(Q34554631)

3 August 2017

title

SHP2 is a target of the immunosuppressant tautomycetin (English)

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3 August 2017

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4

Sheng-Xiong Huang

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3 August 2017

Sijiu Liu

1

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3 August 2017

Zhihong Yu

2

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3 August 2017

Xiao Yu

3

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3 August 2017

Yinggang Luo

5

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3 August 2017

Li Wu

6

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3 August 2017

Weihua Shen

7

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3 August 2017

Zhenyun Yang

8

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3 August 2017

Lina Wang

9

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3 August 2017

Andrea M Gunawan

10

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3 August 2017

Rebecca J Chan

11

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3 August 2017

Ben Shen

12

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3 August 2017

Zhong-Yin Zhang

13

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3 August 2017

publication date

1 January 2011

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3 August 2017

published in

Chemistry and Biology

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3 August 2017

volume

18

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3 August 2017

issue

1

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3 August 2017

page(s)

101-110

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Functional characterization of TtnD and TtnF, unveiling new insights into tautomycetin biosynthesis.

3 August 2017

cites work

1 reference

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Salicylic Acid Based Small Molecule Inhibitor for the Oncogenic Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2)

7 July 2018

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Increased c-Jun expression and reduced GATA2 expression promote aberrant monocytic differentiation induced by activating PTPN11 mutants

7 July 2018

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Functional characterization of ttmM unveils new tautomycin analogs and insight into tautomycin biosynthesis and activity.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034256

Characterization of the tautomycetin biosynthetic gene cluster from Streptomyces griseochromogenes provides new insight into dialkylmaleic anhydride biosynthesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034256

Large-scale structural analysis of the classical human protein tyrosine phosphatome

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034256

Characterization of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus unveiling new insights into dialkylmaleic anhydride and polyketide biosynthesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034256

Activating PTPN11 mutants promote hematopoietic progenitor cell-cycle progression and survival

7 July 2018

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Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

7 July 2018

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The tyrosine phosphatase Shp2 (PTPN11) in cancer.

7 July 2018

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Genetic and pharmacologic evidence implicating the p85 alpha, but not p85 beta, regulatory subunit of PI3K and Rac2 GTPase in regulating oncogenic KIT-induced transformation in acute myeloid leukemia and systemic mastocytosis

7 July 2018

1 reference

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PTP1B as a drug target: recent developments in PTP1B inhibitor discovery

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034256

Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034256

Protein tyrosine phosphatase function: the substrate perspective

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034256

Tautomycetin inhibits growth of colorectal cancer cells through p21cip/WAF1 induction via the extracellular signal-regulated kinase pathway

7 July 2018

1 reference

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Protein tyrosine phosphatases: from genes, to function, to disease

7 July 2018

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Noonan syndrome and related disorders: genetics and pathogenesis

7 July 2018

1 reference

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Intramolecular regulatory switch in ZAP-70: analogy with receptor tyrosine kinases.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034256

Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034256

Shp2, an SH2-containing protein-tyrosine phosphatase, positively regulates receptor tyrosine kinase signaling by dephosphorylating and inactivating the inhibitor Sprouty

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034256

Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034256

Molecular Mechanism for a Role of SHP2 in Epidermal Growth Factor Receptor Signaling

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034256

Mechanistic studies on protein tyrosine phosphatases

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034256

The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034256

Usage of tautomycetin, a novel inhibitor of protein phosphatase 1 (PP1), reveals that PP1 is a positive regulator of Raf-1 in vivo.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034256

Immunosuppressive effects of tautomycetin in vivo and in vitro via T cell-specific apoptosis induction

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034256

Protein tyrosine phosphatases: prospects for therapeutics

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034256

Structural basis for substrate specificity of protein-tyrosine phosphatase SHP-1

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034256

Signaling--2000 and beyond

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034256

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034256

Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034256

Improved methods for building protein models in electron density maps and the location of errors in these models

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034256

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034256

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034256

Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034256

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034256

Tautomycetin suppresses the TNFalpha/NF-kappaB pathway via inhibition of IKK activation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034256

Conditional deletion of Shp2 tyrosine phosphatase in thymocytes suppresses both pre-TCR and TCR signals.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034256

Tautomycetin as a novel immunosuppressant in transplantation

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034256

Tautomycetin is a novel and specific inhibitor of serine/threonine protein phosphatase type 1, PP1.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034256

Selective hypersensitivity to granulocyte-macrophage colony-stimulating factor by juvenile chronic myeloid leukemia hematopoietic progenitors

27 October 2018

1 reference

12 December 2020

Tautomycin from the bacterium Streptomyces verticillatus

1 reference

12 December 2020

The structure of tautomycin, a dialkylmaleic anhydride antibiotic

1 reference

12 December 2020

The structure of tautomycetin, a dialkylmaleic anhydride antibiotic

1 reference

12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

1 reference

12 December 2020

A new antibiotic, tautomycetin

1 reference

12 December 2020

A new antibiotic, tautomycin

1 reference

12 December 2020

Immunosuppressive agents: recent developments in molecular action and clinical application

1 reference

12 December 2020

10.1016/J.CHEMBIOL.2010.10.015

Identifiers

DOI

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3 August 2017

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3 August 2017

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