(Q34557003)

3 August 2017

1 reference

title

Class III receptor tyrosine kinases: role in leukaemogenesis (English)

1 reference

3 August 2017

John T Reilly

1

1 reference

PubMed ID

11886377

3 August 2017

language of work or name

English

0 references

publication date

1 March 2002

1 reference

British Journal of Haematology

3 August 2017

1 reference

3 August 2017

116

1 reference

3 August 2017

4

1 reference

3 August 2017

744-757

1 reference

Identification of novel FLT-3 Asp835 mutations in adult acute myeloid leukaemia

3 August 2017

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Translocation t(5;12)(q31-q33;p12-p13): a non-random translocation associated with a myeloid disorder with eosinophilia

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Identification of activating c-kit mutations in adult-, but not in childhood-onset indolent mastocytosis: a possible explanation for divergent clinical behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

The TEL/platelet-derived growth factor beta receptor (PDGF beta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta R kinase-dependent signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Signal transduction by the PDGF receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Constitutive activation of FLT3 in acute myeloid leukaemia and its consequences for growth of 32D cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Mutation analysis of C-KIT in patients with myelodysplastic syndromes without mastocytosis and cases of systemic mastocytosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Inhibition of human natural killer cell activity by platelet-derived growth factor (PDGF). III. Membrane binding studies and differential biological effect of recombinant PDGF isoforms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Frequent c-fms activation by proviral insertion in mouse myeloblastic leukaemias.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Point mutations in the FLT3 gene in AML.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Chromosomal localization of the human c-fms oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

The human PDGF receptor ?-subunit gene maps to chromosome 4 in close proximity to c-kit

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

A single amino acid substitution in a WW-like domain of diverse members of the PDGF receptor subfamily of tyrosine kinases causes constitutive receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Active and inactive protein kinases: structural basis for regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Basis of hematopoietic defects in platelet-derived growth factor (PDGF)-B and PDGF beta-receptor null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Expression, function and activation of the proto-oncogene c-kit product in human leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Structure, organization, and transcription units of the human alpha-platelet-derived growth factor receptor gene, PDGFRA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Abnormalities of chromosome 12p13 and malignant proliferation of eosinophils: a nonrandom association.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

c-kit Point mutation in patients with myeloproliferative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Activating and dominant inactivating c-KIT catalytic domain mutations in distinct clinical forms of human mastocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Classes of c-KIT activating mutations: proposed mechanisms of action and implications for disease classification and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Inhibition of spontaneous receptor phosphorylation by residues in a putative alpha-helix in the KIT intracellular juxtamembrane region.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Independent expression of human alpha or beta platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Prevalence and prognostic significance of Flt3 internal tandem duplication in pediatric acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Cell specific transformation by c-fms activating loop mutations is attributable to constitutive receptor degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Tyrosine phosphorylations in vivo associated with v-fms transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Molecular evolution of acute myeloid leukaemia in relapse: unstable N-ras and FLT3 genes compared with p53 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Signal transducer and activator of transcription 3 activation is required for Asp(816) mutant c-Kit-mediated cytokine-independent survival and proliferation in human leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Myelodysplastic syndrome with t(5;12)(q31;p12-p13) and eosinophilia: a pediatric case with review of literature.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Tyrosine kinase receptor-activated signal transduction pathways which lead to oncogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Cellular signalling pathways: new targets in leukaemia therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Synergistic up-regulation of the myeloid-specific promoter for the macrophage colony-stimulating factor receptor by AML1 and the t(8;21) fusion protein may contribute to leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

FMS mutations in myelodysplastic, leukemic, and normal subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Tandem linkage of human CSF-1 receptor (c-fms) and PDGF receptor genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

The protein tyrosine kinase family of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Transforming potential of the c-fms proto-oncogene (CSF-1 receptor).

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

A point mutation in the extracellular domain of the human CSF-1 receptor (c-fms proto-oncogene product) activates its transforming potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Specific binding of the mononuclear phagocyte colony-stimulating factor CSF-1 to the product of the v-fms oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

H4(D10S170), a gene frequently rearranged in papillary thyroid carcinoma, is fused to the platelet-derived growth factor receptor beta gene in atypical chronic myeloid leukemia with t(5;10)(q33;q22).

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor (c-kit) in a human myeloid leukemia cell line and in acute myeloid leukemia blasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Detection of c-kit mutation Asp 816 to Val in microdissected bone marrow infiltrates in a case of systemic mastocytosis associated with chronic myelomonocytic leukaemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Activating c-kit gene mutations in human germ cell tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Fatal myeloproliferation, induced in mice by TEL/PDGFbetaR expression, depends on PDGFbetaR tyrosines 579/581

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Functional receptor for GDNF encoded by the c-ret proto-oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Induction of mast cell proliferation, maturation, and heparin synthesis by the rat c-kit ligand, stem cell factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Constitutive activation of FLT3 stimulates multiple intracellular signal transducers and results in transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Substitution of an aspartic acid results in constitutive activation of c-kit receptor tyrosine kinase in a rat tumor mast cell line RBL-2H3

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Signal transduction by receptors with tyrosine kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Oncogenic activation of the alphaPDGFR defines a domain that negatively regulates receptor dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Switching signals on or off by receptor dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

t(5;12)(q31;p12). A clinical entity with features of both myeloid leukemia and chronic myelomonocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Activation of the feline c-fms proto-oncogene: multiple alterations are required to generate a fully transformed phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Tandem duplication of the FLT3 gene is found in acute lymphoblastic leukaemia as well as acute myeloid leukaemia but not in myelodysplastic syndrome or juvenile chronic myelogenous leukaemia in children

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

In vivo treatment of mutant FLT3-transformed murine leukemia with a tyrosine kinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Expression and Signal Transduction of the FLT3 Tyrosine Kinase Receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

Systemic mastocytosis associated with acute myeloid leukaemia: report of two cases and detection of the c-kit mutation Asp-816 to Val

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03294.X

10.1046/J.0007-1048.2001.03294.X

21 January 2018

Identifiers

DOI

1 reference

3 August 2017

1 reference

PubMed ID

11886377