(Q34559688)

3 August 2017

title

Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independent of obesity (English)

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48

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49

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Françoise Clavel-Chapelon

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Françoise Clavel-Chapelon

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Inês Barroso

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Inês Barroso

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Claudia Langenberg

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Claudia Langenberg

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Vilmantas Giedraitis

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Vilmantas Giedraitis

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Heiner Boeing

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Heiner Boeing

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3 August 2017

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Aurelio Barricarte

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Luca A Lotta

Luca A Lotta

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Nita G. Forouhi

Nita G Forouhi

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Sara Grioni

Sara Grioni

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Matthias B Schulze

Matthias B Schulze

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Paul W. Franks

Paul W Franks

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Carlotta Sacerdote

Carlotta Sacerdote

33

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Domenico Palli

Domenico Palli

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Anne Tjønneland

Anne Tjonneland

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Rudolf Kaaks

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Rudolf Kaaks

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3 August 2017

David B Savage

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Rosario Tumino

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Rosario Tumino

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27

Kim Overvad

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Afshan Siddiq

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Mark McCarthy

Mark I McCarthy

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Salvatore Panico

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Salvatore Panico

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Nicholas J Wareham

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Erik Ingelsson

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Guy Fagherazzi

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2

Tove Fall

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Hanieh Yaghootkar

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Jacqueline M Dekker

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Nadia Slimani

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Ele Ferrannini

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Tilman Kühn

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Stephen J Sharp

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Robert A Scott

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Leif C Groop

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Ivonne Sluijs

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Olov Rolandsson

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3 August 2017

Annemieke M W Spijkerman

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Annemieke Mw Spijkerman

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Francesca L Crowe

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Dorota Pasko

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Larraitz Arriola

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Beverley Balkau

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Nina Roswall

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Diana Gavrila

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3 August 2017

María José Sánchez Pérez

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María-José Sánchez

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3 August 2017

Adam Barker

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Timothy J Key

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Peter M Nilsson

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J Ramón Quirós

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Núria Sala

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Daphne L van der A

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3 August 2017

RISC study group

45

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3 August 2017

EPIC-InterAct consortium

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3 August 2017

Mark Walker

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Tim M Frayling

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3 August 2017

language of work or name

English

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publication date

19 June 2014

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3 August 2017

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3 August 2017

volume

63

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3 August 2017

issue

12

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3 August 2017

page(s)

4378-4387

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Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity

3 August 2017

cites work

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7 July 2018

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Type 2 diabetes with partial lipodystrophy of the limbs: a new lipodystrophy phenotype

7 July 2018

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Hyperinsulinemia drives diet-induced obesity independently of brain insulin production

7 July 2018

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An integrated map of genetic variation from 1,092 human genomes

7 July 2018

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Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

7 July 2018

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Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases

7 July 2018

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Long-term risk of incident type 2 diabetes and measures of overall and regional obesity: the EPIC-InterAct case-cohort study

7 July 2018

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A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

7 July 2018

1 reference

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Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes

7 July 2018

1 reference

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Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study

7 July 2018

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Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

7 July 2018

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Genetic Syndromes of Severe Insulin Resistance

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241116

Genetic predisposition to obesity leads to increased risk of type 2 diabetes

7 July 2018

1 reference

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Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

7 July 2018

1 reference

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Biological, clinical and population relevance of 95 loci for blood lipids

7 July 2018

1 reference

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Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

7 July 2018

1 reference

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Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241116

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241116

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241116

Gluteofemoral body fat as a determinant of metabolic health.

7 July 2018

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Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome--an allostatic perspective

7 July 2018

1 reference

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Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis

7 July 2018

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Identification and characterization of metabolically benign obesity in humans

7 July 2018

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Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241116

Why might South Asians be so susceptible to central obesity and its atherogenic consequences? The adipose tissue overflow hypothesis

7 July 2018

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Disordered lipid metabolism and the pathogenesis of insulin resistance

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241116

Incidence of Type 2 diabetes in England and its association with baseline impaired fasting glucose: the Ely study 1990-2000.

7 July 2018

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Mechanisms linking obesity to insulin resistance and type 2 diabetes

7 July 2018

1 reference

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The EGIR-RISC STUDY (The European group for the study of insulin resistance: relationship between insulin sensitivity and cardiovascular disease risk): I. Methodology and objectives

7 July 2018

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The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241116

Nonalcoholic fatty liver disease

7 July 2018

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Are there persons who are obese, but metabolically healthy?

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241116

Essential role of insulin receptor substrate 1 in differentiation of brown adipocytes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241116

Evaluation of abnormal liver-enzyme results in asymptomatic patients

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241116

Insulin Secretion in Response to Glycemic Stimulus: Relation of Delayed Initial Release to Carbohydrate intolerance in Mild Diabetes Mellitus*

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241116

Glucose clamp technique: a method for quantifying insulin secretion and resistance

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241116

Association between birth weight and visceral fat in adults

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241116

Proinsulin and acute insulin response independently predict Type 2 diabetes mellitus in men--report from 27 years of follow-up study

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241116

Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241116

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241116

27 October 2018

Identifiers

DOI

10.2337/DB14-0319

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3 August 2017

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3 August 2017

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