(Q34572224)

3 August 2017

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title

Modelling viral and immune system dynamics (English)

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3 August 2017

1

Alan S Perelson

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3 August 2017

1 January 2002

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Nature Reviews Immunology

3 August 2017

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3 August 2017

2

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3 August 2017

1

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3 August 2017

28-36

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Theoretical studies of clonal selection: Minimal antibody repertoire size and reliability of self-non-self discrimination

3 August 2017

1 reference

Cyclic re-entry of germinal center B cells and the efficiency of affinity maturation

31 March 2020

1 reference

How diverse should the immune system be?

31 March 2020

1 reference

Predicting the size of the T-cell receptor and antibody combining region from consideration of efficient self-nonself discrimination

31 March 2020

1 reference

Kinetic proofreading in T-cell receptor signal transduction

31 March 2020

1 reference

Resource competition as a mechanism for B cell homeostasis

31 March 2020

1 reference

Variable efficacy of repeated annual influenza vaccination

31 March 2020

1 reference

Explaining high alloreactivity as a quantitative consequence of affinity-driven thymocyte selection

31 March 2020

1 reference

Competition for antigenic sites during T cell proliferation: a mathematical interpretation of in vitro data

31 March 2020

1 reference

The paradox of alloreactivity and self MHC restriction: quantitative analysis and statistics

31 March 2020

1 reference

Kinetic proofreading models for cell signaling predict ways to escape kinetic proofreading

31 March 2020

1 reference

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

31 March 2020

1 reference

Viral dynamics in human immunodeficiency virus type 1 infection

31 March 2020

1 reference

HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time

31 March 2020

1 reference

HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy

31 March 2020

1 reference

31 March 2020

1 reference

Viral counts count in HIV infection

31 March 2020

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Inappropriate model-fitting methods may lead to significant underestimates of viral decay rates in HIV dynamic studies

31 March 2020

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Rapid production and clearance of HIV-1 and hepatitis C virus assessed by large volume plasma apheresis

31 March 2020

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Virus dynamics and drug therapy

31 March 2020

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Mathematical analysis of antiretroviral therapy aimed at HIV-1 eradication or maintenance of low viral loads

31 March 2020

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Relationships between antiviral treatment effects and biphasic viral decay rates in modeling HIV dynamics

31 March 2020

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Individual prognoses of long-term responses to antiretroviral treatment based on virological, immunological and pharmacological parameters measured during the first week under therapy

31 March 2020

1 reference

Short-term measures of relative efficacy predict longer-term reductions in human immunodeficiency virus type 1 RNA levels following nelfinavir monotherapy

31 March 2020

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Decay characteristics of HIV-1-infected compartments during combination therapy

31 March 2020

1 reference

Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy

31 March 2020

1 reference

Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection

31 March 2020

1 reference

Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy.

31 March 2020

1 reference

Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy

31 March 2020

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Recovery of replication-competent HIV despite prolonged suppression of plasma viremia

31 March 2020

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Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy

31 March 2020

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Persistence of HIV-1 Transcription in Peripheral-Blood Mononuclear Cells in Patients Receiving Potent Antiretroviral Therapy

31 March 2020

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Residual HIV-1 RNA in blood plasma of patients taking suppressive highly active antiretroviral therapy

31 March 2020

1 reference

Persistence of episomal HIV-1 infection intermediates in patients on highly active anti-retroviral therapy

31 March 2020

1 reference

Latency and viral persistence in HIV-1 infection

31 March 2020

1 reference

Dissociation of HIV-1 from follicular dendritic cells during HAART: mathematical analysis

31 March 2020

1 reference

Influence of follicular dendritic cells on decay of HIV during antiretroviral therapy

31 March 2020

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Influence of follicular dendritic cells on HIV dynamics

31 March 2020

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Persistence of infectious HIV on follicular dendritic cells

31 March 2020

1 reference

Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy

31 March 2020

1 reference

Ultrarapid hepatitis C virus clearance by daily high-dose interferon in non-responders to standard therapy

31 March 2020

1 reference

Dynamics of hepatitis C viremia following interferon-alpha administration

31 March 2020

1 reference

Differences in viral dynamics between genotypes 1 and 2 of hepatitis C virus

31 March 2020

1 reference

Viral dynamics in hepatitis B virus infection

31 March 2020

1 reference

Biphasic clearance kinetics of hepatitis B virus from patients during adefovir dipivoxil therapy

31 March 2020

1 reference

Combination therapy with lamivudine and famciclovir for chronic hepatitis B-infected Chinese patients: a viral dynamics study.

