(Q34559582)

3 August 2017

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title

The effect of HMG-CoA reductase inhibitors on coenzyme Q10: possible biochemical/clinical implications (English)

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3 August 2017

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Iain P Hargreaves

1

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3 August 2017

Andrew J Duncan

series ordinal

2

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3 August 2017

Simon J R Heales

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3

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3 August 2017

John M Land

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4

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3 August 2017

language of work or name

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1 January 2005

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3 August 2017

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3 August 2017

28

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3 August 2017

659-676

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3 August 2017

8

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https://scigraph.springernature.com/pub.10.2165/00002018-200528080-00002

3 August 2017

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cites work

Comparative pharmacokinetics of lovastatin, simvastatin and pravastatin in humans

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12 December 2020

Measurement of the ratio between the reduced and oxidized forms of coenzyme Q10 in human plasma as a possible marker of oxidative stress

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12 December 2020

Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group

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12 December 2020

Serum ubiquinone concentrations after short- and long-term treatment with HMG-CoA reductase inhibitors

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12 December 2020

Interactions between ascorbyl free radical and coenzyme Q at the plasma membrane

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12 December 2020

Interactions with hydroxymethylglutaryl-coenzyme A reductase inhibitors.

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12 December 2020

Simvastatin-induced lactic acidosis: a rare adverse reaction?

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12 December 2020

Effects of regular consumption of grapefruit juice on the pharmacokinetics of simvastatin

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12 December 2020

Coenzyme Q10 and coronary artery disease

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12 December 2020

Strategies for the prevention and treatment of statin-induced myopathy: is there a role for ubiquinone supplementation?

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12 December 2020

Oxidation of LDL and their subfractions: kinetic aspects and CoQ10 content

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12 December 2020

Plasma coenzyme Q (ubiquinone) concentrations in patients treated with simvastatin.

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12 December 2020

The interaction of diltiazem with simvastatin

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12 December 2020

Learning from the cerivastatin experience

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12 December 2020

Relevance of the biosynthesis of coenzyme Q10 and of the four bases of DNA as a rationale for the molecular causes of cancer and a therapy

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12 December 2020

Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study

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12 December 2020

Nonalcoholic fatty liver (NASH syndrome).

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12 December 2020

Regulatory aspects of coenzyme Q metabolism

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12 December 2020

Serum and muscle tissue ubiquinone levels in healthy subjects

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12 December 2020

Increased oxidative stress in patients with congestive heart failure

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12 December 2020

Drug treatment of lipid disorders

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12 December 2020

Coenzyme Q deficiency in mitochondria: kinetic saturation versus physical saturation

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12 December 2020

The effect of Simvastatin on the plasma antioxidant concentrations in patients with hypercholesterolaemia

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12 December 2020

An overview of the clinical safety profile of atorvastatin (lipitor), a new HMG-CoA reductase inhibitor

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12 December 2020

New advances in lipid-modifying therapies for reducing cardiovascular risk

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12 December 2020

Role of plasma membrane coenzyme Q on the regulation of apoptosis

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12 December 2020

[Mitochondrial enzymes in circulating lymphocytes during hemosorption for experimental hypercholesterolemia]

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12 December 2020

Coenzyme Q10 and differences in coronary heart disease risk in Asian Indians and Chinese

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12 December 2020

Pravastatin. A review of its pharmacological properties and therapeutic potential in hypercholesterolaemia

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12 December 2020

Lovastatin decreases coenzyme Q levels in humans

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12 December 2020

Discovery, biochemistry and biology of lovastatin

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12 December 2020

Effects of HMG-CoA reductase inhibitors on skeletal muscle: are all statins the same?

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12 December 2020

Coenzyme Q10 reverses pathological phenotype and reduces apoptosis in familial CoQ10 deficiency

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12 December 2020

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12 December 2020

The effect of simvastatin treatment on natural antioxidants in low-density lipoproteins and high-energy phosphates and ubiquinone in skeletal muscle

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12 December 2020

The protonmotive Q cycle: A general formulation

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12 December 2020

The protonmotive Q cycle. Energy transduction by coupling of proton translocation to electron transfer by the cytochrome bc1 complex

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12 December 2020

The myotoxicity of statins

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12 December 2020

Metabolism and function of coenzyme Q.

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12 December 2020

Role of coenzyme Q10 in chronic heart failure, angina, and hypertension

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12 December 2020

Mitochondrial cardiomyopathy: molecular and biochemical analysis

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12 December 2020

Metabolic cardiomyopathies

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12 December 2020

Isolation of a quinone from beef heart mitochondria

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12 December 2020

Lipoprotein oxidation in dyslipidemia: insights into general mechanisms affecting lipoprotein oxidative behavior.

