(Q40643843)

22 September 2017

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title

New targets for pyrimidine antimetabolites for the treatment of solid tumours. 2: Deoxycytidine kinase (English)

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22 September 2017

V W Ruiz van Haperen

1

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22 September 2017

G J Peters

series ordinal

2

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22 September 2017

language of work or name

English

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publication date

1 April 1994

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International Journal of Clinical Pharmacy

22 September 2017

published in

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22 September 2017

volume

16

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22 September 2017

issue

2

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22 September 2017

page(s)

104-112

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Differences in deoxycytidine metabolism in mouse and rat.

22 September 2017

cites work

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FBF01880661

Comparison of the antileukaemic activity of 5 aza-2-deoxycytidine and arabinofuranosyl-cytosine in rats with myelocytic leukaemia

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FBF01880661

The influence of the schedule and the dose of gemcitabine on the anti-tumour efficacy in experimental human cancer

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FBF01880661

Resistance to 1-beta-D-arabinofuranosylcytosine in human T-lymphoblasts mediated by mutations within the deoxycytidine kinase gene

21 January 2018

1 reference

12 December 2020

Laboratory and clinical studies of biochemical modulation by hydroxyurea

1 reference

12 December 2020

Cellular elimination of 2',2'-difluorodeoxycytidine 5'-triphosphate: a mechanism of self-potentiation

1 reference

12 December 2020

Phase I and pharmacokinetic study of 5-aza-2'-deoxycytidine (NSC 127716) in cancer patients

1 reference

12 December 2020

Decreased DNA polymerase sensitivity to 1-beta-D-arabinofuranosylcytosine 5'-triphosphate in P388 murine leukemic cells resistant to vincristine

1 reference

12 December 2020

In vitro biological activity of 9-beta-D-arabinofuranosyl-2-fluoroadenine and the biochemical actions of its triphosphate on DNA polymerases and ribonucleotide reductase from HeLa cells

1 reference

12 December 2020

Biochemical modulation of cytosine arabinoside

1 reference

12 December 2020

High dose cytarabine: a review

1 reference

12 December 2020

Sequence-specific effects of ara-5-aza-CTP and ara-CTP on DNA synthesis by purified human DNA polymerases in vitro: visualization of chain elongation on a defined template

1 reference

12 December 2020

Metabolism and mechanism of antiretroviral action of purine and pyrimidine derivatives

1 reference

12 December 2020

Deoxycytidine kinase-mediated toxicity of deoxyadenosine analogs toward malignant human lymphoblasts in vitro and toward murine L1210 leukemia in vivo

1 reference

12 December 2020

Deoxycytidine kinase. II. Purification and general properties of the calf thymus enzyme.

1 reference

12 December 2020

Deoxycytidine kinase. I. Distribution in normal and neoplastic tissues and interrelationships of deoxycytidine and 1-beta-D-arabinofuranosylcytosine phosphorylation

1 reference

12 December 2020

Correlation between leukemic cell retention of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate and response to therapy

1 reference

12 December 2020

Cytidine deaminase and the development of resistance to arabinosyl cytosine.

1 reference

12 December 2020

2-Chlorodeoxyadenosine: an effective new agent for the treatment of chronic lymphocytic leukemia

1 reference

12 December 2020

Quantitation of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate in the leukemic cells from bone marrow and peripheral blood of patients receiving 1-beta-D-arabinofuranosylcytosine therapy

1 reference

12 December 2020

Preclinical in vivo activity of 2',2'-difluorodeoxycytidine (Gemcitabine) against human head and neck cancer

1 reference

12 December 2020

Induction of internucleosomal DNA fragmentation in human myeloid leukemia cells by 1-beta-D-arabinofuranosylcytosine.

1 reference

12 December 2020

Deoxycytidine kinase from human leukemic spleen: preparation and characteristics of homogeneous enzyme

1 reference

12 December 2020

Action of 2',2'-difluorodeoxycytidine on DNA synthesis

1 reference

12 December 2020

Genomic structure and chromosomal localization of the human deoxycytidine kinase gene

1 reference

12 December 2020

Human T-lymphoblast deoxycytidine kinase: purification and properties

1 reference

12 December 2020

Identification of the mechanism of activation of 9-beta-D-arabinofuranosyladenine in human lymphoid cells using mutants deficient in nucleoside kinases

1 reference

12 December 2020

A critical role for uridine nucleotides in the regulation of deoxycytidine kinase and the concentration dependence of 1-beta-D-arabinofuranosylcytosine phosphorylation in human leukemia cells.