31 March 2020

1 reference

Analysis of hepatitis B viral load decline under potent therapy: complex decay profiles observed.

31 March 2020

1 reference

Viral Clearance Without Destruction of Infected Cells During Acute HBV Infection

31 March 2020

1 reference

Kinetics of acute hepatitis B virus infection in humans.

31 March 2020

1 reference

The dynamics of human cytomegalovirus replication in vivo

31 March 2020

1 reference

Prediction of cytomegalovirus load and resistance patterns after antiviral chemotherapy

31 March 2020

1 reference

Reduction of HIV concentration during acute infection: independence from a specific immune response.

31 March 2020

1 reference

Population dynamics of immune responses to persistent viruses.

31 March 2020

1 reference

Modeling plasma virus concentration during primary HIV infection

31 March 2020

1 reference

Assessing CD8 T cell number and dysfunction in the presence of antigen

31 March 2020

1 reference

Simian immunodeficiency virus (SIV) infection of a rhesus macaque induces SIV-specific CD8(+) T cells with a defect in effector function that is reversible on extended interleukin-2 incubation

31 March 2020

1 reference

Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence

31 March 2020

1 reference

Immune function in mice lacking the perforin gene

31 March 2020

1 reference

Recruitment times, proliferation, and apoptosis rates during the CD8(+) T-cell response to lymphocytic choriomeningitis virus

31 March 2020

1 reference

Modelling the dynamics of LCMV infection in mice: conventional and exhaustive CTL responses.

31 March 2020

1 reference

Phenotypic analysis of antigen-specific T lymphocytes

31 March 2020

1 reference

A new theory of cytotoxic T-lymphocyte memory: implications for HIV treatment.

31 March 2020

1 reference

Correlates of cytotoxic T-lymphocyte-mediated virus control: implications for immunosuppressive infections and their treatment

31 March 2020

1 reference

The role of T cell help for anti-viral CTL responses

31 March 2020

1 reference

Prognosis in HIV-1 infection predicted by the quantity of virus in plasma

31 March 2020

1 reference

Small variations in multiple parameters account for wide variations in HIV-1 set-points: a novel modelling approach.

31 March 2020

1 reference

Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes

31 March 2020

1 reference

Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques.

31 March 2020

1 reference

Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells

31 March 2020

1 reference

CD8+ T cells suppress human immunodeficiency virus replication by inhibiting viral transcription

31 March 2020

1 reference

Viral dynamics in vivo: limitations on estimates of intracellular delay and virus decay

31 March 2020

1 reference

Influence of delayed viral production on viral dynamics in HIV-1 infected patients.

31 March 2020

1 reference

Improved estimates for HIV-1 clearance rate and intracellular delay

31 March 2020

1 reference

A model of HIV-1 pathogenesis that includes an intracellular delay.

31 March 2020

1 reference

Effect of drug efficacy and the eclipse phase of the viral life cycle on estimates of HIV viral dynamic parameters

31 March 2020

1 reference

Measurement of cell proliferation by labeling of DNA with stable isotope-labeled glucose: studies in vitro, in animals, and in humans

31 March 2020

1 reference

Measurement of T-cell kinetics: recent methodologic advances

31 March 2020

1 reference

Rapid turnover of T lymphocytes in SIV-infected rhesus macaques.

31 March 2020

1 reference

Increased turnover of T lymphocytes in HIV-1 infection and its reduction by antiretroviral therapy

31 March 2020

1 reference

Factors influencing T-cell turnover in HIV-1-seropositive patients

31 March 2020

1 reference

Quantification of cell turnover kinetics using 5-bromo-2'-deoxyuridine.

31 March 2020

1 reference

Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans

31 March 2020

1 reference

A computer model of cellular interactions in the immune system

31 March 2020

1 reference

Using lazy evaluation to simulate realistic-size repertoires in models of the immune system

31 March 2020

1 reference

Modeling deuterated glucose labeling of T-lymphocytes

31 March 2020

1 reference

Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptase

31 March 2020

1 reference

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7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRI700

1 reference

3 August 2017

1 reference

PubMed ID

11905835