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12 December 2020

Plasma ubiquinol/cholesterol ratios in patients with hyperlipidaemia, those with diabetes mellitus and in patients requiring dialysis

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12 December 2020

Muscle coenzyme Q deficiency in familial mitochondrial encephalomyopathy

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12 December 2020

Expanded Clinical Evaluation of Lovastatin (EXCEL) study results: two-year efficacy and safety follow-up

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12 December 2020

A role for reduced coenzyme Q in atherosclerosis?

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12 December 2020

Lovastatin decreases coenzyme Q levels in rats

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12 December 2020

Physiological disposition of HMG-CoA-reductase inhibitors

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12 December 2020

HMG-CoA reductase inhibitors (statins) characterized as direct inhibitors of P-glycoprotein

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12 December 2020

Hepatotoxicity of commonly used drugs: nonsteroidal anti-inflammatory drugs, antihypertensives, antidiabetic agents, anticonvulsants, lipid-lowering agents, psychotropic drugs.

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12 December 2020

Lipid-lowering drugs and mitochondrial function: effects of HMG-CoA reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio

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12 December 2020

Effects of HMG-CoA reductase inhibitors on skeletal muscles of rabbits

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12 December 2020

Myopathy induced by HMG-CoA reductase inhibitors in rabbits: a pathological, electrophysiological, and biochemical study.

1 reference

12 December 2020

Synthesis of delta 2-isopentenyl tRNA from mevalonate in cultured human fibroblasts

1 reference

12 December 2020

Effects of lipid-lowering drugs on left ventricular function and exercise tolerance in dyslipidemic coronary patients

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12 December 2020

HMG-CoA reductase inhibitors for treatment of hypercholesterolemia

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12 December 2020

Antioxidant and prooxidant properties of mitochondrial Coenzyme Q.

1 reference

12 December 2020

Lovastatin, isoprenes, and myopathy

1 reference

12 December 2020

Clinical pharmacokinetics of statins

1 reference

12 December 2020

Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels

1 reference

12 December 2020

Inhibition of human vascular smooth muscle cell proliferation by lovastatin: the role of isoprenoid intermediates of cholesterol synthesis

1 reference

12 December 2020

Lipid peroxidation and changes in the ubiquinone content and the respiratory chain enzymes of submitochondrial particles

1 reference

12 December 2020

Blood mononuclear cell coenzyme Q10 concentration and mitochondrial respiratory chain succinate cytochrome‐c reductase activity in phenylketonuric patients

1 reference

12 December 2020

High-performance liquid chromatography of coenzyme Q-related compounds and its application to biological materials

1 reference

12 December 2020

Atorvastatin. A review of its pharmacology and therapeutic potential in the management of hyperlipidaemias

1 reference

12 December 2020

Rhabdomyolysis, acute renal failure and hepatopathy induced by lovastatin monotherapy

1 reference

12 December 2020

Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke

1 reference

12 December 2020

Plasma ubiquinone, alpha-tocopherol and cholesterol in man

1 reference

12 December 2020

Statins unmasking a mitochondrial myopathy: a case report and proposed mechanism of disease

1 reference

12 December 2020

Influences of lovastatin administration on the respiratory burst of leukocytes and the phosphorylation potential of mitochondria in guinea pigs

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12 December 2020

1 reference

12 December 2020

Lovastatin increases exercise-induced skeletal muscle injury

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12 December 2020

Over-the-counter statins

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12 December 2020

Coenzyme Q10: clinical benefits with biochemical correlates suggesting a scientific breakthrough in the management of chronic heart failure.

1 reference

12 December 2020

Effect of simvastatin therapy on blood and tissue ATP levels and erythrocyte membrane lipid composition

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12 December 2020

Reduced ubiquinone plasma levels in patients with liver cirrhosis and in chronic alcoholics

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12 December 2020

Ubiquinone: cholesterol's reclusive cousin

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12 December 2020

Biosynthesis of Ubiquinone

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12 December 2020

Effect of treatment with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on serum coenzyme Q10 in diabetic patients

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12 December 2020

The role of oxidized lipoproteins in atherogenesis

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12 December 2020

HMG-CoA reductase inhibitors and myotoxicity

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12 December 2020

The effect of pravastatin and atorvastatin on coenzyme Q10.

1 reference

12 December 2020

A review of the pharmacologic and pharmacokinetic aspects of rosuvastatin

1 reference

12 December 2020

A phylogenetic study of ubiquinone Q-8 species of the genera Candida, Pichia, and Citeromyces based on 18S ribosomal DNA sequence divergence.

1 reference

12 December 2020

A review on the diagnosis, natural history, and treatment of familial hypercholesterolaemia

1 reference

12 December 2020

Biochemical rationale and myocardial tissue data on the effective therapy of cardiomyopathy with coenzyme Q10.

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12 December 2020

Statins--similarities and differences.

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12 December 2020

Ubiquinone supplementation during lovastatin treatment: effect on LDL oxidation ex vivo.

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12 December 2020

Biochemical, physiological and medical aspects of ubiquinone function

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12 December 2020

Dietary supplementation with coenzyme Q10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low-density lipoprotein to the initiation of lipid peroxidation.