1 reference

12 December 2020

Deoxycytidine kinase: properties of the enzyme from human leukemic granulocytes

1 reference

12 December 2020

Cytokinetic changes after cytosine arabinoside in acute non-lymphocytic leukemia

1 reference

12 December 2020

Studies on a new mechanism of resistance of L5178Y murine leukemia cells to cytosine arabinoside.

1 reference

12 December 2020

5-Aza-2'-deoxycytidine (Decitabine) and 5-azacytidine in the treatment of acute myeloid leukemias and myelodysplastic syndromes: past, present and future trends

1 reference

12 December 2020

Nucleotide specificity of human deoxycytidine kinase

1 reference

12 December 2020

Modulation of deoxycytidylate deaminase in intact human leukemia cells. Action of 2',2'-difluorodeoxycytidine

1 reference

12 December 2020

Inhibition of ribonucleotide reduction in CCRF-CEM cells by 2',2'-difluorodeoxycytidine

1 reference

12 December 2020

2',2'-Difluoro-deoxycytidine (gemcitabine) incorporation into RNA and DNA of tumour cell lines

1 reference

12 December 2020

Deoxycytidine kinase. 3. Kinetics and allosteric regulation of the calf thymus enzyme

1 reference

12 December 2020

1 reference

12 December 2020

5-Aza-2'-deoxycytidine: cell differentiation and DNA methylation.

1 reference

12 December 2020

Relationships among Ara-CTP pools, formation of (Ara-C)DNA, and cytotoxicity of human leukemic cells

1 reference

12 December 2020

Specific toxicity of 2-chlorodeoxyadenosine toward resting and proliferating human lymphocytes

1 reference

12 December 2020

Phenotypic analysis of 1-B-D-arabinofuranosylcytosine deamination in patients treated with high doses and correlation with response

1 reference

12 December 2020

Isolation and characterization of a deoxycytidine kinase-deficient human promyelocytic leukemic cell line highly resistant to 1-beta-D- arabinofuranosylcytosine

1 reference

12 December 2020

Deoxycytidine kinase and deoxycytidine deaminase activities in human tumour xenografts

1 reference

12 December 2020

Induction of apoptotic cell death in chronic lymphocytic leukemia by 2-chloro-2'-deoxyadenosine and 9-beta-D-arabinosyl-2-fluoroadenine

1 reference

12 December 2020

Mechanisms of resistance of human acute leukaemia cells to cytosine arabinoside.

1 reference

12 December 2020

Deoxyguanosine-resistant leukemia L1210 cells. Loss of specific deoxyribonucleoside kinase activity

1 reference

12 December 2020

Lasting remissions in hairy-cell leukemia induced by a single infusion of 2-chlorodeoxyadenosine

1 reference

12 December 2020

Role of uridine triphosphate in the phosphorylation of 1-beta-D-arabinofuranosylcytosine by Ehrlich ascites tumor cells

1 reference

12 December 2020

Determination of the antimetabolite Gemcitabine (2',2'-difluoro-2'-deoxycytidine) and of 2',2'-difluoro-2'-deoxyuridine by 19F nuclear magnetic resonance spectroscopy

1 reference

12 December 2020

Augmentation of 1-beta-D-arabinofuranosylcytosine cytotoxicity in human tumor cells by inhibiting drug efflux.

1 reference

12 December 2020

High-dose cytosine arabinoside: pharmacological and clinical aspects

1 reference

12 December 2020

Increased deoxycytidine kinase activity in cancer cells and inhibition by difluorodeoxycytidine

1 reference

12 December 2020

Preclinical antitumor activity of 5-aza-2'-deoxycytidine against human and neck cancer xenografts [corrected].

1 reference

12 December 2020

1-Beta-arabinofuranosylcytosine in therapy of leukemia: preclinical and clinical overview

1 reference

12 December 2020

Differences in metabolism and cytotoxicity between 9-beta-D arabinofuranosyladenine and 9-beta-D-arabinofuranosyl-2-fluoroadenine in human leukemic lymphoblasts

1 reference

12 December 2020

Comparison of the cellular pharmacokinetics and toxicity of 2',2'-difluorodeoxycytidine and 1-beta-D-arabinofuranosylcytosine

1 reference

12 December 2020

Activation of the jun-D gene during treatment of human myeloid leukemia cells with 1-beta-D-arabinofuranosylcytosine

1 reference

12 December 2020

Clinical and preclinical activity of 2',2'-difluorodeoxycytidine (gemcitabine).

