(Q34571029)

3 August 2017

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title

Discovery and development of clofarabine: a nucleoside analogue for treating cancer (English)

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3 August 2017

Peter L Bonate

1

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3 August 2017

Larry Arthaud

2

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3 August 2017

William R Cantrell

3

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3 August 2017

Katherine Stephenson

4

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3 August 2017

John A Secrist

5

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3 August 2017

Steve Weitman

6

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3 August 2017

publication date

1 October 2006

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Nature Reviews Drug Discovery

3 August 2017

published in

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3 August 2017

volume

5

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3 August 2017

issue

10

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3 August 2017

page(s)

855-863

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https://scigraph.springernature.com/pub.10.1038/nrd2055

3 August 2017

exact match

0 references

cites work

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Augmented Berlin-Frankfurt-Munster therapy abrogates the adverse prognostic significance of slow early response to induction chemotherapy for children and adolescents with acute lymphoblastic leukemia and unfavorable presenting features: a report fr

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Duration of first remission predicts remission rates and long-term survival in children with relapsed acute myelogenous leukemia

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Second allogeneic bone marrow transplantation in acute leukemia: a multicenter study from the Gruppo Italiano Trapianto Di Midollo Osseo (GITMO)

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Bone marrow transplants from HLA-identical siblings as compared with chemotherapy for children with acute lymphoblastic leukemia in a second remission.

31 March 2020

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Cytotoxicity and pharmacokinetics of cladribine metabolite, 2-chloroadenine in patients with leukemia

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2-fluoro-ATP: a toxic metabolite of 9-beta-D-arabinosyl-2-fluoroadenine

31 March 2020

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Synthesis and biological activity of 2'-fluoro-2-halo derivatives of 9-.beta.-D-arabinofuranosyladenine

31 March 2020

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A comparison of the transportability, and its role in cytotoxicity, of clofarabine, cladribine, and fludarabine by recombinant human nucleoside transporters produced in three model expression systems

31 March 2020

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Properties and levels of deoxynucleoside kinases in normal and tumor cells; implications for chemotherapy

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Mammalian deoxyribonucleoside kinases

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Activation of deoxycytidine kinase by various nucleoside analogues.

31 March 2020

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New targets for pyrimidine antimetabolites for the treatment of solid tumours. 2: Deoxycytidine kinase

31 March 2020

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Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine

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Preclinical antitumor activity of 2-chloro-9-(2-deoxy-2-fluoro-beta-D- arabinofuranosyl)adenine (Cl-F-ara-A).

31 March 2020

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Antitumor activity of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) adenine, a novel deoxyadenosine analog, against human colon tumor xenografts by oral administration

31 March 2020

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Pharmacokinetics of the anticancer agent 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine in rats

31 March 2020

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Treatment of normal and malignant cells with nucleoside analogues and etoposide enhances deoxycytidine kinase activity

31 March 2020

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Biochemical modulation of cytarabine triphosphate by clofarabine.

31 March 2020

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Clinical and pharmacokinetic study of clofarabine in chronic lymphocytic leukemia: strategy for treatment

31 March 2020

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Population pharmacokinetics of clofarabine, a second-generation nucleoside analog, in pediatric patients with acute leukemia

31 March 2020

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31 March 2020

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Phase 2 clinical and pharmacologic study of clofarabine in patients with refractory or relapsed acute leukemia

31 March 2020

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Clofarabine, a novel nucleoside analog, is active in pediatric patients with advanced leukemia

31 March 2020

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Phase II study of clofarabine in pediatric patients with refractory or relapsed acute lymphoblastic leukemia

31 March 2020

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Results of a phase 1-2 study of clofarabine in combination with cytarabine (ara-C) in relapsed and refractory acute leukemias

31 March 2020

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Nucleoside transporters: molecular biology and implications for therapeutic development

31 March 2020

1 reference

The distribution, metabolism, and elimination of clofarabine in rats

31 March 2020

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Distribution of 2-chloro-2'-deoxyadenosine, 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine, fludarabine and cytarabine in mice: a whole-body autoradiography study.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRD2055

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3 August 2017

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