 randomized clinical trial

7 July 2018

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7 July 2018

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Rare-variant association analysis: study designs and statistical tests

7 July 2018

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Loss-of-function mutations in APOC3 and risk of ischemic vascular disease

7 July 2018

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Loss-of-function mutations in APOC3, triglycerides, and coronary disease

7 July 2018

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Permanent alteration of PCSK9 with in vivo CRISPR-Cas9 genome editing

7 July 2018

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A form of the metabolic syndrome associated with mutations in DYRK1B

7 July 2018

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Guidelines for investigating causality of sequence variants in human disease

7 July 2018

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Searching for missing heritability: designing rare variant association studies

7 July 2018

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Discovery and refinement of loci associated with lipid levels

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5935119

Common variants associated with plasma triglycerides and risk for coronary artery disease

7 July 2018

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Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society

7 July 2018

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Validating therapeutic targets through human genetics

7 July 2018

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7 July 2018

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ADAMTS7 cleavage and vascular smooth muscle cell migration is affected by a coronary-artery-disease-associated variant

7 July 2018

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RNA-guided human genome engineering via Cas9

7 July 2018

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7 July 2018

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7 July 2018

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Large-scale association analysis identifies new risk loci for coronary artery disease

7 July 2018

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Bayesian refinement of association signals for 14 loci in 3 common diseases

7 July 2018

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Systematic localization of common disease-associated variation in regulatory DNA

7 July 2018

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Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism

7 July 2018

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Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

7 July 2018

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The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials

7 July 2018

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Low lipoprotein(a) concentration is associated with cancer and all-cause deaths: a population-based cohort study (the JMS cohort study).

7 July 2018

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Genetic basis of atherosclerosis: insights from mice and humans

7 July 2018

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Rare and common variants: twenty arguments

7 July 2018

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Large-scale gene-centric analysis identifies novel variants for coronary artery disease

7 July 2018

1 reference

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A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease

7 July 2018

1 reference

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9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response

7 July 2018

1 reference

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Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5935119

Angptl4 protects against severe proinflammatory effects of saturated fat by inhibiting fatty acid uptake into mesenteric lymph node macrophages

7 July 2018

1 reference

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A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5935119

From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5935119

Biological, clinical and population relevance of 95 loci for blood lipids

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5935119

Lipoprotein(a) and risk of type 2 diabetes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5935119

PLA2G7 genotype, lipoprotein-associated phospholipase A2 activity, and coronary heart disease risk in 10 494 cases and 15 624 controls of European Ancestry

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5935119

Lipoprotein-associated phospholipase A(2) and risk of coronary disease, stroke, and mortality: collaborative analysis of 32 prospective studies

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5935119

Genetic heterogeneity in human disease

7 July 2018

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Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5935119

Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration

7 July 2018

1 reference

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How to improve R&D productivity: the pharmaceutical industry's grand challenge

7 July 2018

1 reference

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Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials

7 July 2018

1 reference

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Genetic variants associated with Lp(a) lipoprotein level and coronary disease.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5935119

Functional analysis of the chromosome 9p21.3 coronary artery disease risk locus.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5935119

New susceptibility locus for coronary artery disease on chromosome 3q22.3.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5935119

Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5935119

Genetic mapping in human disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5935119

Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5935119

Association of genetic variation on chromosome 9p21 with susceptibility and progression of atherosclerosis: a population-based, prospective study

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5935119

Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5935119

Newly identified loci that influence lipid concentrations and risk of coronary artery disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5935119

Genomewide association analysis of coronary artery disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5935119

Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5935119

A common allele on chromosome 9 associated with coronary heart disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5935119

A common variant on chromosome 9p21 affects the risk of myocardial infarction

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5935119

LRP6 mutation in a family with early coronary disease and metabolic risk factors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5935119

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5935119

Genetic susceptibility to coronary artery disease: from promise to progress.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5935119

Sibling cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5935119

Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5935119

The ENCODE (ENCyclopedia Of DNA Elements) Project

7 July 2018

1 reference

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Parental cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults: a prospective study of parents and offspring

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5935119

Mutation of MEF2A in an inherited disorder with features of coronary artery disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5935119

Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5935119

Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5935119

Review of first 5 years of screening for familial hypercholesterolaemia in the Netherlands

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5935119

Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5935119

Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5935119

Mutation in LDL receptor: Alu-Alu recombination deletes exons encoding transmembrane and cytoplasmic domains

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5935119

Association between a specific apolipoprotein B mutation and familial defective apolipoprotein B-100

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5935119

Lack of Association Between the MEF2A Gene and Myocardial Infarction

7 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.160

The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.160

ANRIL expression is associated with atherosclerosis risk at chromosome 9p21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.160

Evaluating the heritability explained by known susceptibility variants: a survey of ten complex diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.160

Dysfunctional nitric oxide signalling increases risk of myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.160

Darapladib for Preventing Ischemic Events in Stable Coronary Heart Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.160

Antisense Inhibition of Apolipoprotein C-III in Patients with Hypertriglyceridemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.160

Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.160

Computational neuroanatomy of speech production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.160

Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: a case-control study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.160

Polymorphisms associated with cholesterol and risk of cardiovascular events

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.160

Genomic prediction of coronary heart disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.160

Full Coverage for Preventive Medications after Myocardial Infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.160

The Public and the Gene-Editing Revolution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.160

Explaining the Decrease in U.S. Deaths from Coronary Disease, 1980–2000

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.160

Young candidates for coronary heart disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.160

Genetic susceptibility to death from coronary heart disease in a study of twins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.160

Heritability of death from coronary heart disease: a 36-year follow-up of 20 966 Swedish twins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.160

Common genetic variants on chromosome 9p21 confers risk of ischemic stroke: a large-scale genetic association study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.160

Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.160

Human knockouts in a cohort with a high rate of consanguinity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.160

31 March 2020

Identifiers

DOI

10.1038/NRG.2016.160

1 reference

23 June 2018

Dimensions Publication ID

0 references

1 reference

23 June 2018

PubMed publication ID

28286336

1 reference

23 June 2018