1 reference

12 December 2020

Quantitative immunoassay of human deoxycytidine kinase in malignant cells

1 reference

12 December 2020

Relationship between leukemic cell retention of cytosine arabinoside triphosphate and the duration of remission in patients with acute non-lymphocytic leukemia.

1 reference

12 December 2020

Fludarabine: a new agent with marked cytoreductive activity in untreated chronic lymphocytic leukemia

1 reference

12 December 2020

Mechanism for ara-CTP catabolism in human leukemic cells and effect of deaminase inhibitors on this process

1 reference

12 December 2020

The locus of action of 1-beta-d-arabinofuranosylcytosine in the cell cycle

1 reference

12 December 2020

Comparison of the substrate specificities of human thymidine kinase 1 and 2 and deoxycytidine kinase toward antiviral and cytostatic nucleoside analogs

1 reference

12 December 2020

Role of deoxycytidine kinase in an in vitro model for AraC- and DAC-resistance: substrate-enzyme interactions with deoxycytidine, 1-beta-D-arabinofuranosylcytosine and 5-aza-2'-deoxycytidine

1 reference

12 December 2020

Deoxynucleoside phosphorylating enzymes in monkey and human tissues show great similarities, while mouse deoxycytidine kinase has a different substrate specificity

1 reference

12 December 2020

Pyrimidine pathways enzymes in human tumors of brain and associated tissues: potentialities for the therapeutic use of N-(phosphonacetyl-L-aspartate and 1-beta-D-arabinofuranosylcytosine

1 reference

12 December 2020

Cytosine arabinoside influx and nucleoside transport sites in acute leukemia

1 reference

12 December 2020

Deoxycytidine kinase is constitutively expressed in human lymphocytes: consequences for compartmentation effects, unscheduled DNA synthesis, and viral replication in resting cells

1 reference

12 December 2020

Determinants of response to antimetabolites and their modulation by normal purine and pyrimidine metabolites

1 reference

12 December 2020

On the mechanism of inhibition of DNA-cytosine methyltransferases by cytosine analogs

1 reference

12 December 2020

Evaluation of the antitumor activity of gemcitabine (2',2'-difluoro-2'-deoxycytidine).

1 reference

12 December 2020

Regulation of purine deoxynucleoside phosphorylation by deoxycytidine kinase from human leukemic blast cells

1 reference

12 December 2020

Human deoxycytidine kinase: kinetic mechanism and end product regulation

1 reference

12 December 2020

In vivo development of cytosine arabinoside resistance in the BN acute myelocytic leukemia.

1 reference

12 December 2020

A simplified assay for measurement of cytosine arabinoside incorporation into DNA in Ara-C-sensitive and -resistant leukemic cells

1 reference

12 December 2020

The purine analogs--a therapeutic beauty contest

1 reference

12 December 2020

Kinetic properties and inhibition of human T lymphoblast deoxycytidine kinase

1 reference

12 December 2020

Transport of nucleoside drugs in animal cells

1 reference

12 December 2020

Cloning and expression of human deoxycytidine kinase cDNA

1 reference

12 December 2020

Kinetic studies on 2',2'-difluorodeoxycytidine (Gemcitabine) with purified human deoxycytidine kinase and cytidine deaminase

1 reference

12 December 2020

Studies on 1-?-D-arabinofuranosyl cytosine-resistant mutants of Chinese hamster fibroblasts: III. Joint resistance to arabinofuranosyl cytosine and to excess thymidine?A semidominant manifestation of deoxycytidine triphosphate pool expansion

1 reference

12 December 2020

Enhancement of anti-neoplastic activity of cytosine arabinoside against human HL-60 myeloid leukemic cells by 3-deazauridine

1 reference

12 December 2020

Fludarabine potentiates metabolism of cytarabine in patients with acute myelogenous leukemia during therapy

1 reference

12 December 2020

Distribution of kinase and deaminase of 1-beta-D-arabinofuranosylcytosine in tissues of man and mouse

1 reference

12 December 2020

Inhibition of fludarabine metabolism by arabinosylcytosine during therapy

1 reference

12 December 2020

Membrane transport and the antineoplastic action of nucleoside analogues

1 reference

12 December 2020

Deoxycytidine protects normal bone marrow progenitors against Ara-C and gemcitabine cytotoxicity without compromising their activity against cisplatin-resistant human ovarian cancer cells

1 reference

12 December 2020

Cellular pharmacodynamics of anticancer drugs

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF01880661

1 reference

22 September 2017

1 reference