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12 December 2020

MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial

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12 December 2020

Enhanced oxidizability of ubiquinol and alpha-tocopherol during lovastatin treatment.

1 reference

12 December 2020

Clinically relevant differences between the statins: implications for therapeutic selection

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12 December 2020

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12 December 2020

Distribution and redox state of ubiquinones in rat and human tissues

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12 December 2020

Pharmacologic characteristics of statins

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12 December 2020

Choice of lipid-regulating drugs

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12 December 2020

Clinical pharmacokinetics of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors

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12 December 2020

Safety and tolerability of cholesterol lowering with simvastatin during 5 years in the Scandinavian Simvastatin Survival Study

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12 December 2020

Preclinical pharmacokinetics of statins.

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12 December 2020

Biochemical functions of coenzyme Q10

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12 December 2020

Interactions between ubiquinones and vitamins in membranes and cells

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12 December 2020

Distribution of antioxidants among blood components and lipoproteins: significance of lipids/CoQ10 ratio as a possible marker of increased risk for atherosclerosis

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12 December 2020

Statins: effective antiatherosclerotic therapy

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12 December 2020

The coenzyme Q10 content of the average Danish diet.

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12 December 2020

Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression

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12 December 2020

Neonatal presentation of coenzyme Q10 deficiency

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12 December 2020

Treating dyslipidemia with statins: the risk-benefit profile

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12 December 2020

Determinants of plasma coenzyme Q10 in humans

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12 December 2020

Simvastatin-induced rhabdomyolysis followed by a MELAS syndrome

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12 December 2020

Exogenous CoQ10 supplementation prevents plasma ubiquinone reduction induced by HMG-CoA reductase inhibitors

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12 December 2020

HMG-CoA reductase inhibitors: assessing differences in drug interactions and safety profiles

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12 December 2020

Decreases in serum ubiquinone concentrations do not result in reduced levels in muscle tissue during short-term simvastatin treatment in humans

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12 December 2020

Statin precipitated lactic acidosis?

1 reference

12 December 2020

Comparison of one-year efficacy and safety of atorvastatin versus lovastatin in primary hypercholesterolemia. Atorvastatin Study Group I.

1 reference

12 December 2020

Ubiquinone biosynthesis by the microsomal fraction from rat liver

1 reference

12 December 2020

Statins and coenzyme Q10.

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12 December 2020

Clinical implications of the correlation between coenzyme Q10 and vitamin B6 status.

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12 December 2020

Risk for myopathy with statin therapy in high-risk patients.

1 reference

12 December 2020

Acute cholestatic hepatitis associated with pravastatin

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12 December 2020

Screening for statin-related toxicity: the yield of transaminase and creatine kinase measurements in a primary care setting

1 reference

12 December 2020

Cholestatic jaundice associated with lovastatin (Mevacor) therapy

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12 December 2020

Statin-associated myopathy

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12 December 2020

Long-term safety of hepatic hydroxymethyl glutaryl coenzyme A reductase inhibitors: the role of metabolism-monograph for physicians

1 reference

12 December 2020

Lack of effect of lovastatin on restenosis after coronary angioplasty. Lovastatin Restenosis Trial Study Group

1 reference

12 December 2020

Comparative tolerability of the HMG-CoA reductase inhibitors

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12 December 2020

Regulation of ubiquinone metabolism

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12 December 2020

Saturation kinetics of coenzyme Q in NADH and succinate oxidation in beef heart mitochondria

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12 December 2020

Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: a double-blind, placebo-controlled study

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12 December 2020

Statin-associated myopathy with normal creatine kinase levels

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12 December 2020

Localization and mobility of coenzyme Q in lipid bilayers and membranes

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12 December 2020

Intensification of free radical oxidation of low-density lipoproteins in the plasma of patients with ischemic heart disease receiving beta-hydroxy-beta-methylglutaryl-coenzyme A reductase inhibitor cerivastatin and inhibition of low-density lipoprot

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12 December 2020

Coenzyme Q10 in neurodegenerative diseases

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12 December 2020

Coenzyme Q10 concentrations in coronary artery disease

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12 December 2020

Extracellular reduction of ubiquinone-1 and -10 by human Hep G2 and blood cells

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12 December 2020

Inhibitor of beta-hydroxy-beta-methylglutaryl coenzyme A reductase decreases energy supply to the myocardium in rats

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12 December 2020

Treatment of patients with lipid disorders in the primary care setting: new treatment guidelines and their implications

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12 December 2020

Coenzyme Q is an obligatory cofactor for uncoupling protein function

1 reference

12 December 2020

No difference in ubiquinone concentration of muscles and blood in fibromyalgia patients and healthy controls

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12 December 2020

Defining patient risks from expanded preventive therapies

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12 December 2020

10.2165/00002018-200528080-00002

Identifiers

DOI

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Dimensions Publication ID

3 August 2017

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